Herbal Remedies for Osteoporosis
Authors
-
Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara - 391760, Gujarat, India ,IN
Maitri Mahant -
Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara - 391760, Gujarat, India ,INSweta B. Besh
-
Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara - 391760, Gujarat, India ,INDivya Kanojiya
-
Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara - 391760, Gujarat, India ,INCyril Sajan
-
Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara - 391760, Gujarat, India ,INHemrajsingh Rajput
-
Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara - 391760, Gujarat, India ,INRajesh A. Maheshwari
DOI:
https://doi.org/10.18311/jnr/2023/34056Keywords:
Bone Formation, Bone Resorption, Herbal Remedies, OsteoporosisAbstract
Osteoporosis is a widespread concern that poses significant health risks. In the past, it was commonly thought that women would naturally undergo this condition as they age, especially during menopause when hormonal imbalances heighten the risk. Osteoporotic fractures affect approximately one in three women and one in five men over the age of 50 during their lifetimes. The mature skeleton constantly undergoes a remodelling process that involves both bone formation and resorption. However, when bone resorption exceeds bone growth, osteoporosis develops. Both men and women need to prioritize their bone health throughout their lives. Addressing factors that impact bone health at every stage becomes crucial in preventing osteoporosis. To combat the rising incidence of osteoporotic fractures, it is crucial to implement effective preventive measures aimed at maximizing peak bone density, limiting accelerated bone loss, and reducing the risk of falls. Present therapy goals primarily focus on stopping further bone loss and fractures, preserving bone mass, and utilizing medications like bisphosphonates, Selective Estrogen Receptor Modulators (SERMs), anabolic steroids, strontium, and Hormonal Replacement Therapy (HRT). However, it’s worth noting that some of these treatments, such as HRT, bisphosphonates, SERMs, and anabolic steroids, may have negative side effects. As a result, there is an urgent need to identify effective, affordable, natural, and less harmful compounds to manage osteopenia/osteoporosis effectively. The search for safer alternatives is crucial in combating this condition and promoting better bone health.
Downloads
Metrics
Downloads
Published
How to Cite
License
Copyright (c) 2022 Maitri Mahant (Author); Sweta B. Besh; Divya Kanojiya, Cyril Sajan, Hemrajsingh Rajput (Author); Rajesh A. Maheshwari
This work is licensed under a Creative Commons Attribution 4.0 International License.
Accepted 2023-08-16
Published 2023-11-03
References
Wells B, DiPiro J, Schwinghammer T, DiPiro C. n.d. Pharmacotherapy handbook. 9th ed.
Sözen T, Özışık L, Başaran NÇ. An overview and management of osteoporosis. Eur J Rheumatol. 2017; 4(1):46. https://doi.org/10.5152/eurjrheum.2016.048 PMid: 28293453 PMCid:PMC5335887 DOI: https://doi.org/10.5152/eurjrheum.2016.048
Cosman F, de Beur SJ, LeBoff MS, Lewiecki EM, Tanner B, Randall S, et al. Clinician’s guide to prevention and treatment of osteoporosis. Osteopor Int. 2014; 25:2359-81. https://doi.org/10.1007/s00198014-2794-2 PMid:25182228 PMCid: PMC4176573 DOI: https://doi.org/10.1007/s00198-014-2794-2
Compston J, Bowring C, Cooper A, Cooper C, Davies C, Francis R, et al. Diagnosis and management of osteoporosis in postmenopausal women and older men in the UK: NOGG update 2013. Maturitas. 2013; 75(4):392-6. https://doi.org/10.1016/j.maturitas.2013.05.013 PMid:23810490 DOI: https://doi.org/10.1016/j.maturitas.2013.05.013
Crandall CJ, Newberry SJ, Diamant A, Lim YW, Gellad WF, Booth MJ, Motala A, Shekelle PG. Comparative effectiveness of pharmacologic treatments to prevent fractures: an updated systematic review. Ann Intern Med. 2014; 161(10):711-23. https://doi.org/10.7326/M14-0317 PMid:25199883 DOI: https://doi.org/10.7326/M14-0317
Raisz LG. Pathogenesis of osteoporosis: concepts, conflicts, and prospects. J Clin Invest. 2005; 115(12):331825. https://doi.org/10.1172/JCI27071 PMid:16322775 PMCid:PMC1297264 DOI: https://doi.org/10.1172/JCI27071
