Hepatoprotective Activity of Haritaki (Terminalia chebula Retz): A Systematic Review

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Authors

  • Anjali Katore
     Department of Rasashastra and Bhaishajya Kalpana, Mahatma Gandhi Ayurved College Hospital and Research Centre, Datta Meghe Institute of Higher Education and Research (Deemed to be University), Wardha – 442107, Maharashtra ,IN
  • Anita Wanjari
     Department of Rasashastra and Bhaishajya Kalpana, Mahatma Gandhi Ayurved College Hospital and Research Centre, Datta Meghe Institute of Higher Education and Research (Deemed to be University), Wardha – 442107, Maharashtra ,IN
  • Bharat Rathi
     Department of Rasashastra and Bhaishajya Kalpana, Mahatma Gandhi Ayurved College Hospital and Research Centre, Datta Meghe Institute of Higher Education and Research (Deemed to be University), Wardha – 442107, Maharashtra ,IN
  • Manasi Chunchuwar
     Department of Rasashastra and Bhaishajya Kalpana, Mahatma Gandhi Ayurved College Hospital and Research Centre, Datta Meghe Institute of Higher Education and Research (Deemed to be University), Wardha – 442107, Maharashtra ,IN
  • Aditi Shinde
     Department of Rasashastra and Bhaishajya Kalpana, Mahatma Gandhi Ayurved College Hospital and Research Centre, Datta Meghe Institute of Higher Education and Research (Deemed to be University), Wardha – 442107, Maharashtra ,IN
  • Payal Raut
     Department of Rasashastra and Bhaishajya Kalpana, Mahatma Gandhi Ayurved College Hospital and Research Centre, Datta Meghe Institute of Higher Education and Research (Deemed to be University), Wardha – 442107, Maharashtra ,IN
  • Harlin Swer
     Department of Rasashastra and Bhaishajya Kalpana, Mahatma Gandhi Ayurved College Hospital and Research Centre, Datta Meghe Institute of Higher Education and Research (Deemed to be University), Wardha – 442107, Maharashtra ,IN

DOI:

https://doi.org/10.18311/jnr/2024/36004

Keywords:

Terminalia chebula Retz, Hepatoprotective, In Vitro Study, In Vivo Study, Haritaki

Abstract

Terminalia chebula Retz, also referred as Haritaki in Sanskrit, is a widely available plant distributed all over India. T. chebula has been widely acknowledged for its therapeutic qualities and application in treating several kinds of diseases. This plant is part of the Combretaceae family and serves a crucial role in maintaining a disease-free community. The hepatoprotective qualities of T. chebula are widely recognized. Consequently, published literature from “Pubmed, Scopus, Cochrane database, Google Scholar” up to 2023 was used in a systematic review. With a computer-based search engine, 115 Studies in total were looked up. In the present study, T. chebula’s hepatoprotective properties were investigated using PubMed, Scopus, Cochrane and other resources. Twelve studies that met the requirements were chosen after screening. To identify the various activities, T. chebula plant leaves, fruits, roots, and polymer were examined. This systematic review aimed to collect and analyze data on the efficacy of T. chebula as a hepatoprotective treatment from clinical trials, in vivo investigations, and in vitro experiments. The 12 studies that were chosen had significantly different study designs and results. The study concludes that T. chebula provides alternatives for several medical disciplines due to its hepatoprotective and diseaseprevention qualities.

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Published

2024-11-06

How to Cite

Katore, A., Wanjari, A., Rathi, B., Chunchuwar, M., Shinde, A., Raut, P., & Swer, H. (2024). Hepatoprotective Activity of <i>Haritaki</i> (<i>Terminalia chebula</i> Retz): A Systematic Review. Journal of Natural Remedies, 24(10), 2131–2141. https://doi.org/10.18311/jnr/2024/36004

Issue

Volume 24, Issue 10, October 2024

Section

Short Review

Categories

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Copyright (c) 2024 Anjali Katore, Anita Wanjari, Bharat Rathi, Manasi Chunchuwar, Aditi Shinde, Payal Raut, Harlin Swer (Author)

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Crossref
Scopus
Google Scholar
Europe PMC
Received 2023-12-29
Accepted 2024-07-15
Published 2024-11-06

 

References

Edwards L, Wanless IR. Mechanisms of liver involvement in systemic disease. Best Practice and Research Clinical Gastroenterology. 2013; 27(4):471-83. https://doi.org/10.1016/j.bpg.2013.08.002

Kim TY, Kim DJ. Acute-on-chronic liver failure. Clinical and molecular hepatology. 2013; 19(4):349. https://doi.org/10.3350/cmh.2013.19.4.349

