CFD Analysis of Pulsatile Non-Newtonian Blood Flow in a Multi-Staged Stenosed Bifurcated Carotid Artery

Jump To References Section

Authors

  • Department of Mathematics, Ramaiah Institute of Technology, Bangalore – 560054, Karnataka ,IN
  • Department of Physics, Ramaiah Institute of Technology, Bangalore – 560054, Karnataka ,IN
  • Department of Mechanical Engineering, Ramaiah Institute of Technology, Bangalore – 560054, Karnataka ,IN
  • Department of Mechanical Engineering, Ramaiah Institute of Technology, Bangalore – 560054, Karnataka ,IN

DOI:

https://doi.org/10.18311/jmmf/2023/35806

Keywords:

Atherosclerosis, Computational Fluid Dynamics, Non-Newtonian Behaviour

Abstract

Accumulation of plaque on the arterial walls leads to a cardiovascular condition known as Atherosclerosis. This leads to lumen stenosis, and when it occurs in the carotid artery, it can impede the blood-flow to the face, brain, and neck, potentially leading to a stroke. The aim of this paper is to provide a comprehensive study of the carotid artery under multiple stenosed conditions using Computational Fluid Dynamics. In this study, blood has been considered to be a non-Newtonian fluid exhibiting pulsatile flow based upon the Carreau model and a two-dimensional bifurcated human carotid artery has been modelled. The Navier-Stokes equations-based FVM (Finite Volume Method) is used to analyze the flow inside the artery, while RANS k-ω SST turbulence model has been applied in the analysis of parameters of blood under stenosed conditions. Four models based on different stages of stenosis (0%; 25%; 50% and 75%) have been developed with simulations run on Ansys to find the effects under stenosis. For all the simulations, 65:35 flow division has been used, indicating that 65% of the total blood flows through the Internal Carotid Artery and 35% flows through the External Carotid Artery. Velocity and pressure contour, velocity distribution on the modelled plane and wall shear stress on arterial walls are the primary parameters studied at varying timescales of a cardiac cycle. As the stenosis stage increases, the flow separation can be predicted with higher accuracy. With the help of these parameters, one can build and design better treatment choices, such as designing of stents with different materials or adding of Ag-Au (Silver - Gold) nanoparticles in the blood to change the hemodynamics.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Downloads

Published

2023-12-20

How to Cite

Anand, M., Aggarwal, S., Harshit Raj, & Gajjar, D. (2023). CFD Analysis of Pulsatile Non-Newtonian Blood Flow in a Multi-Staged Stenosed Bifurcated Carotid Artery. Journal of Mines, Metals and Fuels, 71(10), 1601–1611. https://doi.org/10.18311/jmmf/2023/35806

 

References

Cheng Tu, Michel Deville. Pulsatile flow of non-Newtonian fluids through arterial stenoses. J. Biomech. 1996 July; 29(7):899-908. https://doi.org/10.1016/0021- 9290(95)00151-4 DOI: https://doi.org/10.1016/0021-9290(95)00151-4

Long Q, Xua XY, Ramnarineb KV, Hoskinsb P. Numerical investigation of physiologically realistic pulsatile flow through arterial stenosis. J Biomech. 2001 Oct.; 34(10):1229-42. https://doi.org/10.1016/S0021- 9290(01)00100-2 DOI: https://doi.org/10.1016/S0021-9290(01)00100-2

Chan WY, Ding Y, Tu JY. Modeling of non-Newtonian blood flow through a stenosed artery incorporating fluid-structure interaction. ANZIAM J. 2005 Nov. 21; 47:C507-23 https://doi.org/10.21914/anziamj.v47i0.1059 DOI: https://doi.org/10.21914/anziamj.v47i0.1059

Sankar DS, AhmadIzaniMd Ismail. Two-Fluid Mathematical Models for Blood Flow in Stenosed Arteries: A Comparative Study. Boundary Value Problems. 2009 Feb. 10; Article number:568657 https:// doi.org/10.1155/2009/568657 DOI: https://doi.org/10.1155/2009/568657

