Phytosomes: A Contemporary Method for Delivering Novel Herbal Drugs
DOI:
https://doi.org/10.18311/jnr/2024/34470Keywords:
Herbal, Novel Drug Delivery, Phytosome, Phospholipid, Phyto-phospholipid ComplexlipidAbstract
Our country has a wealth of Ayurvedic expertise, but only recently has its full potential been recognized. Any herbal medication’s efficacy depends on the medically active substance being delivered at an effective dosage. When given directly or externally, their bioavailability is severely constrained. With increased effectiveness, quality, and enhancement of active plant components, phytosome technology has evolved as a dedicated and hopeful means of delivering new drugs. Traditional herbal remedies have been used for a long time to successfully treat various types of illnesses, but their effectiveness has often been limited by the difficulty of getting the active compounds to their intended targets in the body. However, recent advances in herbal formulation technology have made it possible to create more efficient and targeted delivery systems for these compounds. This study emphasizes the special qualities of the phyto-phospholipid complex and how they are used in cutting-edge natural drug administration. The emphasis of the current review is on phytosome production and characterization methods, benefits, and significant developments.
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Copyright (c) 2024 Divya Kanojiya, Ghanshyam Parmar, Bhavik Chauhan, Shamana Gondalia, Monika Rakholiya (Author)
This work is licensed under a Creative Commons Attribution 4.0 International License.
Accepted 2023-11-29
Published 2024-02-01
References
Bombardelli E, Curri SB, Della Loggia R, Del Negro P, Tubaro A, Gariboldi P. Complexes between phospholipids and vegetal derivatives of biological interest. Fitoterapia.1989; 60:1-9.
Manach C, Scalbert A, Morand C, Rémésy C, Jiménez L. Polyphenols: food sources and bioavailability. Am J Clin Nutr. 2004; 79(5):727-47. https://doi.org/10.1093/ajcn/79.5.727 DOI: https://doi.org/10.1093/ajcn/79.5.727
Moscarella S, Giusti A, Marra F, Marena C, Lampertico M, Relli P, et al. Therapeutic and antilipoperoxidant effects of the silybin-phosphatidylcholine complex in chronic liver disease: Preliminary results. Computed Tomography Ratio. 1993; 53(1):98-102. https://doi.org/10.1016/S0011- 393X(05)80160-2 DOI: https://doi.org/10.1016/S0011-393X(05)80160-2
Lu M, Qiu Q, Luo X, Liu X, Sun J, Wang C, et al. Phytophospholipid complexes (phytosomes): A novel strategy to improve the bioavailability of active constituents. Asian J Pharm Sci. 2019; 14(3):265-74. https://doi.org/10.1016/j. ajps.2018.05.011 DOI: https://doi.org/10.1016/j.ajps.2018.05.011
Fernández-García R, Lalatsa A, Statts L, Bolás-Fernández F, Ballesteros MP, Serrano DR. Transferosomes as nanocarriers for drugs across the skin: Quality by design from lab to industrial scale. Int J Pharm. 2020; 573:118817. https://doi.org/10.1016/j.ijpharm.2019.118817 DOI: https://doi.org/10.1016/j.ijpharm.2019.118817
Karimi N, Ghanbarzadeh B, Hamishehkar H, Keyvani F, Pezeshki A, Gholian MM. Phytosome and liposome: the beneficial encapsulation systems in drug delivery and food application. 2015; 2(3):17-27. https://doi.org/10.22037/afb. v2i3.8832
Alharbi WS, Almughem FA, Almehmady AM, Jarallah SJ, Alsharif WK, Alzahrani NM, et al. Phytosomes as an emerging nanotechnology platform for the topical delivery of bioactive phytochemicals. Pharmaceutics. 2021; 13(9):1475. https://doi.org/10.3390/ pharmaceutics13091475 DOI: https://doi.org/10.3390/pharmaceutics13091475
Bozzuto G, Molinari A. Liposomes as nanomedical devices. Int J Nanomed. 2015; 10:975. https://doi.org/10.2147/IJN. S68861 DOI: https://doi.org/10.2147/IJN.S68861
Olga Popovska JS, Kavrakovski Z, Rafajlovska V. An overview: Methods for preparation and characterization of liposomes as drug delivery systems. Int J Pharm Phytopharmacol. 2013; 3(2):13-20.
