Alpha-amylase and Alpha-glucosidase Inhibitory Activities of Philippine Indigenous Medicinal Plants

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Authors

  • Edgardo E. Tulin
     Tuklas Lunas Development Centre, Visayas State University, Baybay City, Visca, Leyte – 6521 ,PH
  • Jo Jane D. Atok
     Tuklas Lunas Development Centre, Visayas State University, Baybay City, Visca, Leyte – 6521 ,PH
  • Anabella B. Tulin
     Advanced Research and Innovation Centre, Visayas State University, Visca, Baybay City, Leyte – 6521 ,PH
  • April Joy S. Vergara
     Tuklas Lunas Development Centre, Visayas State University, Baybay City, Visca, Leyte – 6521 ,PH
  • Ma. Theresa P. Loreto
     Advanced Research and Innovation Centre, Visayas State University, Visca, Baybay City, Leyte – 6521 ,PH

DOI:

https://doi.org/10.18311/jnr/2024/29845

Keywords:

Alpha-amylase, Alpha-glucosidase, Diabetes, Medicinal Plants

Abstract

In the Philippines, medicinal plants still provide the first line of therapeutic remedies and their reported efficacy in traditional treatments provides an opportunity for drug discovery and development. The study aimed to evaluate in vitro commonly used Philippine medicinal plants for their alpha-amylase and alpha-glucosidase inhibitory activities as potential sources of antidiabetic agents. The study emphasised the inhibitory activities of 54 medicinal plants against α-amylase and α-glucosidase enzymes. The findings revealed 7 medicinal plants with the highest alpha-glucosidase inhibitory activity of ≥ 50% and 3 with alpha-amylase inhibitory activity of ≥ 20%. Ethyl acetate extract of Cycas sp. exhibited the highest α-glucosidase inhibitory activity with 83.87% ± 1.52 followed by the aqueous extract of cf. Calyptranthera sp. With 82.07% ± 0.14 with Acarbose as the reference standard (99.71% ± 0.63) at 10µg/mL (w/v) concentration. For the alpha-amylase inhibitory assay, the highest bioactivity was observed in ethyl acetate extract of Curcuma longa L. (39.44% ± 1.56) with Acarbose as the reference standard (51.59% ± 0.98) at 10µg/mL (w/v) concentration. These findings suggest the potential of the above-mentioned plants as sources of alpha-amylase and alpha-glucosidase inhibitors that may be used as antidiabetic agents.

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Published

2024-04-01

How to Cite

Tulin, E. E., Atok, J. J. D., Tulin, A. B., Vergara, A. J. S., & Loreto, M. T. P. (2024). Alpha-amylase and Alpha-glucosidase Inhibitory Activities of Philippine Indigenous Medicinal Plants. Journal of Natural Remedies, 24(4), 877–884. https://doi.org/10.18311/jnr/2024/29845

Issue

Volume 24, Issue 4, April 2024

Section

Short Communication

License

Copyright (c) 2024 Edgardo Escuadra Tulin, Jo Jane D. Atok, Anabella B. Tulin, April Joy S. Vergara, Ma. Theresa P. Loreto

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

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Europe PMC
Received 2022-03-25
Accepted 2023-09-19
Published 2024-04-01

 

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