Bernal W, Auzinger G, Dhawan A, Wendon J. Acute liver failure. The Lancet. 2010; 376(9736):190-201. https://doi.org/10.1016/S0140-6736(10)60274-7

Wei L, Ren F, Zhang X, Wen T, Shi H, Zheng S, Zhang J, Chen Y, Han Y, Duan Z. Oxidative stress promotes D-GalN/ LPS-induced acute hepatotoxicity by increasing glycogen synthase kinase 3β activity. Inflammation Research. 2014; 63:485-94. https://doi.org/10.1007/s00011-014-0720-x

Klaunig JE, Xu Y, Isenberg JS, Bachowski S, Kolaja KL, Jiang J, Stevenson DE, Walborg Jr EF. The role of oxidative stress in chemical carcinogenesis. Environmental Health Perspectives. 1998; 106(1):289-95. https://doi.org/10.1289/ ehp.98106s1289

Jaeschke H, McGill MR, Ramachandran A. Oxidant stress, mitochondria, and cell death mechanisms in druginduced liver injury: lessons learned from acetaminophen hepatotoxicity. Drug Metabolism Reviews. 2012; 44(1):88106. https://doi.org/10.3109/03602532.2011.602688

Negi AS, Kumar JK, Luqman S, Shanker K, Gupta MM, Khanuja SP. Recent advances in plant hepatoprotectives: a chemical and biological profile of some important leads. Medicinal Research Reviews. 2008; 28(5):746-72. https://doi.org/10.1002/med.20115

Comelli MC, Mengs U, Schneider C, Prosdocimi M. Toward the definition of the mechanism of action of silymarin: activities related to cellular protection from toxic damage induced by chemotherapy. Integrative Cancer Therapies. 2007; 6(2):120-9. https://doi.org/10.1177/1534735407302349

Gonzalez-Burgos E, Gomez-Serranillos MP. Terpene compounds in nature: a review of their potential antioxidant activity. Current Medicinal Chemistry. 2012; 19(31):531941. https://doi.org/10.2174/092986712803833335

Ai G, Liu Q, Hua W, Huang Z, Wang D. Hepatoprotective evaluation of the total flavonoids extracted from flowers of Abelmoschus manihot (L.) Medic: In vitro and in vivo studies. Journal of Ethnopharmacology. 2013; 146(3):794802. https://doi.org/10.1016/j.jep.2013.02.005

Lee WM. Acute liver failure. In seminars in respiratory and critical care medicine. 2012; 33(1): 36-45. Thieme Medical Publishers. https://doi.org/10.1055/s-0032-1301733

Muhammad S, Khan BA, Akhtar N, Mahmood T, Rasul A, Hussain I, Khan H, Badshah A. The morphology, extractions, chemical constituents and uses of Terminalia chebula: A review. J Med Plants Res. 2012; 6(33):4772-5. https://doi.org/10.5897/JMPR11.1339

Mishra P, Kumar A, Nagireddy A, Shukla AK, Sundaresan V. Evaluation of single and multilocus DNA barcodes towards species delineation in complex tree genus Terminalia. PloS one. 2017; 12(8):e0182836. https://doi.org/10.1371/journal.,pone.0182836

Edwin-Wosu NL, Omara-Achong T, Nyannanyo BL. ecogeographical amplitude and habitat of two species of the genus-Terminalia (Combretaceae) in the central niger delta areas in rivers state. Journal of Applied Sciences and Environmental Management. 2013; 17(1):75-80.

Gupta PC. Biological and pharmacological properties of Terminalia chebula Retz.(Haritaki) - An overview. Int J pharm Sci. 2012; 4(3):62-8.

Albagouri AH, Elegami AA, Koko WS, Osman EE, Dahab MM. In vitro anticercarial activities of some Sudanese medicinal plants of the family Combretaceae. J Forest Products Industries. 2014; 3(2):93.

Nithaniyal S, Parani M. Evaluation of chloroplast and nuclear DNA barcodes for species identification in Terminalia L. Biochemical Systematics and Ecology. 2016; 68:223-9. https://doi.org/10.1016/j.bse.2016.08.001

Ohri D. Genome size and polyploidy variation in the tropical hardwood genus Terminalia (Combretaceae). Plant Systematics and Evolution. 1996; 200:225-32. https:// doi.org/10.1007/BF00984937

Deb A, Barua S, Das B. Pharmacological activities of Baheda (Terminalia bellerica): a review. Journal of Pharmacognosy and Phytochemistry. 2016; 5(1):194-7.

