Cardioprotective Effect of Banaba on Myocardial Ischemia/Reperfusion Injury in Rats

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Authors

  • Vipin Dhote
     VNS Faculty of Pharmacy, Bhopal – 462044, Madhya Pradesh ,IN
  • Ramachandran Balaraman
     Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara – 391760, Gujarat ,IN
  • Muthu K. Mohan Maruga Raja
     Parul Institute of Pharmacy & Research, Parul University, Vadodara – 391760, Gujarat ,IN

DOI:

https://doi.org/10.18311/jnr/2020/25156

Keywords:

Antioxidant, Anti-inflammatory and Anti-apoptotic, Lagerstroemia speciosa L.

Abstract

The ethanol extract of Banaba (Lagerstroemia speciosa L.) leaves, was investigated for their effects on ischemia/reperfusion (I/R) injury induced by occlusion of the left descending coronary artery (LCA) for 1 h, followed by re-opening again for 1 h. Banaba ethanol extract (100 mg/kg) intraperitonially (i.p.) was administered 30 min after induction of ischemia. During I/R period, the hemodynamics and ECG parameters were measured. Oxidative stress markers like reduced glutathione (GSH), Superoxide dismutase (SOD), malondialdehyde (MDA), activities of myeloperoxidase (MPO), creatine kinase (CK) and myocardial infarct area were significantly (P<0.05) reduced in Wistar rats after Banaba treatment. The apoptotic activity and histological observations were influenced by Banaba. The cardioprotective effect of Banaba could be attributed to its ability to improve the antioxidant mechanism, anti-inflammatory and anti-apoptotic activity in ischemic animals.

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Published

2020-10-01

How to Cite

Dhote, V., Balaraman, R., & Mohan Maruga Raja, M. K. (2020). Cardioprotective Effect of <i>Banaba</i> on Myocardial Ischemia/Reperfusion Injury in Rats. Journal of Natural Remedies, 20(3), 140–148. https://doi.org/10.18311/jnr/2020/25156

Issue

Volume 20, Issue 3, July 2020

Section

Research Articles
Crossref
Scopus
Google Scholar
Europe PMC
Received 2020-04-11
Accepted 2020-05-18
Published 2020-10-01

 

References

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