Karole S, Gupta GK. Preparation and evaluation of phytosomes containing ethanolic extract of leaves of Bombax ceiba for hepatoprotective activity. Evaluation. 2019; 6(2):1-5.
Asghar A, Randhawa MA, Masood MM, Abdullah M, Irshad MA. Nutraceutical formulation strategies to enhance the bioavailability and efficiency: An overview. Role of Materials Science in Food Bioengineering. 2018. p. 329-52. https://doi.org/10.1016/B978-0-12-811448-3.00010-3 DOI: https://doi.org/10.1016/B978-0-12-811448-3.00010-3
Mouhid L, Corzo-Martínez M, Torres C, Vázquez L, Reglero G, Fornari T, et al. Improving in vivo efficacy of bioactive molecules: An overview of potentially antitumor phytochemicals and currently available lipidbased delivery systems. J Oncol. 2017. p. 2017. https://doi. org/10.1155/2017/7351976 DOI: https://doi.org/10.1155/2017/7351976
Bhattacharya S. Phytosomes: the new technology for enhancement of bioavailability of botanicals and nutraceuticals. Int J Health Sci Res. 2009; 2(3):225-32. https://doi.org/10.4314/ijhr.v2i3.47905 DOI: https://doi.org/10.4314/ijhr.v2i3.47905
Ghanbarzadeh B, Babazadeh A, Hamishehkar H. Nanophytosome as a potential food-grade delivery system. Food Biosci. 2016; 15:126-35. https://doi.org/10.1016/j. fbio.2016.07.006
Kidd PM. Bioavailability and activity of phytosome complexes from botanical polyphenols: the silymarin, curcumin, green tea, and grape seed extracts. Altern Med Rev. 2009; 14(3):226-46.
Khan J, Alexander A, Saraf S, Saraf S. Recent advances and future prospects of phyto-phospholipid complexation technique for improving pharmacokinetic profile of plant actives. J Control Release. 2013; 168(1):50-60. https://doi. org/10.1016/j.jconrel.2013.02.025 DOI: https://doi.org/10.1016/j.jconrel.2013.02.025
Shakeri A, Sahebkar A. Opinion paper: phytosome: a fatty solution for efficient formulation of phytopharmaceuticals. Recent Patents on Drug Delivery and Formulation. 2016; 10(1):7-10. https://doi.org/10.2174/1872211309666150813 152305 DOI: https://doi.org/10.2174/1872211309666150813152305
Yanyu X, Yunmei S, Zhipeng C, Qineng P. The preparation of silybin–phospholipid complex and the study on its pharmacokinetics in rats. Int J Pharm. 2006; 307(1):77-82. https://doi.org/10.1016/j.ijpharm.2005.10.001 DOI: https://doi.org/10.1016/j.ijpharm.2005.10.001
Patel J, Patel R, Khambholja K, Patel N. An overview of phytosomes as an advanced herbal drug delivery system. Asian J Pharm Sci. 2009; 4(6):363-71.
Semalty A. Cyclodextrin and phospholipid complexation in solubility and dissolution enhancement: a critical and metaanalysis. Expert Opinion on Drug Delivery. 2014; 11(8):1255- 72. https://doi.org/10.1517/17425247.2014.916271
Tripathy S, Patel DK, Barob L, Naira SK. A review on phytosomes, their characterization, advancement, and potential for transdermal application. J Drug Deliv Ther. 2013; 3(3):147-52. https://doi.org/10.22270/jddt.v3i3.508
Chauhan NS, Gowtham R, Gopalkrishna B. Phytosomes: potential phyto-phospholipid carriers for herbal drug delivery. J Pharm Res. 2009; 2(7):1267-70.