Saxena VA, Mishra G, Saxena A, Vishwakarma KR. A comparative study on quantitative estimation of tannins in Terminalia chebula, Terminalia belerica, Terminalia arjuna and Saraca indica using spectrophotometer. Asian Journal of Pharmaceutical and Clinical Research. 2013; 6(3):148-9.

Rao P. Antioxidant effect of Triphala-critical review. Journal of Ayurveda and Integrated Medical Sciences. 2017; 2(1):213-9. https://doi.org/10.21760/jaims.v2i1.7513

Prasad K. Responses of dual inoculation of arbuscular mycorrhizal fungi on the biomass production, phosphate, roots, and shoot phenol concentrations of Terminalia arjuna under field conditions. Taxonomic series: Glomus from Goa. 1987; 29:13.

Zhang XR, Kaunda JS, Zhu HT, Wang D, Yang CR, Zhang YJ. The genus Terminalia (Combretaceae): An ethnopharmacological, phytochemical and pharmacological review. Natural Products and Bioprospecting. 2019; 9:357-92. https://doi.org/10.1007/ s13659-019-00222-3

Das B, Dash S, Choudhury RC. Pharmaceutical properties of Terminalia bellerica (bahera)-an overview. Research Journal of Pharmacy and Technology. 2014; 7(5):592-7.

Nigam M, Mishra AP, Adhikari‐Devkota A, Dirar AI, Hassan MM, Adhikari A, Belwal T, Devkota HP. Fruits of Terminalia chebula Retz.: A review on traditional uses, bioactive chemical constituents and pharmacological activities. Phytotherapy Research. 2020; 34(10):2518-33. https://doi.org/10.1002/ptr.6702

Cock IE. The medicinal properties and phytochemistry of plants of the genus Terminalia (Combretaceae). In flammo pharmacology. 2015; 23:203-29. https://doi.org/10.1007/ s10787-015-0246-z

Sarwat M, Das S, Srivastava PS. Estimation of genetic diversity and evaluation of relatedness through molecular markers among medicinally important trees: Terminalia arjuna, T. chebula and T. bellerica. Molecular Biology Reports. 2011; 38:5025-36. https://doi.org/10.1007/s11033-010-0649-2

Kanpipith N, Pangkruang W, Kiyotaka K, Puthongking P. Antioxidant and anti-angiogenesis properties of Terminalia bellerica (Gaertn.) Roxb. and Terminalia chebula (Retz.) crude extracts. Planta Medica. 2013; 79(13). https://doi.org/10.1055/s-0033-1352227

Hedina A, Kotti P, Kausar J, Anand V. Phytopharmacological overview of Terminalia chebula Retz. Pharmacognosy Journal., 2016; 8(4). https://doi.org/10.5530/pj.2016.4.1

Virshette SJ, Patil MK, Shaikh JR. A review on pharmacological properties and phytoconstituents of indigenous carminative agents. Journal of Pharmacognosy and Phytochemistry. 2020; 9(3):142-5.

Sharma A, Chandraker S, Patel VK, Ramteke P. Antibacterial activity of medicinal plants against pathogens causing complicated urinary tract infections. Indian Journal of Pharmaceutical Sciences. 2009 ;71(2):136. https://doi.org/10.4103/0250-474X.54279

Gupta PC. Biological and pharmacological properties of Terminalia chebula Retz. (Haritaki)-An overview. Int J Pharm Sci. 2012; 4(3):62-8.

Upadhyay A, Agrahari P, Singh DK. A review on the pharmacological aspects of Terminalia chebula. Int J Pharmacol. 2014; 10(6):289-98. https://doi.org/10.3923/ijp.2014.289.298

Jaiswal Y, Liang Z, Zhao Z. Botanical drugs in Ayurveda and traditional Chinese medicine. Journal of Ethnopharmacology. 2016; 194:245-59. https://doi.org/10.1016/j.jep.2016.06.052

Bag A, Bhattacharyya SK, Chattopadhyay RR. The development of Terminalia chebula Retz. (Combretaceae) in clinical research. Asian Pacific Journal of Tropical Biomedicine. 2013; 3(3):244-52. https://doi.org/10.1016/S2221-1691(13)60059-3

Gupta PC. Biological and pharmacological properties of Terminalia chebula Retz. (Haritaki)-An overview. Int J Pharm Sci. 2012; 4(3):62-8.