Parfitt AM, Villanueva AR, Foldes J, Rao DS. Relations between histologic indices of bone formation: implications for the pathogenesis of spinal osteoporosis. J Bone Miner Res. 1995; 10(3):466-73. https://doi.org/10.1002/jbmr.5650100319 PMid:7785469 DOI: https://doi.org/10.1002/jbmr.5650100319
Lee K, Jessop H, Suswillo R, Zaman G, Lanyon L. Bone adaptation requires oestrogen receptor-α. Nature. 2003; 424(6947):389. https://doi.org/10.1038/424389a PMid: 12879058 DOI: https://doi.org/10.1038/424389a
Lyles KW, Colón-Emeric CS, Magaziner JS, Adachi JD, Pieper CF, Mautalen C, et al. Zoledronic acid and clinical fractures and mortality after hip fracture. N Engl J Med 033. 2007; 357(18):1799-809. https://doi.org/10.1056/NEJMoa074941 PMid:17878149 PMCid:PMC2324066 DOI: https://doi.org/10.1056/NEJMoa074941
Colón‐Emeric CS, Mesenbrink P, Lyles KW, Pieper CF, Boonen S, Delmas P, et al. Potential mediators of the mortality reduction with zoledronic acid after hip fracture. J Bone Miner Res. 2010; 25(1):91-7. https://doi.org/10.1359/jbmr.090704 PMid:19580467 PMCid:PMC5770987 DOI: https://doi.org/10.1359/jbmr.090704
Aizer J, Bolster MB. Fracture liaison services: promoting enhanced bone health care. Curr Rheumatol Rep. 2014; 16:1-8. https://doi.org/10.1007/s11926-014-0455-2 PMid:25240684 DOI: https://doi.org/10.1007/s11926-014-0455-2
Lim SY, Bolster MB. Current approaches to osteoporosis treatment. Curr Opin Rheumatol. 2015; 27(3):216-24. https://doi.org/10.1097/BOR.0000000000000169 PMid: 25760281 DOI: https://doi.org/10.1097/BOR.0000000000000169
Neer RM, Arnaud CD, Zanchetta JR, Prince R, Gaich GA, Reginster JY, et al. Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis. N Engl J Med. 2001; 344(19):143441. https://doi.org/10.1056/NEJM200105103441904 PMid: 11346808 DOI: https://doi.org/10.1097/00006254-200110000-00018
Seeman E, Delmas PD. Bone quality—the material and structural basis of bone strength and fragility. N Engl J Med. 2006; 354(21):2250-61. https://doi.org/10.1056/NEJMra053077 PMid:16723616 DOI: https://doi.org/10.1056/NEJMra053077
Rossini M, Gatti D, Adami S. Involvement of WNT/βcatenin signalling in the treatment of osteoporosis. Calcif Tissue Int. 2013; 93:121-32. https://doi.org/10.1007/s00223013-9749-z PMid:23748710 DOI: https://doi.org/10.1007/s00223-013-9749-z
Boyce BF, Xing L. Biology of RANK, RANKL, and osteoprotegerin. Arthritis Res Ther. 2007; 9(1):1-7. DOI: https://doi.org/10.1186/ar2165
https://doi.org/10.1186/ar2104 PMid:17214881 PMCid: PMC1860057 DOI: https://doi.org/10.1186/ar2104
Bakhru HK. Herbs that heal: natural remedies for good health. Orient paperbacks; 1992.
Evelyn SS, Chitra V. Medicinal plants for the treatment of postmenopausal osteoporosis. Biomed Pharmacol J. 2019; 12(3):1561. https://doi.org/10.13005/bpj/1787 DOI: https://doi.org/10.13005/bpj/1787
Guo Y, Li Y, Xue L, Severino RP, Gao S, Niu J, et al. Salvia miltiorrhiza: An ancient Chinese herbal medicine as a source for anti-osteoporotic drugs. J Ethnopharmacol. 2014; 155(3):1401-16. https://doi.org/10.1016/j.jep.2014.07.058 PMid:25109459 DOI: https://doi.org/10.1016/j.jep.2014.07.058
Kawakita S, Marotta F, Naito Y, Gumaste U, Jain S, Tsuchiya J, et al. Effect of an isoflavones-containing red clover preparation and alkaline supplementation on bone metabolism in ovariectomized rats. Clin Interv Aging. 2009:91-100. https://doi.org/10.2147/CIA.S4164 PMid:19503771 PMCid:PMC2685230 DOI: https://doi.org/10.2147/CIA.S4164
Occhiuto F, Pasquale RD, Guglielmo G, Palumbo DR, Zangla G, Samperi S, et al. Effects of phytoestrogenic isoflavones from red clover (Trifolium pratense L) on experimental osteoporosis. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives. Phytother Res. 2007; 21(2):130-4. https://doi.org/10.1002/ ptr.2037 PMid:17117453 DOI: https://doi.org/10.1002/ptr.2037
Corletto F. Female climacteric osteoporosis therapy with titrated horsetail (Equisetum arvense) extract plus calcium (osteosil calcium): a randomized double-blind study. Miner Ortoped Traumatol. 1999; 50(5):201-6.