Zhang K, Zhang M, Liu Z, Zhang Y, Gu L, Hu G, et al. Development of quercetin-phospholipid complex to improve the bioavailability and protection effects against carbon tetrachloride-induced hepatotoxicity in SD rats. Fitoterapia. 2016; 113:102-9. https://doi.org/10.1016/j. fitote.2016.07.008 DOI: https://doi.org/10.1016/j.fitote.2016.07.008
Maryana W, Rachmawati H, Mudhakir D. Formation of phytosome containing silymarin using thin layer-hydration technique aimed for oral delivery. Materials Today: Proceedings. 2016; 3(3):855-66. https://doi.org/10.1016/j. matpr.2016.02.019 DOI: https://doi.org/10.1016/j.matpr.2016.02.019
Yue PF, Yuan HL, Li XY, Yang M, Zhu WF. Process optimization, characterization, and evaluation in vivo of oxymatrine–phospholipid complex. Int J Pharm. 2010; 387(1- 2):139-46. https://doi.org/10.1016/j.ijpharm.2009.12.008 DOI: https://doi.org/10.1016/j.ijpharm.2009.12.008
Basnet P, Skalko-Basnet N. Curcumin: an anti-inflammatory molecule from a curry spice on the path to cancer treatment. Molecules. 2011; 16(6):4567-98. https://doi.org/10.3390/ molecules16064567 DOI: https://doi.org/10.3390/molecules16064567
Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature. 1994; 372(6505):425-32. https://doi.org/10.1038/372425a0
Gabetta B, Fuzzati N, Griffini A, Lolla E, Pace R, Ruffilli T, et al. Characterization of proanthocyanidins from grape seeds. Fitoterapia. 2000; 71(2):162-75. https://doi.org/10.1016/ S0367-326X(99)00161-6 DOI: https://doi.org/10.1016/S0367-326X(99)00161-6
El Maghraby GM, Barry BW, Williams A. Liposomes and skin: from drug delivery to model membranes. Eur J Pharm Sci. 2008; 34(4-5):203-22. https://doi.org/10.1016/j. ejps.2008.05.002 DOI: https://doi.org/10.1016/j.ejps.2008.05.002
Chaudhari P, Sharma P, Barhate N, Kulkarni P, Mistry C. Solubility enhancement of hydrophobic drugs using synergistically interacting cyclodextrins and cosolvent. Current Science. 2007; p. 1586-91.
Popa LA. Search for dark higgs inflation with curvature corrections at LHC Experiments. Universe. 2022; 8(4):235. https://doi.org/10.3390/universe8040235 DOI: https://doi.org/10.3390/universe8040235
Nimbalkar CK, Hatware K. Phytosomes-novel drug delivery system. Indian J Drugs. 2017; 5(1):16-36.
Conti M, Malandrino S, Magistretti MJ. Protective activity of silipide on liver damage in rodents. Jpn J Pharmacol. 1992; 60(4):315-21. https://doi.org/10.1254/jjp.60.315 DOI: https://doi.org/10.1254/jjp.60.315
Tripathy S, Patel DK, Barob L, Naira SK. A review of phytosomes, their characterization, advancement, and potential for transdermal application. J Drug Deliv Ther. 2013; 3(3):147-52. https://doi.org/10.22270/jddt.v3i3.508 DOI: https://doi.org/10.22270/jddt.v3i3.508
Amit PY, Tanwar YS, Rakesh S, Poojan P. Phytosome: Phytolipid drug delivery system for improving the bioavailability of the herbal drug. J Pharm Sci Biosci Res. 2013; 3(2):51-7.
