Effect of Avena sativa (Oats) on Spermatogenesis and Reproductive Health
Authors
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Department of Pharmacology, Vignan Pharmacy College, Vadlamudi, Guntur District, Andhra Pradesh ,IN
Vara Prasad Saka -
Department of pharmacology, K.V.S.R.Siddhartha College of Pharmaceutical sciences, Vijayawada, Andhra Pradesh ,INSiva Reddy Challa
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Department of Clinical Pharmacy and Pharmacology, Ibn Sina National College for Medical Studies ,INAkondi Butchi Raju
DOI:
https://doi.org/10.18311/jer/2016/15471Keywords:
Avena sativa(oats), Male Infertility, Spermatogeresis, Fluoride.Abstract
Infertility is a major problem of the day amongst men and women and marked by no pregnancy even after one year of unprotected intercourse. Almost 30% of infertility has been related with male factors, concerning sperm-low concentration, poor motility, decreased viability, and deformities. Factors like pollution, drugs, stress, life style changes, toxicants and nutritional deficiencies inflict deleterious effects on reproductive health, especially spermatogenesis. Fluoride is one such potent toxicant to which humans are exposed. The problem of fluorosis is known for long in India, especially in Andhra Pradesh. It was reported in several studies that fluoride interferes with the structural and functional integrity of the male reproductive system resulting in male factor infertility. Oat, Avena sativa, has a wide range of chemical and mineral constituents. The present research has been undertaken to evaluate the efficacy of oats as a nutrient and food supplement to lessen the fluoride-induced infertility in male rats. In this study fluoride, at a dose of 0.01 g/kg body weight, administered through oral route, induced infertility by causing damage to histoarchitecture of the testis and decrease in the levels of plasma testosterone, FSH, and LH. Treatment with hydroalcoholic extract of oats resulted in decreased damage to the reproductive organs and lesser impact on sperm parameters- sperm count, viability, morphology, motility, etc. Form the present study it is concluded that oats has the ability to decrease the toxic effect of fluoride.
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Sharma V, Boonen J, Spiegeleer BD, Dixit VK. Androgenic and spermatogenic activity of alkylamide-rich ethanol solution extract of Anacyclus pyrethrum DC. Phytother Res. 2013; 27(1):99–106. https://doi.org/10.1002/ptr.4697 PMid:22473789
Agarwal A, Allamaneni SSR. Oxidants and antioxidants in human fertility. Middle East Fertil Soc J. 2004; 9(3):187–97.
Yang WM, Kim HY, Park SY, Kim HM, Chang MS, Park SK. Cynomorium songaricum induces spermatogenesis with Glial Cell-Derived Neurotrophic Factor (GDNF) enhancement in rat testes. J Ethnopharmacol. 2010; 128(3):693–6.https://doi.org/10.1016/j.jep.2010.02.020 PMid:20219665
Mahdi AA, Shukla KK, Ahmad MK, Rajender S, Shankhwar SN, Singh V, Dalela D. Withania somnifera improves semen quality in stress-related male fertility.Evidence-Based Complement Altern Med. 2011; 9:1-8. https://doi.org/10.1093/ecam/nep138 PMid:19789214 PMCid:PMC3136684
Morakinyo AO, Achema PU, Adegoke O A. Effect of Zingiber officinale (Ginger) on sodium arsenite-induced reproductive toxicity in male rats. Afr J Biomed Res. 2010; 13:39–45.
Sarkar R, Mohanakumar KP, Chowdhury M. Effects of an organophosphate pesticide, quinalphos, on the hypothalamo-pituitary-gonadal axis in adult male rats. J Reprod Fertil. 2000; 118:29–38. https://doi.org/10.1530/ jrf.0.1180029 PMid:10793623
Chinoy N, Arti S. Amelioration of fluoride toxicity by vitamins E and D in reproductive functions of male mice. Fluoride. 1998; 31(4):203–16.
Sharma JD, Solanki D, Mamta S. Amelioration of fluoride toxicity in rats through vitamins (C, D) and calcium. Toxicol Int. 2013; 15(2):111–6.
