Effect of Lawsonia alba Leaf Extracts on Carbon Tetrachloride-Induced Hepatic Damage in Albino Rats

Abstract

Objectives: To screen the hepatoprotective activity of leaves of Lawsonia alba against carbon tetrachloride induced hepatotoxicity in albino rats. Method: Studies on the hepatoprotective activity of the leaves of Lawsonia alba were carried out in albino rats. The Lawsonia alba leaf ethanolic extract and three different fractions obtained from it were screened for hepatoprotective activity using carbon tetrachloride-induced hepatic damage model in rats. Doses for the different fractions and ethanolic extract were selected based on the results of acute toxicity studies in mice. The effect was assessed by serum enzyme profile, viz., glutamic oxaloacetate transaminase (GOT) and glutamic pyruvate transaminase (GPT) levels, and histopathological changes in liver. Results: Lawsonia alba ethanolic extract significantly protected from biochemical and histological changes induced by carbontetrachloride in rats. Conclusion: Ethanolic extract of Lawsonia alba leaves exhibited a significant protection against carbon tetrachloride-induced hepatic damage in rats.