Valenzuela A, Aspillaga M, Vial S, Guerra R. Selectivity of silymarin on the increase of the glutathione content in different tissues of the rat. Planta Medica. 1989; 55(05):420- 2. https://doi.org/10.1055/s-2006-962056 DOI: https://doi.org/10.1055/s-2006-962056
Saraf S, Kaur CD. Phytoconstituents as photoprotective novel cosmetic formulations. Phcog Rev. 2010; 4(7):1. https://doi.org/10.4103/0973-7847.65319 DOI: https://doi.org/10.4103/0973-7847.65319
Zhang Z, Chen Y, Deng J, Jia X, Zhou J, Lv H. Solid dispersion of berberine–phospholipid complex/TPGS 1000/ SiO2: preparation, characterization and in vivo studies. Int J Pharm. 2014; 465(1-2):306-16. https://doi.org/10.1016/j. ijpharm.2014.01.023
Habbu P, Madagundi S, Kulkarni R, Jadav S, Vanakudri R, Kulkarni V. Preparation and evaluation of Bacopa– phospholipid complex for antiamnesic activity in rodents. Drug Invent. 2013; 5(1):13-21. https://doi.org/10.1016/j. dit.2013.02.004 DOI: https://doi.org/10.1016/j.dit.2013.02.004
Zhang Z, Chen Y, Deng J, Jia X, Zhou J, Lv H. Solid dispersion of berberine–phospholipid complex/TPGS 1000/ SiO2: preparation, characterization and in vivo studies. Int J Pharm. 2014; 465(1-2):306-16. https://doi.org/10.1016/j. ijpharm.2014.01.023 DOI: https://doi.org/10.1016/j.ijpharm.2014.01.023
Mazumder A, Dwivedi A, Du Preez JL, Du Plessis J. In vitro wound healing and cytotoxic effects of sinigrin–phytosome complex. Int J Pharm. 2016; 498(1-2):283-93. https://doi. org/10.1016/j.ijpharm.2015.12.027
Tedesco D, Steidler S, Galletti S, Tameni M, Sonzogni O, Ravarotto L. Efficacy of the silymarin-phospholipid complex in reducing the toxicity of aflatoxin B1 in broiler chicks. Poult Sci. 2004; 83(11):1839-43. https://doi.org/10.1093/ ps/83.11.1839 DOI: https://doi.org/10.1093/ps/83.11.1839
La Grange L, Wang M, Watkins R, Ortiz D, Sanchez ME, Konst J, et al. Protective effects of the flavonoid mixture, silymarin, on fetal rat brain and liver. J Ethnopharmacol. 1999; 65(1):53- 61. https://doi.org/10.1016/S0378-8741(98)00144-5 DOI: https://doi.org/10.1016/S0378-8741(98)00144-5
Udapurkar PP, Bhusnure O, Kamble S, Biyani K. Phytophospholipid complex vesicles for phytoconstituents and herbal extracts: A promising drug delivery system. Int J Herbal Med. 2016; 4(5):14-20.
Fascina RM. Free radicals scavenging action and antienzyme activity of procyanidins from Vitis vinifera. A mechanism for their capillary protective action. Arzneimittelforschung. 1994; 44:592-601.
Phytosomes: A Technical Revolution on Phytomedicine. Available from: http://www.indena.com
Di Pierro F, Menghi AB, Barreca A, Lucarelli M, Calandrelli A. Green select phytosome as an adjunct to a low-calorie diet for treatment of obesity: A clinical trial. Altern Med Rev. 2009; 14(2):154-60.
Di Pierro F. Clinical efficacy of Greenselect® Phytosome® in patients affected by obesity. Integr Nutr. 2008; 11(2):15-21.
Marczylo TH, Verschoyle RD, Cooke DN, Morazzoni P, Steward WP, Gescher AJ. Comparison of systemic availability of curcumin with that of curcumin formulated with phosphatidylcholine. Cancer Chemother. 2007; 60:171-7. https://doi.org/10.1007/s00280-006-0355-x DOI: https://doi.org/10.1007/s00280-006-0355-x
Singh A, Saharan VA, Singh M, Bhandari A. Phytosome: drug delivery system for polyphenolic phytoconstituents. Iran J Pharm Sci. 2011; 7(4):209-19.