D’Souza J. Relieve it with a herb: horsetail for osteoporosis.
Mühlbauer RC, Lozano A, Palacio S, Reinli A, Felix R. Common herbs, essential oils, and monoterpenes potently modulate bone metabolism. Bone. 2003; 32(4):372-80.
https://doi.org/10.1016/S8756-3282(03)00027-9 PMid: 12689680 DOI: https://doi.org/10.1016/S8756-3282(03)00027-9
Rajkowska K, Kunicka-Styczyńska A, Maroszyńska M, Dąbrowska M. The effect of thyme and tea tree oils on morphology and metabolism of Candida albicans. Acta Biochimica Polonica. 2014; 61(2):305-10. https://doi.org/10.18388/abp.2014_1900 PMid:24918492 DOI: https://doi.org/10.18388/abp.2014_1900
Sienkiewicz M, Łysakowska M, Kowalczyk E, Szymańska G, Kochan E, Krukowska J, et al. The ability of selected plant essential oils to enhance the action of recommended antibiotics against pathogenic wound bacteria. Burns. 2017; 43(2):310-7. https://doi.org/10.1016/j.burns.2016.08.032 PMid:28341256 DOI: https://doi.org/10.1016/j.burns.2016.08.032
Elbahnasawy AS, Valeeva ER, El-Sayed EM, Rakhimov II. The impact of thyme and rosemary on prevention of osteoporosis in rats. J Nutr Metab. 2019. https://doi.org/10.1155/2019/1431384 PMid:31049223 PMCid: PMC6462344 DOI: https://doi.org/10.1155/2019/1431384
Chen Z, Xue J, Shen T, Mu S, Fu Q. Curcumin alleviates glucocorticoid-induced osteoporosis through the regulation of the Wnt signalling pathway. Int J Mol Med. 2016; 37(2):32938. https://doi.org/10.3892/ijmm.2015.2432 PMid:26677102 PMCid:PMC4716794 DOI: https://doi.org/10.3892/ijmm.2015.2432
Cho DC, Jung HS, Kim KT, Jeon Y, Sung JK, Hwang JH. Therapeutic advantages of treatment of high-dose curcumin in the ovariectomized rat. J Korean Neurosurg Soc. 2013; 54(6):461-6. https://doi.org/10.3340/jkns.2013.54.6.461 PMid: 24527187 PMCid:PMC3921272 DOI: https://doi.org/10.3340/jkns.2013.54.6.461
Kim WK, Ke K, Sul OJ, Kim HJ, Kim SH, Lee MH, et al. Curcumin protects against ovariectomy‐induced bone loss and decreases osteoclastogenesis. J Cell Biochem. 2011; 112(11):3159-66. https://doi.org/10.1002/jcb.23242 PMid:21732406 DOI: https://doi.org/10.1002/jcb.23242
Pop G. A screening for the most representative classes of compounds from two varieties of soy.
Yang MW, Wang TH, Yan PP, Chu LW, Yu J, Gao ZD, et al. Curcumin improves bone microarchitecture and enhances mineral density in APP/PS1 transgenic mice. Phytomedicine. 2011; 18(2-3):205-13. https://doi.org/10.1016/j.phymed.2010.05.011 PMid:20637579 DOI: https://doi.org/10.1016/j.phymed.2010.05.011
Ain HB, Saeed F, Kashif M, Tufail T, Suleria HA. Nutritional Aspects of Soybean (Glycine Max). InBioactive Compounds from Multifarious Natural Foods for Human Health. Apple Academic Press. 2022; p. 3-19. https://doi.org/10.1201/9781003189763-2 DOI: https://doi.org/10.1201/9781003189763-2
Gupta L, Srivastava M. Effect of Withania somnifera. 2008. pp. 190-2.
