Influence Ovariectomy on Parathyroid Gland Function in Local Bitches

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Authors

  • Ali Habeeb Jaber AL-bdeery
     Department of Surgery and Obstetrics, College of Veterinary Medicine, Al-Qadisiyah University, Al-Diwaniyah ,IQ
  • Basim Hameed Abed Ali
     Department of Surgery and Obstetrics, College of Veterinary Medicine, Al-Qadisiyah University, Al-Diwaniyah ,IQ
  • Alaa Kamil Abdulla
     Department of Medical Biotechnology, College of Biotechnology, Al-Qadisiyah University, Al-Diwaniyah ,IQ
  • Hassan Al-Karagoly
     Department of Internal Medicine, College of Veterinary Medicine, Al-Qadisiyah University, Al-Diwaniyah ,IQ

DOI:

https://doi.org/10.18311/jer/2018/23613

Keywords:

Local Bitches, Parathyroid Gland, Ovariectomy
Obstetrics

Abstract

Background and Aims: The present study was conducted to assess the effect of ovarian function on the parathyroid gland in local breed bitches in the center of Al-Diwaniyah city, Iran. Materials and Methods: The experiment was carried out on 21 local breed female bitches aged 18 to 30 months housed in the small animal housing of the College of Veterinary Medicine. The animals were divided into three groups of seven each: G1, animals in estrus phase, G2, animals in anestrus phase, and G3, the ovariectomized group. After expressed consent of the owners, ovariectomy was performed immediately after anesthetization. Blood samples were collected to analyze the levels of estrogen, PTH, calcitonin, serum calcium, ionized calcium and 1,25-dihydroxyvitamin D3. Results: Our results in respect of estrogen and PTH revealed a significant effect in G3 and G2 groups as compared with G1 group at p<0.01. The concentration of calcitonin recorded insignificant decrease in G3, 5.35 pg/mL, when compared with G1 which was 6.98 pg/mL. The lowest serum calcium level was recorded in group G3, 8.29 mg/dL, and highest in the group G1, 11.21 mg/dL. The lowest concentration of 1,25-dihydroxyvitamin D3 was found in G3, 18.24 mg/dL, while the highest concentration was 39.56 mg/dL found in group G1. Conclusion: We conclude that decrease of estrogen levels leads to low calcium level, and then increase in the level of PTH in the blood. High level of calcium in the blood leads to increased secretion of calcitonin hormone from the thyroid gland, and calcitonin has no significant effect on the calcium regulation under normal conditions. A decrease in estrogen level leads to a low concentration of 1,25-dihydroxyvitamin D3 followed by decrease of the concentration of ionized calcium.

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Published

2020-09-02

How to Cite

AL-bdeery, A. H. J., Hameed Abed Ali, B., Kamil Abdulla, A., & Al-Karagoly, H. (2020). Influence Ovariectomy on Parathyroid Gland Function in Local Bitches. Journal of Endocrinology and Reproduction, 22(2), 13–17. https://doi.org/10.18311/jer/2018/23613

Issue

Volume 22, Issue 2, December 2018

Section

Original Research
Crossref
Scopus
Google Scholar
Europe PMC

 

References

Bishop GT, Evans BA, Kyle KL, Kogan LR. Owner satisfaction with use of videoconferencing for recheck examinations following routine surgical sterilization in dogs. J Am Veter Med Assoc. 2018;253(9):1151–57.

Zwida K, Kutzler MA. Non-reproductive long-term health complications of gonad removal in dogs as well as possible causal relationships with post-gonadectomy elevated Luteinizing Hormone (LH) concentrations. J Etiol Anim Health. 2016;1(1):1–11.

Hughes J, Macdonald DW. A review of the interactions between free-roaming domestic dogs and wildlife. Biol Conserv. 2013;157:341–351.

Du Z, Xiao Y, Hashimi S, Hamlet SM, Ivanovski S. The effects of implant topography on osseointegration under estrogen deficiency induced osteoporotic conditions: Histomorphometric, transcriptional and ultrastructural analysis. Acta Biomat. 2016;42:351–63.

van Abel M, Hoenderop JG, Dardenne O, et al. 1,25-Dihydroxyvitamin D3-independent stimulatory effect of estrogen on the expression of ECaC1 in the kidney. J Am Soc Nephrol. 2002;13(8):2102–9.

Tao Z-S, Qiang Z, Tu K-k, et al. Treatment study of distal femur for parathyroid hormone (1–34) and β-tricalcium phosphate on bone formation in critical size defects in rats. J Biomat Appl. 2015;30(4):484–91.

Squires EJ. Appl AnimEndocrinol: Cabi; 2010.

Kumar R, Thompson JR. The regulation of parathyroid hormone secretion and synthesis. J Amer Soc Nephrol. 2011;22(2):216–24.

Felsenfeld AJ, Levine BS. Calcitonin, the forgotten hormone: does it deserve to be forgotten? Clin Kidney J. 2015;8(2):180–7.

Parker V, Harjes L, Dembek K, Young G, Chew D, Toribio R. Association of vitamin D metabolites with parathyroid hormone, fibroblast growth factor"23, calcium, and phosphorus in dogs with various stages of chronic kidney disease. J Veter Intern Med. 2017;31(3):791–98.

Spoo J, Downey R, Griffitts C, et al. Plasma vitamin D metabolites and C"reactive protein in stage"stop racing endurance sled dogs. J Veter Inter Med. 2015;29(2):519–25.

