Wound Healing Activity of the Galls of Quercus infectoria Olivier

Abstract

Objective: To screen the wound healing activity of different extracts of galls of Quercus infectoria on incision, excision and dead space (granulation) wound models in albino rats. Materials and method: Crude aqueous extract of Quercus infectoria galls and its three different crude fractions, petroleum ether (40°-60°C), solvent ether, ethyl acetate were tested for various preliminary phytoconstituents and were screened at dose of 100mg/kg for wound healing properties in incision, excision and dead space (granulation) wound models in albino rats. Results: Tannins, flavonoids, steroids and carbohydrates were found to be present in aqueous extract and its various fractions of galls of Quercus infectoria. In resutured incision wound models aqueous extract and its fractions showed significant (P<0.01) breaking strength compared to control. In excision wound parameters the aqueous extract promotes better wound healing (96.36%) compared to control and organic fractions. Breaking strength of the grass pith induced granuloma studies the results show significant (P<0.01) activity in case of aqueous extract along with solvent ether fraction. Conclusion: From the results obtained, it can be observed that aqueous extract and its fractions of galls of Quercus infectoria have significant wound healing property. Also it can be concluded that flavonoids may be responsible for wound healing activity.