Emblica officinalis Gaertn. (Amalaki): A Natural Herbal Remedy to Enhance Cardiorespiratory Fitness in Ayurveda - An In Silico Molecular Docking Approach

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Authors

  • Amal S. Chandran
     Department of Swasthavritta, KLE Academy of Higher Education and Research’s Shri B. M. Kankanawadi Ayurveda Mahavidyalaya, Belagavi – 590003, Karnataka, India ,IN ORCID logo https://orcid.org/0000-0001-7839-9507
  • Ashok Patil
     Department of Swasthavritta, KLE Academy of Higher Education and Research’s Shri B. M. Kankanawadi Ayurveda Mahavidyalaya, Belagavi – 590003, Karnataka, India ,IN
  • Sanjiv Kumar
     Department of Neurophysiotherapy, KLE Academy of Higher Education and Research’s Institute of Physiotherapy, Belagavi – 590010, Karnataka, India ,IN ORCID logo https://orcid.org/0000-0002-4080-1414
  • Krishika Muralidharan
     Department of Rasayana Evam Vajeekarana, KLE Academy of Higher Education and Research's Shri B. M. Kankanawadi Ayurveda Mahavidyalaya, Belagavi – 590003, Karnataka, India ,IN
  • Sreeja V. Kaimal
     Department of Rasashastra and Bhaishajya Kalpana, KLE Academy of Higher Education and Research’s Shri B. M. Kankanawadi Ayurveda Mahavidyalaya, Belagavi – 590003, Karnataka, India ,IN

DOI:

https://doi.org/10.18311/jnr/2023/34637

Keywords:

Aerobic Fitness, Endurance, Molecular Docking, Network Pharmacology, Stamina, Strength

Abstract

Background: Cardiorespiratory fitness is the capacity of the circulatory and respiratory systems to transport oxygen to the skeletal muscle mitochondria for energy production during physical activity. Cardiorespiratory fitness has been recognized as a vital health biomarker and is very crucial for sports persons. Physical activities, aerobic exercise, yoga, meditation, nutritional supplements, and ergogenic aids are the ways to enhance cardiorespiratory fitness. Emblica officinalis Gaertn. is one of the widely used drugs in Ayurveda traditional medicine to enhance Cardiorespiratory Fitness (CRF). However, there is a dearth of clear information regarding how Emblica officinalis can improve CRF. Objective: The current in silico molecular docking study was planned to identify the phytochemicals, and targets of endurance and predict the probable mode of action of the drug and thereby substantiate the ability of Emblica officinalis as a natural and ethical way of enhancing cardiorespiratory fitness. Methods: The phytochemicals and targets are collected from reliable sources, and the effectiveness of these gene targets was validated using network pharmacology ligand-target interaction methods. The Protein Data Bank and PubChem were used to find the ligands and targets, and PyRx was used to do docking. Conclusion: Emblica officinalis is found to have a positive influence on the 12 metabolic pathways that act in enhancing the cardiorespiratory endurance in the human being. PRKCA was analyzed and concluded as the highly modulated gene target with the lowest binding energy. Thus, Emblica officinalis was found to have an action in enhancing cardio-respiratory endurance.

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Author Biography

Amal S. Chandran, Department of Swasthavritta, KLE Academy of Higher Education and Research’s Shri B. M. Kankanawadi Ayurveda Mahavidyalaya, Belagavi – 590003, Karnataka, India

  

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Published

2023-10-31

How to Cite

Chandran, A. S., Patil, A., Kumar, S., Muralidharan, K., & Kaimal, S. V. (2023). <i>Emblica officinalis</i> Gaertn. (<i>Amalaki</i>): A Natural Herbal Remedy to Enhance Cardiorespiratory Fitness in <i>Ayurveda</i> - An <i>In Silico</i> Molecular Docking Approach. Journal of Natural Remedies, 23(4), 1615–1630. https://doi.org/10.18311/jnr/2023/34637

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Volume 23 Issue 4 October 2023

Section

Short Communication

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Copyright (c) 2023 Amal S. Chandran, Ashok Patil, Sanjiv Kumar, Krishika Muralidharan, Sreeja V. Kaimal (Author)

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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Received 2023-08-12
Accepted 2023-09-14
Published 2023-10-31

 

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