The Nexus between Polyphenols and Gut Microbiota and Their Interplay in Human Health: A Brief Review
Authors
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Department of Pharmacology, Krupanidhi College of Pharmacy, Bengaluru - 560035, Karnataka ,IN
K. J. Albin -
Department of Pharmacology, Krupanidhi College of Pharmacy, Bengaluru - 560035, Karnataka ,INP. N. Nimith Noble
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Department of Pharmacology, Krupanidhi College of Pharmacy, Bengaluru - 560035, Karnataka ,INN. Prem Kumar
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Department of Microbiology, Krupanidhi Degree College, Bengaluru - 560035, Karnataka ,INKhalid Imran
DOI:
https://doi.org/10.18311/jnr/2024/35974Keywords:
Dietary Intake, Functional Food, Gut Microbes, Human Health, Polyphenols, PhytochemicalsAbstract
Polyphenols are a broad class of naturally occurring substances in plants and have drawn extensive attention as they may possess promising health-promoting benefits. Recently, gut microbiota and polyphenol interactions have been directly linked to the well-being of humans. The classification, sources, and interactions of polyphenols with the gut microbiota are presented in this review, highlighting their key health benefits in humans. Polyphenols undergo complex transformations within the gastrointestinal tract and interact with the gut microbiota, a varied collection of bacteria living in the digestive system. The interactions substantially influence the composition, functioning, metabolic activity, and gut microbiota diversity. Research indicates that polyphenols may possess prebiotic-like properties, favouring Lactobacilli and Bifidobacteria growth, among other beneficial bacteria. The fermentation of polyphenols is aided by these bacteria, which produce bioactive metabolites that may improve human health and well-being in various ways. Moreover, the alteration of gut microbiology caused by polyphenols has been linked to improvements in several health outcomes, including enhanced metabolic health, fortified immunological function, and a decreased susceptibility to chronic conditions like heart disease and certain forms of cancer. In summary, the intriguing relationship between polyphenols and gut microbiota has significant health implications for humans. Understanding these relationships can open the door to tailored dietary treatments and the development of functional foods to support a balanced gut microbiota and general well-being.
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Copyright (c) 2024 K. J. Albin, P. N. Nimith Noble, N. Prem Kumar, Khalid Imran (Author)
This work is licensed under a Creative Commons Attribution 4.0 International License.
Accepted 2024-07-18
Published 2024-10-07
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