Singh N, Bhalla M, de Jager P, Gilca M. Singh, et al. Afr J Tradit Complement Altern Med. 2011; 8(S):208-213. https://doi.org/10.4314/ajtcam.v8i5S.9 PMid:22754076 PMCid:PMC3252722 DOI: https://doi.org/10.4314/ajtcam.v8i5S.9
Kaur J, Sharma G, Mahajan A, Katare OP, Bhadada SK, Ghoshal G. Role of Cissus quadrangularis in the Management of Osteoporosis: An Overview. Crit Rev Ther Drug Carr Syst. 2021; 38(5). https://doi.org/10.1615/CritRevTherDrugCarrierSyst.2021033808 PMid:34375512 DOI: https://doi.org/10.1615/CritRevTherDrugCarrierSyst.2021033808
Thakur S, Kaurav H, Chaudhary G. Terminalia arjuna: a potential ayurvedic cardio tonic. Int J Res Appl Sci Biotechnol. 2021; 8(2):227-36. https://doi.org/10.31033/ijrasb.8.2.30 DOI: https://doi.org/10.31033/ijrasb.8.2.30
Dwivedi S, Udupa N. Terminalia arjuna: pharmacognosy, phytochemistry, pharmacology and clinical use. A review. Fitoterapia. 1989; 60(5):413-20.
Lin TC, Chien SC, Chen HF, Hsu FL. Tannins and related compounds from Combretaceae plants. Chin Pharm J. 2000; 52(1):1-26.
Chopra RN, Ghosh S. Terminalia arjuna: its chemistry, pharmacology and therapeutic action. Indian Med Gaz1. 929; 64(2):70.
Trivedi A, Katti HR, Shalavadi MH, Ramkishan A, Chandrashekhar VM. The anti-osteoporotic activity of ethanol extract of Terminalia arjuna (Roxb.) Wight & Arn. on ovariectomized rats.
Narzary D, Rana TS, Ranade SA. Genetic diversity in intersimple sequence repeat profiles across natural populations of Indian pomegranate (Punica granatum L.). Plant Biol. 2010; 12(5):806-13. https://doi.org/10.1111/j.14388677.2009.00273.x PMid:20701705 DOI: https://doi.org/10.1111/j.1438-8677.2009.00273.x
Yogesh HS. Evaluation of the antiosteoporosis activity of ethanolic extract of Punica granatum Linn. seeds in ovariectomized-induced osteoporosis rats. Int J Green Pharm. 2020; 14(1).
Mittal J, Sharma MM, Batra A. Tinospora cordifolia: a multipurpose medicinal plant-A. J Med Plants. 2014; 2(2).
Shubhashree MN, Naik R, Doddamani SH, Bhat S. An updated review of single herbal drugs in the management of osteoporosis. Int J Complement Altern Med. 2018; 11:826. https://doi.org/10.15406/ijcam.2018.11.00372 DOI: https://doi.org/10.15406/ijcam.2018.11.00372
Abiramasundari G, Sumalatha KR, Sreepriya M. Effects of Tinospora cordifolia (Menispermaceae) on the proliferation, osteogenic differentiation, and mineralization of osteoblast model systems in vitro. J Ethnopharmacol. 2012; 141(1):474-80. https://doi.org/10.1016/j.jep.2012.03.015 PMid:22449439 DOI: https://doi.org/10.1016/j.jep.2012.03.015
Abiramasundar G, Sreepriya M. Pro-Stimulatory Effects of Tinospora cordifolia (Menispermaceae) on SAOS-2 osteoblast cells-implications on bone remodelling and therapy of osteoporosis. Res J Pharma Biol Chem Sci. 2014; 5(3):354-63.
Goreja WG. Black seed. Nature’s miracle, remedy amazing herbs Press, New York. 2003; p. 1-64.
Shuid AN, Mohamed N, Mohamed IN, Othman F, Suhaimi F, Mohd Ramli ES, et al. Nigella sativa: A potential antiosteoporotic agent. Evid-based Complement Altern Med. 2012. https://doi.org/10.1155/2012/696230 PMid:22973403 PMCid:PMC3438907 DOI: https://doi.org/10.1155/2012/696230
Ali MA, Sayeed MA, Alam MS, Yeasmin MS, Khan AM, Muhamad II. Characteristics of oils and nutrient contents of Nigella sativa Linn. and Trigonella foenum graecum seeds. Bull Chem Soc Ethiop. 2012; 26(1). https://doi.org/10.4314/bcse.v26i1.6 DOI: https://doi.org/10.4314/bcse.v26i1.6
Carrillo C, Cavia MD, Alonso-Torre SR. Oleic acid inhibits store-operated calcium entry in human colorectal adenocarcinoma cells. Eur J Nutr. 2012; 51:677-84. https://doi.org/10.1007/s00394-011-0246-8 PMid:21956128 DOI: https://doi.org/10.1007/s00394-011-0246-8
Martin-Bautista E, Muñoz-Torres M, Fonolla J, Quesada M, Poyatos A, Lopez-Huertas E. Improvement of bone formation biomarkers after 1-year consumption with milk fortified with eicosapentaenoic acid, docosahexaenoic acid, oleic acid, and selected vitamins. Nutr Res. 2010; 30(5):320-6. https://doi.org/10.1016/j.nutres.2010.05.007 PMid:20579524 DOI: https://doi.org/10.1016/j.nutres.2010.05.007
Seif AA. Nigella sativa reverses osteoporosis in ovariectomized rats. BMC Complement Altern Med.