Hu L, Ying J, Mu L, Yu S, Liang Z, Carole C. Fluoride toxicity in the male reproductive system. Fluoride. 2009; 42(4):260–76.
Krasowska A, Wlostowski T, Bonda E. Zinc protection from fluoride-induced testicular injury in the bank vole (Clethrionomys glareolus). Toxicol Lett. 2004; 147(3):229–35. https://doi.org/10.1016/j.toxlet.2003.11.012 PMid:15104114
El-Seweidy MM, Hashem RM, Abo-Elmathy DM, Mahamed RH. Frequent inadequate supply of micronutrients in fast food induces oxidative stress and inflammation in testicular tissues of weanling rats. J Pharm Pharmacol; 2008; 60(9):1237–43. https://doi.org/10.1211/jpp.60.9.0017 PMid:18718129
Nair N, Bedwal S, Prasad S, Saini MR, Bedwal RS. Shortterm zinc deficiency in diet induces increased oxidative stress in testes and epididymis of rats. Indian J Exp Biol. 2005; 43(9):786–94. PMid:16187529
Chatuevedi N, Sachdev Y, Shukla K. Diversified therapeutic potential of Avena sativa: An exhaustive review. Asian J Plant Sci Res. 2011; 1:103–14.
Ola SM, Mostafa MS, Zeinab YA, Hanan AA, Heba SM. Improving effect of dietary oat bran supplementation on oxidative stress induced by hyperlipidemic diet. Researcher. 2011; 3:1–10.
Rajinder S, Subrata De, Asma B. Avena sativa (Oat), a potential neutraceutical and therapeutic agent: An overview. Crit Rev Food Sci Nutr. 2013; 53:126–44. https://doi.org/10.1080/10408398.2010.526725 PMid:23072529
Emmons CL, David MP, Gregory LP. Antioxidant capacity of oat (Avena sativa L.) extracts. 2. In vitro antioxidant ac-tiv ity and contents of phenolic and tocol antioxidants. J Agric Food Chem. 1999; 47:4894–8. https://doi.org/10.1021/ jf990530i PMid:10606549
Kamran D, Sayed MA, Aram M. Effects of in vitro selenium addition to the semen extender on the spermatozoa characteristics before and after freezing in water buffaloes (Bubalus bubalis). Vet Res Forum. 2012; 3:263–8.
Abdella AM, Elabed BH, Bakhiet AO, Gadir WSA, Adam SEI. In vivo study on lead, cadmium and zinc supplementations on spermatogenesis in albino rats. J Pharmacol Technol. 201; 6(2):141–8.
Deepa K, Neena N, Ranveer SB. Effect of dietary zinc deficiency on testes of Wistar rats: Morphometric and cell quantification studies. J Trace Elem Med Biol. 2011; 25:47–53. https://doi.org/10.1016/j.jtemb.2010.11.002 PMid:21145718
Sí¸rensen MB, Bergdahl IA, Hjí¸llund NHI, Bonde JPE, Stoltenberg M, Ernst E. Zinc, magnesium and calcium in human seminal fluid: Relations to other semen parameters and fertility. Mol Hum Reprod. 1999; 5:331–7. https://doi.org/10.1093/molehr/5.4.331 PMid:10321804
Croxford TP, McCormick NH, Kelleher SL. Moderate zinc deficiency reduces testicular Zip 6 and Zip 10 abundance and impairs spermatogenesis in mice. J Nutr. 2011 Mar; 141(3):359–65. https://doi.org/10.3945/jn.110.131318 PMid:21248196 PMCid:PMC3040901
Tuncer I, Sunar F, Toy H, Baltaci AK, Mogulkoc R. Histological effects of zinc and melatonin on rat testes. Bratisl Lek Listy. 2011; 112:425–7.
Yunsang C, Yang W. Functions of essential nutrition for high quality spermatogenesis. Adv Biosci Biotechnol. 2011; 2:182–97. https://doi.org/10.4236/abb.2011.24029
Ronald GT. Method for producing oat extract. United States Patent; 1995. 5468491.