Shieh A, Chun RF, Ma C, et al. Effects of high-dose vitamin D2 versus D3 on total and free 25-hydroxyvitamin D and markers of calcium balance. J Clin Endocrinol Metab. 2016;101(8):3070–78.

Massart A, Debelle FD, Racapé J, et al. Biochemical parameters after cholecalciferol repletion in hemodialysis: results from the VitaDial randomized trial. Am J Kidney dis. 2014;64(5):696–705.

Hollis BW, Wagner CL. The role of the parent compound vitamin D with respect to metabolism and function: why clinical dose intervals can affect clinical outcomes. J Clin Endocrinol Metab. 2013;98(12):4619–28.

Blaine J, Chonchol M, Levi M. Renal control of calcium, phosphate, and magnesium homeostasis. Clin J Amer Soc Nephrol. 2015;10(7):1257–72.

Serafim M, Duarte A, Silva G, et al. Impact of growth hormone (GH) and follicle stimulating hormone (FSH) on in vitro canine preantral follicle development and estradiol production. Growth Hormone & IGF Res. 2015;25(2):85–9.

Rodas-Ruiz J, Tabares-Serna C, Giraldo-Echeverri C. Evaluation of prostaglandin F2α, estradiol benzoate and deslorelin acetate protocol for oestrus induction in bitches. Arc Med Veter. 2015;47(3):395–99.

Axnér E, Holst BS. Concentrations of anti-Müllerian hormone in the domestic cat. Relation with spay or neuter status and serum estradiol. Theriogenology. 2015;83(5):817–21.

Laganí A, Vitale S, Ban Frangež H, et al. Vitamin D in human reproduction: the more, the better? An evidencebased critical appraisal. Eur Rev Med Pharmacol Sci. 2017;21(18):4243–51.

de Barboza GD, Guizzardi S, de Talamoni NT. Molecular aspects of intestinal calcium absorption. World J Gastroenterol. 2015;21(23):7142–54.

Rastogi S. Essentials of Animal Physiology: New Age International; 2007.

Rathod A, Bonny O, Guessous I, et al. Association of urinary calcium excretion with serum calcium and vitamin D levels. Clin J Am Soc Nephrol. 2015;10(3):452–62.

Saleh F, Jorde R, Svartberg J, Sundsfjord J. The relationship between blood pressure and serum parathyroid hormone with special reference to urinary calcium excretion: the Tromsí¸ study. J Endocrinol Invest. 2006;29(3):214–20.

Talmage R, Lester G, Hirsch P, Musculoske J. Parathyroid hormone and plasma calcium control: an editorial. J Musculoskel Neuron Interact. 2000;1:121–6.

Qureshi HJ, Hussain G, Jafary ZA, Bashir MU, Latif N, Riaz Z. Calcium status in premenopausal and postmenopausal women. J Ayub Med CollAbbottabad. 2010;22(2):143–5.

Thomas J, Lerche P. Anesthesia and Analgesia for Veterinary Technicians: Elsevier Health Sciences; 2016.

Pallant J, Manual SS. A step by step guide to data analysis using SPSS for windows version 15. SPSS Survival Manual. 2007;3.

Mandigers P, Nell T. Treatment of bitches with acquired urinary incontinence with oestriol. Veterinary record. 2001;149(25):764–7.

Carrillo-López N, Román-Garcí­a P, Rodrí­guez-Rebollar A, et al. . Indirect regulation of PTH by estrogens may require FGF23. J Am Soc Nephrol. 2009;20(9):2009–17.

Miller WL, Portale AA. Vitamin D 1α-hydroxylase. Trends in Endocrinology & Metabolism. 2000;11(8):315–9.

St-Arnaud R, Glorieux F. Hereditary defects in vitamin D metabolism and action. Endocrinology. 2000;2:1154–68.

Dardenne O, Prud'homme Je, Arabian A, et al. Targeted inactivation of the 25-hydroxyvitamin D3-1α-hydroxylase gene (CYP27B1) creates an animal model of pseudovitamin D-deficiency rickets. Endocrinology. 2001;142(7): 3135–41.

Prosser DE, Jones G. Enzymes involved in the activation and inactivation of vitamin D. Trends in biochemical sciences. 2004;29(12):664–73.

Noakes DE, Parkinson TJ, England GC. Veterinary Reproduction & Obstetrics: Elsevier Health Sciences; 2018.

Silverman SL. Calcitonin. Endocrinology and Metabolism Clinics of North America. 2003;32(1):273–84.

Bell TD, Demay MB, Burnett"Bowie SAM. The biology and pathology of vitamin D control in bone. J Cell Biochem. 2010;111(1):7–13.

Somjen D, Katzburg S, Sharon O, et al. Mutual modulation of femarelle and vitamin D analog activities in human derived female cultured osteoblasts. Cogent Biol. 2017;3(1):1374919.

Nair P, Lee P, Reynolds C, et al. Significant perturbation of vitamin D–parathyroid–calcium axis and adverse clinical outcomes in critically ill patients. Inte care Medicine. 2013;39(2):267–74.

Wyon MA, Wolman R, Nevill AM, et al. The influence of hormonal contraception on vitamin D supplementation on serum 25(OH)D3 status in premenopausal women: A prospective double-blind placebo random controlled trial. J Endocrinol Metab. 2017;7(4):117–21.