An Updated Review on Medicinal Plants with Hepato-protective Activity

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Authors

  • Yash Janve
     Department of Pharmacology, Parul Institute of Pharmacy and Research, Parul University, Vadodara - 391110, Gujarat ,IN
  • Jagdish Kakadiya
     Department of Pharmacology, Parul Institute of Pharmacy and Research, Parul University, Vadodara - 391110, Gujarat ,IN
  • Mohan Raja
     Department of Pharmacology, Parul Institute of Pharmacy and Research, Parul University, Vadodara - 391110, Gujarat ,IN

DOI:

https://doi.org/10.18311/jnr/2023/30924

Keywords:

ALP, ALT, Anti-oxidant, AST, Liver Disease.

Abstract

Many precious medicines from traditional medicinal plants can be produced using a phototherapeutic approach to modern drug research. Finding pure phytochemicals that can be used as medicines requires time and money. The treatment of liver problems involves the use of numerous herbs and polyherbal mixtures. However, the treatments are ineffective in the majority of severe instances. Even though many of these plants and mixtures were subjected to experimental evaluations, the research was frequently insufficient and uncompleted. It was found that the therapeutic effects were evaluated in animals with subclinical liver damage brought on by a few substances. Antioxidants included in common foods can offer this kind of defence against liver damage brought on by hazardous substances’ oxidative processes. Therefore, hepato-protective natural products such as Phyllanthus amarus, Silybum marianum, Solanum nigrum, Tephrosia purpurea, Eclipta alba, Cichorium intybus, Phyllanthus Niruri, Centella asiatica, Capparis spinosa, Terminalia arjuna, Cassia occidentalis, Fumaria parviflora, Embelia ribes, Boerhaavia diffusa, Tamarix gallica, Achillea millefolium, Terminalia chebula, Ocimum sanctum, Glycyrrhiza glabra, Foeniculum vulgare, Garcinia mangostana, Acacia Catechu, Pergularia daemia, Annona squamosa, Flacourtia indica. The goal of the current review is to gather information on promising phytochemicals from medicinal plants that have been evaluated in hepatotoxicity models utilising cutting-edge scientific methods.

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Published

2023-03-23

How to Cite

Janve, Y., Kakadiya, J., & Raja, M. (2023). An Updated Review on Medicinal Plants with Hepato-protective Activity. Journal of Natural Remedies, 23(1), 47–55. https://doi.org/10.18311/jnr/2023/30924

Issue

Volume 23, Issue 1, January 2023

Section

Short Review

License

Copyright (c) 2023 Jagdish Labhubhai Kakadiya, Yash Subhash Janve, Mohan maruga raja

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

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Europe PMC
Received 2022-08-10
Accepted 2023-03-23
Published 2023-03-23

 

References

Hari Kumar C, Ramesh A, Suresh Kumar J, Mohammed Ishaq B. A Review on Hepato-protective Activity of Medicinal Plants. International Journal of Pharmaceutical Sciences and Research. 2011; 2(3):501-515.

Mohamed Saleem T, Madhusudhana Chetty C, Ramkanth S, Rajan V, Mahesh Kumar K, Gauthaman K. Hepato-protective Herbs – A Review. International Journal of Research in Pharmaceutical Sciences. 2010; 1(1):1-5.

Mohan Maruga Raja MK, Patel RS, Mishra SH. Identification and quantification of adrenaline from the leaves of Clerodendrum phlomidis using thin-layer chromatography. Zhong Xi Yi Jie He Xue Bao. 2011; 9(1):105-8. PMID: 21227041. https://doi. org/10.3736/jcim20110117 DOI: https://doi.org/10.3736/jcim20110117

Devarajan A, Mohan Maruga Raja MK. Cytotoxic, Antimitotic, and Antiproliferation Studies on Rasam: A South Indian Traditional Functional Food. Pharmacognosy Mag. 2017; 13(Suppl 3):S452-S457. Epub. PMID: 29142398; PMCID: PMC5669081. https://doi.org/10.4103/pm.pm_138_17 DOI: https://doi.org/10.4103/pm.pm_138_17