Chinoy NJ, Shruti S, Amita SW, Bhattacharya S. Fluoride toxicity on rat testis and cauda epididymal tissue components and its reversal. Fluoride. 1997; 30:41–50.
Chauhan NS, Dixit VK. Spermatogenic activity of rhizomes of Orchioides gaertnin male rats. Int J Appl Res Nat Prod. 2008; 1:26–31.
Nassiri M, Khaki A, Ahmadi-Ashtiani HR, Rezazadeh SH, Rastgar H, Gharachurlu SH. Effects of ginger on spermatogenesis in streptozotocin-induced diabetic rat. J Med Plants. 2009; 8:1–7.
Godson GA, Oluwaseyi SO, Chia LS, Babatunde O, Ayomide JB, Emmanuel OS. Ameliorative effect of Moringa oleifera (drumstick) leaf extracts on chromium-induced testicular toxicity in rat testes. World J Life Sci Med Res. 2012; 2:20–26.
Rahul BP, Shreya RV, Meena MP. Protective effect of spermatogenic activity of Withania somnifera (Ashwagandha) in galactose-stressed mice. Ann Biol Res. 2012; 3:4159–65.
Sethi S, Chaturvedi CM. Temporal synergism of neurotransmitters (serotonin and dopamine) affects testicular development in mice. Zoology. 2009; 112:461–70. https:// doi.org/10.1016/j.zool.2009.03.002 PMid:19765962
Rahul BP, Shreya RV, Meena MP. Spermatogenic activity of dietary antioxidant in oxidatively stressed mice. J Cell Tissue Res. 2008; 8:1519–24.
Ibukun PO, RajiY, Benjamin OE, Adeyombo FB. Effects of nicotine on sperm characteristics and fertility profile in adult male rats: A possible role of cessation. J Reprod Infertil. 2011; 12:201–7.
Khaki A, Fathiazad F, Nouri M, Khaki AA, Khamenehi HJ, Hamadeh M. Evaluation of androgenic activity of Allium cepa on spermatogenesis in the rat. Folia Morphol. 2009; 68:45–51.
Bataineh HN, Nusier MK. Impact of 12-week ingestion of sodium fluoride on aggression, sexual behavior, and fertility in adult male rats. Fluoride. 2006; 39:293–301.
Ahmed E, Homa D, Ahmad SAH. Fertility effects of sodium fluoride in male mice. Fluoride. 2000; 33:128–34.
Chinoy NJ, Mehta D, Jhala DD. Effects of fluoride ingestion with protein-deficient or protein-enriched diets on sperm function of mice. Fluoride. 2006; 39:11–16.
Messer HH, Armstrong WD, Singer L. Influence of fluoride uptake on reproduction in mice. J Nutr. 1976; 106:1115–22.
De Lamirande E, Gagnon C. Impact of reactive oxygen species on spermatozoa: A balancing act between beneficial and detrimental effects. Hum Reprod. 1995; 1:15–21.https://doi.org/10.1093/humrep/10.suppl_1.15
Chinoy NJ, Mehta D, Jhala DD. Effects of fluoride on physiology of some animals and human beings. Indian J Environ Toxicol. 1991; 1:17–32.
Chinoy NF, Narayana MV, Dalal V, Rawat M, Patel D.Amelioration of fluoride toxicity in some accessory reproductive glands and spermatozoa of rat. Fluoride. 1995; 28:75–86.
Kumar A, Susheela AK. Ultrastructural studies of spermiogenesis in rabbit exposed to chronic fluoride toxicity. Int J Fertil Monopausal Stud. 1994; 39:164–71.PMid:7920753
Shashi A. Histopathological changes in rabbit testis during experimental fluorosis. Folia Morphol. 1990; 38:63–5.
Chinoy NJ, Narayana MV, Sequeira E, Joshi SM, Barot JM, Purohit RM. Studies on effects of fluoride in 36 villages of Mehsana District, North Gujarat. Fluoride. 1992; 25:101–10.
