Pancreatic β-Cell Dysfunction in Diabetes
Authors
-
The Jackson Laboratory, Bar Harbor, 04609, Maine ,US
Ansarullah -
School of Science, Navrachana University, Vadodara 391410, Gujarat ,INA. V. Ramachandran
DOI:
https://doi.org/10.18311/jer/2022/32055Keywords:
β-Cell Dedifferentiation, β-Cell Dysfunction, β-Cell IdentityAbstract
The decline in functional β-cell mass and β-cell dysfunction causes diabetes. Pancreatic β-cells play a fundamental role in controlling the glucose milieu, and β-cells of diabetic patients poorly respond to glucose. The mechanism underlying the pathology of impaired β-cell function is a unique challenge. This concise review summarizes the identity of β-cells during the progression and established diabetes. Understanding β-cell heterogeneity and the dynamic functional state during health and disease progression would be important for designing diabetes therapeutics to restore the β-cell mass by cellreplacement or regeneration approaches.
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