Latief U, Ahmad R. Herbal remedies for liver fibrosis: A review on the mode of action of fifty herbs. Journal of Traditional and Complementary Medicine. 2018; 8(3):352-360. https://doi.org/10.1016/j. jtcme.2017.07.002 DOI: https://doi.org/10.1016/j.jtcme.2017.07.002

Shah N, Mitra A. Gastrointestinal and Hepatic Sarcoidosis: A Review Article. Clinical Liver Disease. 2021; 17(4):301-307. https://doi.org/10.1002/cld.1055 DOI: https://doi.org/10.1002/cld.1055

Jagdish Kakadiya, Liver function test - A review. Pharmacology online. 2009; 2:271-282. https://doi. org/10.5005/jp/books/10560_20 DOI: https://doi.org/10.5005/jp/books/10560_20

Paolella G, Farallo M, Degrassi I, Nuti F, Nebbia G. Extra-hepatic autoimmune diseases in autoimmune hepatitis. Digestive and Liver Disease. 2016; 48:e255. https://doi.org/10.1016/j.dld.2016.08.039 DOI: https://doi.org/10.1016/j.dld.2016.08.039

Ogunmoyole T, Awodooju M, Idowu S, Daramola O. Phyllanthus amarus extract restored deranged biochemical parameters in a rat model of hepatotoxicity and nephrotoxicity. Heliyon. 2020; 6(12):e05670. https://doi.org/10.1016/j.heliyon.2020.e05670 DOI: https://doi.org/10.1016/j.heliyon.2020.e05670

Krithika R, Jyothilakshmi V, Prashantha K, Verma R. Mechanism of protective effect of phyllanthin against carbon tetrachloride-induced hepatotoxicity and experimental liver fibrosis in mice. Toxicology Mechanisms and Methods. 2015; 25(9):708-717. https://doi.org/10.3109/15376516.2015.1077361 DOI: https://doi.org/10.3109/15376516.2015.1077361

Gillessen A, Schmidt H. Silymarin as Supportive Treatment in Liver Diseases: A Narrative Review. Advances in Therapy. 2020; 37(4):1279-1301. https:// doi.org/10.1007/s12325-020-01251-y DOI: https://doi.org/10.1007/s12325-020-01251-y

Federico A, Dallio M, Loguercio C. Silymarin/Silybin and Chronic Liver Disease: A Marriage of Many Years. Molecules. 2017; 22(2):191. https://doi.org/10.3390/ molecules22020191 DOI: https://doi.org/10.3390/molecules22020191

Krithika R, Verma R. Solanum nigrum confers protection against CCl4-induced experimental hepatotoxicity by increasing hepatic protein synthesis and regulation of energy metabolism. Clinical Phytoscience. 2019; 5(1):1-8. https://doi.org/10.1186/ s40816-018-0096-5 DOI: https://doi.org/10.1186/s40816-018-0096-5

Tai C, Choong C, Shi Y, Lin Y, Wang C, Lee B, et al. Solanum nigrum Protects against Hepatic Fibrosis via Suppression of Hyperglycemia in High-Fat/Ethanol Diet-Induced Rats. Molecules. 2016; 21(3):269. https://doi.org/10.3390/molecules21030269 DOI: https://doi.org/10.3390/molecules21030269

Gora R, Baxla S, Kerketta P, Patnaik S, Roy B. Hepato-protective activity of Tephrosia purpurea against arsenic-induced toxicity in rats. Indian Journal of Pharmacology. 2014; 46(2):197. https://doi. org/10.4103/0253-7613.129317 DOI: https://doi.org/10.4103/0253-7613.129317

Naik K, Gurushanthaiah M, kavimani M, Prabhu K, Lokanadham S. Hepato-protective Role of Eclipta alba against High Fatty Diet Treated Experimental Models – A Histopathological Study. Maedica A Journal of Clinical Medicine. 2018; 13(3):217-222.