Moreno C, Bhaganagar K. Modeling of Stenotic Coronary Artery and Implications of Plaque Morphology on Blood Flow. Hindawi Publishing Corporation Modelling and Simulation in Engineering. 2013 Nov. 12; Article ID: 390213. https://doi.org/10.1155/2013/390213 DOI: https://doi.org/10.1155/2013/390213

Mahalingam A, Gawandalkar UU, Kini G, Buradi A, Araki T, Ikeda N, Nicolaides A, Laird JR, Saba L, Suri JS. Numerical analysis of the effect of turbulence transition on the hemodynamic parameters in human coronary arteries. Cardiovascular Diagnosis and Therapy. 2016 Jun; 6(3):208-20. https://doi.org/10.21037/cdt.2016.03.08 DOI: https://doi.org/10.21037/cdt.2016.03.08

Eshtehardi P, Brown AJ, Bhargava A, Costopoulos C, Hung OY, Corban MT, Hosseini H, Gogas Bill D, Giddens DP, Samady H. High wall shear stress and high-risk plaque: an emerging concept. Int J Cardiovasc Imaging. 2016 July; 33(7):1089-99. https://doi.org/10.1007/ s10554-016-1055-1 DOI: https://doi.org/10.1007/s10554-016-1055-1

Moradicheghamahi J, Sadeghiseraji J, Jahangiri M. Numerical solution of the Pulsatile, non-Newtonian and turbulent blood flow in a patient specific elastic carotid artery. Int J Mech Sci. 2019 January; 150:393-403. https:// doi.org/10.1016/j.ijmecsci.2018.10.046 DOI: https://doi.org/10.1016/j.ijmecsci.2018.10.046

Nagargoje MS, Mishra DK, Gupta R. Pulsatile flow dynamics in symmetric and asymmetric bifurcating vessels. Physics of Fluids. 2021 July 1; 33(7):071904. https:// doi.org/10.1063/5.0056414 DOI: https://doi.org/10.1063/5.0056414

Carvalho V, Rodrigues N, Lima RA, Teixeira S. Modeling Blood Pulsatile Turbulent Flow in Stenotic Coronary Arteries. Int J Biol Biomed. 2020 Nov.; 14(22):160-8. https://doi.org/10.46300/91011.2020.14.22 DOI: https://doi.org/10.46300/91011.2020.14.22

Perktold K, Resch M, Peter RO. Three-Dimensional Numerical Analysis of Pulsatile Flow and Wall Shear Stress in the Carotid Artery Bifurcation. J. Biomechanics. 1991; 24(6):409-20. https://doi. org/10.1016/0021-9290(91)90029-m DOI: https://doi.org/10.1016/0021-9290(91)90029-M

Husain I, Labropulu F, Langdon C, Schwark J. A comparison of Newtonian and non-Newtonian models for pulsatile blood flow simulations. J Mech Behav Mater. 2013; 21(5-6):147-53. https://doi.org/10.1515/jmbm- 2013-0001 DOI: https://doi.org/10.1515/jmbm-2013-0001

Sinnott M, Cleary PW, Prakash M. An investigation of pulsatile blood flow in a bifurcation artery using a gridfree method. Fifth International Conference on CFD in the Process Industries (Australia). 2006 Dece; pp. 13-5.

Filardi V. Carotid Artery Stenosis near a Bifurcation Investigated by Fluid Dynamic Analyses. Neuroradiol J. 2013 Aug. 27; 26(4):439-53. https://doi. org/10.1177/197140091302600409 DOI: https://doi.org/10.1177/197140091302600409

Tripathi J, Vasu B, Anwar Bég O. Computational simulations of hybrid mediated nano-hemodynamics (Ag-Au/Blood) through an irregular symmetric stenosis. Comp Biol Med. 2021 Mar.; 130:104213. https://doi. org/10.1016/j.compbiomed.2021.104213 DOI: https://doi.org/10.1016/j.compbiomed.2021.104213