; 14:1-8. https://doi.org/10.1186/1472-6882-14-22 PMid:24422662 PMCid:PMC3898005 DOI: https://doi.org/10.1186/1472-6882-14-22
Kiyama R. Nutritional implications of ginger: Chemistry, biological activities, and signalling pathways. J Nutr Biochem. 2020; 86:108486. https://doi.org/10.1016/j.jnutbio.2020.108486 PMid:32827666 DOI: https://doi.org/10.1016/j.jnutbio.2020.108486
Funk JL, Frye JB, Wright LE, Timmermann BN. Effects of ginger (Zingiber officialis L) on inflammation‐induced bone loss.
Fan JZ, Yang X, Bi ZG. The effects of 6-gingerol on proliferation, differentiation, and maturation of
osteoblast-like MG-63 cells. Braz J Med Biol Res. 2015; 48:637-43.
https://doi.org/10.1590/1414-431x20154494 PMid:25923459 PMCid:PMC4512103 DOI: https://doi.org/10.1590/1414-431x20154494
Sinaga M, Ganesan K, Nair SK, Gani SB. Preliminary phytochemical analysis and in vitro antibacterial activity of bark and seeds of Ethiopian neem (Azadirachta indica A. Juss). World J Pharm Pharm Sci. 2016; 5:1714-23.
Kuete V, Tangmouo J, Penlap Beng V, Ngounou F, Lontsi D. Antimicrobial activity of the methanolic extract from the stem bark of Tridesmostemon omphalocarpoides (Sapotaceae). J Ethnopharmacol. 2006; 104:5-11. https://doi.org/10.1016/j.jep.2005.08.002 PMid:16413717 DOI: https://doi.org/10.1016/j.jep.2005.08.002
Britannica T. Editors of encyclopaedia. Argon. Encyclopedia Britannica. 2020.
Boulbaroud S, Mesfioui A, Arfaoui A, Ouichou A, El-Hessni A. Preventive effects of flaxseed and sesame oil on bone loss in ovariectomized rats. Pak J Biol Sci. 2008; 11(13):1696-701. https://doi.org/10.3923/pjbs.2008.1696.1701 PMid:18819621 DOI: https://doi.org/10.3923/pjbs.2008.1696.1701
Patel C, Ayaz RM, Parikh P. Studies on the osteoprotective and antidiabetic activities of Moringa oleifera plant extract. IOSR J Pharm Biol Sci. 2015; 5:19-22.
Mahmood KT, Mugal T, Haq IU. Moringa oleifera: A natural gift-A review. J Pharm Sci Res. 2010; 2(11):775.
Goyal RK, Singh J, Lal H. Asparagus racemosus - an update. Indian J Med Sci. 2003; 57(9):408-14.
Chitme HR, Muchandi IS, Burli SC. Effect of Asparagus racemosus Willd root extract on ovariectomized
rats. The Open Nat Prod J. 2009; 2(1). https://doi.org/10.2174/1874848100902010016 DOI: https://doi.org/10.2174/1874848100902010016
Bhatt P, Kushwah AS. Rubia cordifolia overview: A new approach to treat cardiac disorders. Int J Drug Dev Res. 2013; 5(2):47-54.
Wu YB, Zheng CJ, Qin LP, Sun LN, Han T, Jiao L, et al. The antiosteoporotic activity of anthraquinones from Morinda officinalis on osteoblasts and osteoclasts. Mol. 2009; 14(1):573-83. https://doi.org/10.3390/molecules14010573 PMid:19169204 PMCid:PMC6253840 DOI: https://doi.org/10.3390/molecules14010573
Shivakumar K, Mukund H, Rabin P. Evaluation of antiosteoporotic activity of root extract of Rubia cordifolia in ovariectomized rats. Int J Drug Dev Res. 2012; 4(3):163-72.
0.35
24
0.161