Female Fertility Clock Closes to Tick around the Age of 43

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Authors

  • Baidyanath Chakravarty
     Department of Assisted Reproduction, Institute of Reproductive Medicine, HB-36/A/3, Sector -III, Salt Lake City, Kolkata − 700064, West Bengal ,IN
  • Ratna Chattopadhyay
     Department of Assisted Reproduction, Institute of Reproductive Medicine, HB-36/A/3, Sector -III, Salt Lake City, Kolkata − 700064, West Bengal ,IN
  • Kuladip Jana
     Division of Molecular Medicines, Bose Institute (Centenary Building), P 1/12, C. I. T. Road, Scheme-VIIM, Kolkata − 700054, West Bengal ,IN
  • Pratip Chakraborty
     Department of Assisted Reproduction, Institute of Reproductive Medicine, HB-36/A/3, Sector -III, Salt Lake City, Kolkata − 700064, West Bengal ,IN

DOI:

https://doi.org/10.18311/jer/2021/27816

Keywords:

Age, Live Birth Rate, Ovarian Function
in vitro fertilization outcome

Abstract

Objective: To investigate if attempting In Vitro Fertilization (IVF) in women over 40 is of worth. Materials & Methods: Two hundred and thirty nine women over 40 years of age undergoing IVF were enrolled. Long protocol was used for downregulation followed by stimulation and IVF-ET. The primary outcome measure was live-birth rate. Secondary outcomes included rates of miscarriage, cycle cancellation, obstetrical complications, and maternal and fetal adverse events. Results: Clinical pregnancy rates per cycle were 42.85 %, 39.34 %, 34.09 %, 27.27 % and 16.66 % for 40, 41, 42, 43 and 44 years old, respectively. Absolute difference in live birth rate in age 40 - 44 vs control, -15 percentage points; 95 % Confidence Interval (CI) -45 to 15.1, -18.77 percentage points; 95 % CI,(-56.31 to 18.79), -23.77 percentage points; 95 % CI,(-71.31 to 23.81), -25.82 percentage points; 95 % CI, (-77.48 to 25.84) and, - 27.72 percentage points; 95 % CI, (-83.16 to 27.76), respectively. Intra-uterine growth restriction and preterm delivery occurred significantly more frequently in the age group of 42 and above. Only one IVF cycle in patients aged 44 resulted in delivery. Conclusion: It appears that IVF treatment should be limited to patients not older than 43 years, with adequate ovarian response.

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Published

2021-07-20

How to Cite

Chakravarty, B., Chattopadhyay, R., Jana, K., & Chakraborty, P. (2021). Female Fertility Clock Closes to Tick around the Age of 43. Journal of Endocrinology and Reproduction, 25(1), 79–85. https://doi.org/10.18311/jer/2021/27816

Issue

Volume 25, Issue 1, June 2021

Section

Original Research
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Europe PMC

 

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