Wei L, Ren F, Zhang X, Wen T, Shi H, Zheng S, Zhang J, Chen Y, Han Y, Duan Z. Oxidative stress promotes D-GalN/ LPS-induced acute hepatotoxicity by increasing glycogen synthase kinase 3β activity. Inflammation Research. 2014; 63:485-94. https://doi.org/10.1007/s00011-014-0720-x

Klaunig JE, Xu Y, Isenberg JS, Bachowski S, Kolaja KL, Jiang J, Stevenson DE, Walborg Jr EF. The role of oxidative stress in chemical carcinogenesis. Environmental Health Perspectives. 1998; 106:289-95. https://doi.org/10.1289/ ehp.98106s1289

Jaeschke H, McGill MR, Ramachandran A. Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity. Drug Metabolism Reviews. 2012; 44(1):88106. https://doi.org/10.3109/03602532.2011.602688

Negi AS, Kumar JK, Luqman S, Shanker K, Gupta MM, Khanuja SP. Recent advances in plant hepatoprotectives: a chemical and biological profile of some important leads. Medicinal Research Reviews. 2008; 28(5):746-72. https://doi.org/10.1002/med.20115

Comelli MC, Mengs U, Schneider C, Prosdocimi M. Toward the definition of the mechanism of action of silymarin: activities related to cellular protection from toxic damage induced by chemotherapy. Integrative Cancer Therapies. 2007; 6(2):120-9. https://doi.org/10.1177/1534735407302349

Gonzalez-Burgos E, Gomez-Serranillos MP. Terpene compounds in nature: a review of their potential antioxidant activity. Current Medicinal Chemistry. 2012; 19(31):531941. https://doi.org/10.2174/092986712803833335

Tasduq SA, Singh K, Satti NK, Gupta DK, Suri KA, Johri RK. Terminalia chebula (fruit) prevents liver toxicity caused by sub-chronic administration of rifampicin, isoniazid and pyrazinamide in combination. Human and Experimental Toxicology. 2006; 25(3):111-8. https://doi.org/10.1191/0960327106ht601oa

Sharma A, Rathore HS. Prevention of acetaminophen induced hepatorenal toxicity in mice with fruits of Terminalia chebula (Myrobalan). Thai Journal of Toxicology. 2010; 25(2):144.

Sivachandran M, Hariharan P. Renoprotective effect of Terminalia chebula on gentamicin-induced toxicity in rats.

Sarkar R, Hazra B, Mandal N. Reducing power and iron chelating property of Terminalia chebula (Retz.) alleviates iron-induced liver toxicity in mice. BMC Complementary and Alternative Medicine. 2012; 12:1-0. https://doi.org/10.1186/1472-6882-12-144

Nishanth RP, Prasad T, Jyotsna RG, Reddy PK, Reddanna P. Hepatoprotective effects of Terminalia chebula fruit extract against 2-AAF-induced hepatic damage in Albino mice: role of MDR1 and COX-2. Journal of Herbs, Spices and Medicinal Plants. 2014; 20(4):402-20. https://doi.org/10.1080/10496475.2014.882283

Yeasmin T, Akhter QS, Siddika ST, Karim F. Effect of Terminalia chebula (Haritaki) on serum aspartate aminotransferase, alanine aminotransferase in paracetamol-induced liver damage in wister albino rats. Journal of Bangladesh Society of Physiologist. 2015; 10(1):1-5. https://doi.org/10.3329/jbsp.v10i1.24609

Choi MK, Kim HG, Han JM, Lee JS, Lee JS, Chung SH, Son CG. Hepatoprotective effect of Terminalia chebula against t‐BHP‐induced acute liver injury in C57/BL6 mice. Evidence‐Based Complementary and Alternative Medicine. 2015; (1):517350. https://doi.org/10.1155/2015/517350

Balakrishna V, Lakshmi T. Hepatoprotective activity of ethanolic extract of Terminalia chebula fruit against ethanol-induced hepatotoxicity in rats. Asian J Pharm Clin Res. 2017; 10(11):55-8. https://doi.org/10.22159/ajpcr.2017.v10i11.20270

Ahmadi-Naji R, Heidarian E, Ghatreh-Samani K. Evaluation of the effects of the hydroalcoholic extract of Terminalia chebula fruits on diazinon-induced liver toxicity and oxidative stress in rats. Avicenna Journal of Phytomedicine. 2017; 7(5):454.

Srilekha E, Desu BS. Hepatoprotective activity of ethanolic extract of Terminalia chebula fruits on ethanol-induced hepatotoxicity in Wistar rats.

Feng XH, Xu HY, Wang JY, Duan S, Wang YC, Ma CM. In vivo hepatoprotective activity and the underlying mechanism of chebulinic acid from Terminalia chebula fruit. Phytomedicine. 2021; 83:153479. https://doi.org/10.1016/j.phymed.2021.153479

Sarada S, Padmini E. Effect of gallic acid and Terminalia chebula on hepatic oxidative stress markers of high-fat diet-induced hyperlipidemic mice.