Formulation Development and Evaluation of Film Liquid Bandage Using Gallic Acid for Wound Healing

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Authors

  • Sapna Desai
     Department of Pharmacology, Pioneer Pharmacy College, Ajwa Road, Vadodara - 390019, Gujarat ,IN
  • Snehal Patel
     Department of Pharmacy, Sumandeep Vidyapeeth, Vadodara - 391760, Gujarat ,IN
  • Himanshu Panchal
     Department of Pharmaceutical Chemistry, Parul Institute of Pharmacy, Parul University, Vadodara - 391760, Gujarat ,IN
  • Divyang Patel
     Department of Pharmacognosy, Institute of Pharmaceutical Sciences, Faculty of Pharmacy, Parul University, Vadodara - 391760, Gujarat ,IN
  • Jhanvi Sethi
     Department of Pharmacology, Pioneer Pharmacy College, Ajwa Road, Vadodara - 390019, Gujarat ,IN
  • Hardi Shah
     Department of Pharmacology, Pioneer Pharmacy College, Ajwa Road, Vadodara - 390019, Gujarat ,IN
  • Dhananjay Meshram
     Department of Pharmacology, Pioneer Pharmacy College, Ajwa Road, Vadodara - 390019, Gujarat ,IN

DOI:

https://doi.org/10.18311/jnr/2024/43800

Keywords:

Gallic Acid, In Vitro Skin Permeation, Liquid-Bandage, Retention Study and Wound Healing

Abstract

Background: Wound healing is a complex process requiring optimal tissue repair and regeneration conditions. Liquid bandages (L-bandages) offer an innovative approach to wound care by forming a protective film over wounds, aiding healing and preventing infections. Gallic Acid (GA), known for its anti-inflammatory, antibacterial, and antioxidant properties, is a promising natural agent for wound healing. Aim: This study aims to develop and evaluate a film-forming L- bandage incorporating GA for effective wound healing. Methods: Various formulations were prepared using film-forming agents such as xanthan gum, pectin gum and polyvinyl pyrrolidone, with GA as the active ingredient. The formulations were evaluated for physical properties, including pH, viscosity, drying time and film characteristics such as flexibility, washability, and stickiness. In vitro studies were conducted to assess skin permeation and drug retention. Results: The optimised formulation demonstrated desirable physical properties, including a pH of 5.6, appropriate viscosity and rapid drying time. The film was flexible, easily washable and exhibited minimal stickiness. In vitro permeation studies showed effective skin penetration and retention of GA, indicating its potential for sustained therapeutic action. Conclusion: The GA-based L- bandage showed promising results as a wound healing agent, offering a natural, effective solution for protecting and treating superficial skin injuries. The formulation’s favourable physical properties and drug delivery potential support its use as an innovative wound care product. Further studies are warranted to confirm its efficacy in clinical settings.

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Published

2024-11-06

How to Cite

Desai, S., Patel, S., Panchal, H., Patel, D., Sethi, J., Shah, H., & Meshram, D. (2024). Formulation Development and Evaluation of Film Liquid Bandage Using Gallic Acid for Wound Healing. Journal of Natural Remedies, 24(10), 2231–2241. https://doi.org/10.18311/jnr/2024/43800

Issue

Volume 24, Issue 10, October 2024

Section

Research Articles

License

Copyright (c) 2024 Sapna Desai, Snehal Patel, Himanshu Panchal, Divyang Patel, Jhanvi Sethi, Hardi Shah, Dhananjay Meshram (Author)

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

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Europe PMC
Received 2024-04-28
Accepted 2024-08-13
Published 2024-11-06

 

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