Semalty A. Cyclodextrin and phospholipid complexation in solubility and dissolution enhancement: a critical and meta-analysis. Expert Opinion on Drug Delivery. 2014; 11(8):1255-72. https://doi.org/10.1517/17425247.2014.916 271 DOI: https://doi.org/10.1517/17425247.2014.916271
Guha N, Paul A, Islam J, Das MK, Zaman MK. Phytosomes in functional cosmetics. In Nano cosmeceuticals. Academic Press. 2022. p. 237-75. https://doi.org/10.1016/B978-0-323- 91077-4.00001-6
Guha N, Paul A, Islam J, Das MK, Zaman MK. Phytosomes in functional cosmetics. In Nano cosmeceuticals. Academic Press. 2022. p. 237-75. https://doi.org/10.1016/B978-0-323- 91077-4.00001-6 DOI: https://doi.org/10.1016/B978-0-323-91077-4.00001-6
Farinacci M, Gaspardo B, Colitti M, Stefanon B. Dietary administration of curcumin modifies transcriptional profile of genes involved in inflammatory cascade in horse leukocytes. Ital J Anim Sci. 2009; 8(2):84-6. https://doi. org/10.4081/ijas.2009.s2.84 DOI: https://doi.org/10.4081/ijas.2009.s2.84
Kohli K, Ali J, Ansari MJ, Raheman Z. Curcumin: a natural anti-inflammatory agent. Indian J Pharmacol. 2005; 37(3):141. https://doi.org/10.4103/0253-7613.16209 DOI: https://doi.org/10.4103/0253-7613.16209
Di Pierro F, Menghi AB, Barreca A, Lucarelli M, Calandrelli A. Green Select (R) phytosome as an adjunct to a low-calorie diet for treatment of obesity: a clinical trial. Alternative Medicine Review. 2009; 14(2):154.
Gandhi A, Dutta A, Pal A, Bakshi P. Recent trends of phytosomes for delivering herbal extract with improved bioavailability. J Pharmacogn Phytochem. 2012; 1(4):06-14.
Mullaicharam AR, Deori G, Maheswari RU. Mini review on cosmeceuticals. Res J Pharm Bio and Chem Sci. 2013; 4(1):1091.
Singh A, Saharan VA, Singh M, Bhandari A. Phytosome: drug delivery system for polyphenolic phytoconstituents. Iran J Pharm Sci. 2011; 7(4):209-19.
Li Y, Yang DJ, Chen SL, Chen SB, Chan AS. Process parameters and morphology in puerarin, phospholipids and their complex microparticle generation by supercritical antisolvent precipitation. Int J Pharm. 2008; 359(1-2):35-45. https://doi.org/10.1016/j.ijpharm.2008.03.022 DOI: https://doi.org/10.1016/j.ijpharm.2008.03.022
Kidd PM. Phosphatidylcholine, is a superior protectant against liver damage. Altern Med Rev. 1996; 1(4):258-74.
Kuntal Maiti, Kakali Mukherjee, Arunava Gantait, Bishnu Pada Saha, Pulok K. Mukherjee. Enhanced therapeutic potential of naringenin-phospholipid complex in rats. 2006; 58(9):1227-1233. https://doi:10.1211/jpp.58.9.0009 DOI: https://doi.org/10.1211/jpp.58.9.0009
Bombardelli E, Bonati A, Gabetta B, Mustich G. Triterpenoids of Terminalia sericea. Phytochemistry. 1974; 13(11):2559- 62. https://doi.org/10.1016/S0031-9422(00)86936-8 DOI: https://doi.org/10.1016/S0031-9422(00)86936-8
Naik SR, Pilgaonkar VW, Panda VS. Evaluation of antioxidant activity of Ginkgo biloba phytosomes in rat brain. Phytotherapy Research: Phytotherapy Research. 2006; 20(11):1013-6. https://doi.org/10.1002/ptr.1976 DOI: https://doi.org/10.1002/ptr.1976
Jose MM, Bombardelli E. Pharmaceutical compositions containing flavanolignans and phospholipida active principles. US Patent EPO209037; 1987.