Li G, Gao H, Jian H, Gu J, Wang J. Hepato-protective effect of Cichorium intybus L., a traditional Uighur medicine, against carbon tetrachloride-induced hepatic fibrosis in rats. World Journal of Gastroenterology. 2014; 20(16):4753-4760. https:// doi.org/10.3748/wjg.v20.i16.4753 DOI: https://doi.org/10.3748/wjg.v20.i16.4753

Ezzat M, Okba M, Ahmed S, El-Banna H, Prince A, Mohamed S, et al. In-depth hepato-protective mechanistic study of Phyllanthus niruri: In vitro and in vivo studies and its chemical characterization. Plos One. 2020; 15(1):e0226185. https://doi.org/10.1371/journal.pone.0226185 DOI: https://doi.org/10.1371/journal.pone.0226185

Choi M, Zheng H, Kim J, Lee K, Park Y, Lee D. Protective effects of Centella asiatica leaf extract on dimethylnitrosamine-induced liver injury in rats. Molecular Medicine Reports. 2016; 14(5):4521-4528. https://doi.org/10.3892/mmr.2016.5809 DOI: https://doi.org/10.3892/mmr.2016.5809

Akbari R, Yaghooti H, Jalali M, Khorsandi L, Mohammadtaghvaei N. Capparis spinosa improves the high fat diet-induced non-alcoholic steatohepatitis in rats: the possible role of FGF21. BMC Research Notes. 2020; 13(1):356. https://doi.org/10.1186/s13104-020-05200-4 DOI: https://doi.org/10.1186/s13104-020-05200-4

Meena R, Singh T. Terminalia arjuna bark extract protects against early alcohol-induced liver injury in the rat. BMJ Journal. 2019; 68:59. https://doi. org/10.1136/gutjnl-2019-IDDFAbstracts.109 DOI: https://doi.org/10.1136/gutjnl-2019-IDDFAbstracts.109

Azubuike N, Chinonyelum N, Onyemelukwe A, Obianuju A, Maduakor U. Hepato-protective effects of the leaf extracts of Cassia occidentalis against carbon tetrachloride-induced hepatotoxicity in albino rats. Pharmacolgy Online. 2018; 3:68-74.

Kooshki F, Niazkar H, Shirazi S, Asghari Azar V, Karimi A. Fumaria parviflora improves liver damage and lipid profile changes in STZ-induced diabetic rats. Physiology and Pharmacology. 2020; 24(3):221- 229. https://doi.org/10.32598/ppj.24.3.80 DOI: https://doi.org/10.32598/ppj.24.3.80

Wang H, Zhang H, Wang Y, Yang L, Wang D. Embelin can protect mice from thioacetamide-induced acute liver injury. Biomedicine and Pharmacotherapy. 2019; 118:109360. https://doi.org/10.1016/j.biopha.2019.109360 DOI: https://doi.org/10.1016/j.biopha.2019.109360

Santhosha D, Manasa R, Vishwanath S, Naik S, Mahesh M. Hepato-protective activity of Boerhaavia diffusa L. IP Journal of Nutrition, Metabolism and Health Science. 2020; 3(4):109-113. https://doi. org/10.18231/j.ijnmhs.2020.022 DOI: https://doi.org/10.18231/j.ijnmhs.2020.022

Riaz U, Sadiq N, Tahir M, et al. Hepato-protective effect of Tamarix dioica Roots on Acetaminophen Induced Hepatotoxicity in Male Mice. Journal of Islamic International Medical College. 2018; 13(4):189-193.

Urfi M, Mujahid M, Rahman M, Rahman M. The Role of Tamarix gallica Leaves Extract in Liver Injury Induced by Rifampicin Plus Isoniazid in Sprague Dawley Rats. Journal of Dietary Supplements. 2017; 15(1):24-33. https://doi.org/10.1080/19390211.2017. 1310783 DOI: https://doi.org/10.1080/19390211.2017.1310783

Rezaei S, Ashkar F, Koohpeyma F, Mahmoodi M, Gholamalizadeh M, Mazloom Z, et al. Hydroalcoholic extract of Achillea millefolium improved blood glucose, liver enzymes and lipid profile compared to metformin in streptozotocin-induced diabetic rats. Lipids in Health and Disease. 2020; 19(81):1-7. https://doi.org/10.1186/s12944- 020-01228-4 DOI: https://doi.org/10.1186/s12944-020-01228-4

Choi M, Kim H, Han J, Lee J, Lee J, Chung S, et al. Hepato-protective Effect of Terminalia chebula-againstt-BHP-Induced Acute Liver Injury in C57/ BL6 Mice. Hindawi Publishing Corporation. 2015; 2015:1-11. https://doi.org/10.1155/2015/517350 DOI: https://doi.org/10.1155/2015/517350

Jain A. To evaluate Hepato-protective activity of Leaves of Ocimum sanctum using animal model. Asian Journal of Pharmaceutical and Clinical Research. 2015; 8(4):255-258.

