In Silico Screening of a Phytochemical Naringin, Isolated from Citrus decumana var. paradisi Against the Genes of Polycystic Ovary Syndromenes of Polycystic Ovary Syndrome

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Authors

  • Babita Rana
     Department of Botany, Guru Nanak Khalsa College, Matunga, Mumbai - 400019, Maharashtra ,IN
  • Merwyn Dcosta
     Department of Pharmaceutical Chemistry, Bombay College of Pharmacy, Mumbai - 400098, Maharashtra ,IN
  • Arvind Singh
     Department of Physics, Guru Nanak Khalsa College, Matunga, Mumbai - 400019, Maharashtra ,IN

DOI:

https://doi.org/10.18311/jnr/2024/36383

Keywords:

Citrus decumana var. paradisi, CYP 17, Hyperandrogenism, Molecular Docking, Polycystic Ovary Syndrome

Abstract

Polycystic Ovary Syndrome (PCOS) is a complex hormonal and metabolic disorder. The overproduction of androgens is the primary feature of PCOS. The currently available pharmacological agents recommended for the treatment of PCOS are linked with several adverse effects. Therefore, herbal-based drugs with lesser side effects, have become a favourable trend among people. A flavonoid glycoside, naringin isolated from different fruit parts of Citrus decumana var. paradisi (Macfad.) H.H.A. Nicholls exhibits a wide range of therapeutic properties. In the traditional system of medicine, it is used to improve ovarian health. To set down scientific evidence, molecular docking analysis was performed to find out the binding affinity of compound naringin with the protein CYP 17-cytochrome P 450, attributing to hyperandrogenism due to its overexpression, leading to PCOS. The docking score values were compared with the standard drug metformin to interpret the effectiveness of flavonoid naringin in the treatment of PCOS.

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Published

2024-04-18

How to Cite

Rana, B., Merwyn Dcosta, & Arvind Singh. (2024). <i>In Silico</i> Screening of a Phytochemical Naringin, Isolated from <i>Citrus decumana</i> var. <i>paradisi</i> Against the Genes of Polycystic Ovary Syndromenes of Polycystic Ovary Syndrome. Journal of Natural Remedies, 24(4), 897–903. https://doi.org/10.18311/jnr/2024/36383

Issue

Volume 24, Issue 4, April 2024

Section

Short Communication

Categories

License

Copyright (c) 2022 Babita Rana, Merwyn Dcosta, Arvind Singh (Author)

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

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Received 2024-01-28
Accepted 2024-02-29
Published 2024-04-18

 

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