Rathore P, Swami G. Planterosomes: A potential phytophospholipid carriers for the bioavailability enhancement of herbal extracts. Int J Pharm Sci Res. 2012; 3(3):737.
Singh RP, Parpani S, Narke R, Chavan R. Phytosome: Recent advance research for novel drug delivery system. Asian J Pharm Res Dev. 2014. p. 15-29.
Hao H, Jia Y, Han R. Phytosomes: an effective approach to enhance the oral bioavailability of active constituents extracted from plants. J Chin Pharm Sci. 2013; 22(5):385- 92. https://doi.org/10.5246/jcps.2013.05.056
Ghanbarzadeh B, Babazadeh A, Hamishehkar H. Nanophytosome as a potential food-grade delivery system. Food Bioscience. 2016; 15:126-35. https://doi.org/10.1016/j. fbio.2016.07.006
Pathan RA, Bhandari U. Preparation and characterization of embelin–phospholipid complex as effective drug delivery tool. J Incl Phenom Macrocycl Chem. 2011; 69:139-47. https://doi.org/10.1007/s10847-010-9824-2 DOI: https://doi.org/10.1007/s10847-010-9824-2
Mazumder A, Dwivedi A, Du Preez JL, Du Plessis J. In vitro wound healing and cytotoxic effects of sinigrin–phytosome complex. Int J Pharm. 2016; 498(1-2):283-93. https://doi. org/10.1016/j.ijpharm.2015.12.027
Xu K, Liu B, Ma Y, Du J, Li G, Gao H, et al. Physicochemical properties and antioxidant activities of the luteolinphospholipid complex. Molecules. 2009; 14(9):3486-93. https://doi.org/10.3390/molecules14093486 DOI: https://doi.org/10.3390/molecules14093486
Hao H, Jia Y, Han R. Phytosomes: an effective approach to enhance the oral bioavailability of active constituents extracted from plants. J Chin Pharm Sci. 2013; 22(5):385- 92. https://doi.org/10.5246/jcps.2013.05.056 DOI: https://doi.org/10.5246/jcps.2013.05.056
Das MK, Kalita B. Design and evaluation of phytophospholipid complexes (phytosomes) of rutin for transdermal application. J Appl Pharm Sci. 2014; 4(10):051- 7. https://doi.org/10.7324/JAPS.2014.401010 DOI: https://doi.org/10.7324/JAPS.2014.401010
Mazumder A, Dwivedi A, Du Preez JL, Du Plessis J. In vitro wound healing and cytotoxic effects of sinigrin–phytosome complex. Int J Pharm. 2016; 498(1-2):283-93. https://doi. org/10.7324/JAPS.2014.401010 DOI: https://doi.org/10.1016/j.ijpharm.2015.12.027
Ghanbarzadeh B, Babazadeh A, Hamishehkar H. Nanophytosome as a potential food-grade delivery system. Food Bioscience. 2016; 15:126-35. https://doi.org/10.1016/j. fbio.2016.07.006 DOI: https://doi.org/10.1016/j.fbio.2016.07.006
Angelico R, Ceglie A, Sacco P, Colafemmina G, Ripoli M, Mangia A. Phyto-liposomes as nano shuttles for water-insoluble silybin–phospholipid complex. Int J Pharm. 2014; 471(1-2):173-81. https://doi.org/10.1016/j. ijpharm.2014.05.026 DOI: https://doi.org/10.1016/j.ijpharm.2014.05.026
Wang A, Wang CZ, Wu JA, Osinski J, Yuan CS. Determination of major ginsenosides in Panax quinquefolius (American ginseng) using high‐performance liquid chromatography. Phytochem Anal. 2005; 16(4):272- 7. https://doi.org/10.1002/pca.838 DOI: https://doi.org/10.1002/pca.838
Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature. 1994; 372(6505):425-32. https://doi.org/10.1038/372425a0 DOI: https://doi.org/10.1038/372425a0