Lahon K, Das S. Hepato-protective activity of Ocimum sanctum alcoholic leaf extract against paracetamol-induced liver damage in Albino rats. Pharmacognosy Research. 2011; 3(1):13. https://doi. org/10.4103/0974-8490.79110 DOI: https://doi.org/10.4103/0974-8490.79110

Li X, Sun R, Liu R. Natural products in licorice for the therapy of liver diseases: Progress and future opportunities. Pharmacological Research. 2019; 144:210-226. https://doi.org/10.1016/j.phrs.2019.04.025 DOI: https://doi.org/10.1016/j.phrs.2019.04.025

Rather M, Dar B, Sofi S, Bhat B, Qurishi M. Foeniculum vulgare: A comprehensive review of its traditional use, phytochemistry, pharmacology, and safety. Arabian Journal of Chemistry. 2016; 9(2):S1574-S1583. https://doi.org/10.1016/j.arabjc.2012.04.011 DOI: https://doi.org/10.1016/j.arabjc.2012.04.011

Ozbek H, Ugras S, Dulger H, Bayram I, Tuncer I, Ozturk G, et al. Hepato-protective effect of Foeniculum vulgare essential oil. Fitoterapia. 2003; 74(3):317-319. https://doi.org/10.1016/S0367-326X(03)00028-5 DOI: https://doi.org/10.1016/S0367-326X(03)00028-5

Abood W, Bradosty S, Shaikh F, Salehen N, Farghadani R, Agha N, et al. Garcinia mangostana peel extracts exhibit hepato-protective activity against thioacetamide-induced liver cirrhosis in rats. Journal of Functional Foods. 2020; 74:104200. https://doi. org/10.1016/j.jff.2020.104200 DOI: https://doi.org/10.1016/j.jff.2020.104200

Lakshmi T, Renukadevi B, Senthilkumar S, Haribalan P, Parameshwari R, Vijayaraghavan R, et al. Seed and bark extracts of Acacia catechu protects liver from acetaminophen induced hepatotoxicity by modulating oxidative stress, antioxidant enzymes and liver function enzymes in Wistar rat model. Biomedicine and Pharmacotherapy. 2018; 108:834-844. https:// doi.org/10.1016/j.biopha.2018.08.077 DOI: https://doi.org/10.1016/j.biopha.2018.08.077

Bhadauria M, Mishra G, Chandra H, Sahu N, Nirala S. Ameliorative effect of Pergularia daemia (Forssk.) Chiov. leaves extract against anti-tuberculosis drugs induced liver injury in rats. Asian Pacific Journal of Tropical Medicine. 2018; 11(9):518. https://doi. org/10.4103/1995-7645.242310 DOI: https://doi.org/10.4103/1995-7645.242310

Zahid M, Arif M, Rahman M, Mujahid M. Hepato-protective and antioxidant activities of Annona squamosa seed extract against alcohol-induced liver injury in Sprague Dawley rats. Drug and Chemical Toxicology. 2018; 43(6):588-594. https://doi.org/10.1 080/01480545.2018.1517772 DOI: https://doi.org/10.1080/01480545.2018.1517772

M Basuny A. Hepatocurative and Gluco-stabilizing Potentials of Ethanol Extract of Stem bark of Flacourtia indica in Aluminium Chloride induced Toxicity in Albino Wistar rats. Current Trends in Biomedical Engineering and Biosciences. 2019; 18(1):72-78. https://doi.org/10.19080/CTBEB.2019.18.555976 DOI: https://doi.org/10.19080/CTBEB.2019.18.555976