Ortiz-Perez D, Rodriguez-Martinez M, Martinez F, BorjaAburto VH, Castelo J, Grimaldo JI. Fluoride-induced disruption of reproductive hormones in men. Environ Res. 2003; 93:20–30. https://doi.org/10.1016/S00139351(03)00059-8
Tokar VI, Savchenko ON. Effect of inorganic fluorine compounds on the functional state of the pituitary-testis system. Probl Endokrinol (Mosk). 1977; 23:104–7.
El-Seweidy MM, Hashem RM, Abo-Elmathy DM, Mahamed RH. Frequent inadequate supply of micronutrients in fast food induces oxidative stress and inflammation in testicular tissues of weanling rats. J Pharm Pharmacol. 2008; 60:1237– 43. https://doi.org/10.1211/jpp.60.9.0017 PMid:18718129
Wan S, Zhang J, Wang J. Effect of high fluoride on sperm quality and testicular histology in male rats. Fluoride. 2006; 39:17–21.
Chabre M, Aluminofluoride and beryllium fluoride complexes: A new phosphate analog in enzymology. Trends Biochem Sci. 1990; 15:17–21. https://doi.org/10.1016/0968-0004(90)90117-T
Krasowska A, Wlostowski T. Photoperiodic elevation of testicular zinc protects seminiferous tubules against fluoride toxicity in the bank vole (Clethrionomys glareolus). Comp Biochem Physiol. C Pharmacol Toxicol Endocrinol. 1996; 113:81–4. https://doi.org/10.1016/0742-8413(95)02049-7
Krasowska A, Wlostowski T, Bonda E. Zinc protection from fluoride-induced testicular injury in the bank vole (Clethrionomys glareolus). Toxicol Lett. 2004; 147:229–35. https://doi.org/10.1016/j.toxlet.2003.11.012 PMid:15104114
Oteiza PL, Olin KL, Fraga CG, Keen CL. Oxidant defense systems in testes from zinc deficient rats. Proc Soc Exp Biol Med. 1996; 213:85–91. https://doi.org/10.3181/00379727213-44040 PMid:8820828
Zakrzewska H, Udala J, Blaszczyk B. In vitro influence of sodium fluoride on ram semen quality and enzyme activities.Fluoride. 2002; 35:153–60.
Singh PK, Feroz AD, Sheeba H, Khalil A, Samir AM. Beneficial effect of Tamarindus indica on the testes of albino rat after fluoride intoxication. Int J Pharmacol Bio Sci. 2012; 3:487–93.
Hidiroglou M, Knipfel JE. Zinc in mammalian sperm. J Dairy Sci. 1984; 67:1147–56. https://doi.org/10.3168/jds.S0022-0302(84)81416-2
Mason KE, Burns WA, Smith Jr. Testicular damage associated with zinc deficiency in pre- and post-pubertal rats: Response to zinc repletion. J Nutr. 1982; 112:1019–28.https://doi.org/10.1093/jn/112.5.1019 PMid:7077414
Wang S, Wang G, Barton BE, Murphy TF, Huang HF.Beneficial effects of vitamin E in sperm functions in the rat after spinal cord injury. J Androl. 2007; 28(2):334–41.ht t p s : / / d o i . o r g / 1 0 . 2 1 6 4 / j and rol . 1 0 6 . 0 0 1 1 6 4 PMid:17079740
Bratt K, Sunnerheim K, Bryngelsson S, Fagerlund A, Engman L, Andersson RE, Dimberg LH. Avenanthramides in oats (Avena sativa L.) and structure-antioxidant activity relationship. J Agric Food Chem. 2003; 51(3):594–600.https://doi.org/10.1021/jf020544f PMid:12537428
Xu JG, Tian CR, Hu QP, Luo JY, Wang XD, Tian XD.Dynamic changes in phenolic compounds and antioxidant activity in oats (Avena nuda L.) during steeping and germination.J Agric Food Chem. 2009; 57(21):10392–8. https:// doi.org/10.1021/jf902778j PMid:19827789
