Histopathological and Immunohistochemical Analysis of Ruptured Tubal Ectopic Pregnancy

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Authors

  • Priya Aarthy Archunan
     Department of Obstetrics and Gynaecology, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 602105, Tamil Nadu ,IN
  • Anuradha Monga
     Department of Obstetrics and Gynaecology, Ravindra Nath Tagore Medical College, Udaipur - 313001, Rajasthan ,IN
  • Sangeeta Sen
     Department of Obstetrics and Gynaecology, Ravindra Nath Tagore Medical College, Udaipur - 313001, Rajasthan ,IN
  • Bavani Narayana Moorthy
     Department of Animal Science, Bharathidasan University, Tiruchirappalli - 620024, Tamil Nadu ,IN
  • Silambarasan Velliyangiri
     Department of Animal Science, Bharathidasan University, Tiruchirappalli - 620024, Tamil Nadu ,IN
  • Deepalakshmi Govindarajan
     Department of Animal Science, Bharathidasan University, Tiruchirappalli - 620024, Tamil Nadu ,IN
  • Akbarsha Mohammad Abdulkader
     Department of Biotechnology and Microbiology, National College (Autonomous), Tiruchirappalli - 620024, Tamil Nadu ,IN
  • Archunan Govindaraju
     Department of Animal Science, Bharathidasan University, Tiruchirappalli - 620024, Tamil Nadu ,IN

DOI:

https://doi.org/10.18311/jer/2023/33678

Keywords:

Bcl2, Desmin, Ectopic Pregnancy, Histology, Tubal Rupture

Abstract

Ectopic Pregnancy (EP) is reported to be causative of high incidence of maternal death and morbidity. It must be diagnosed during the first trimester immediately after symptoms of severe bleeding, abdominal pain, and cramping. Ultrasonography is the only possible detection method to confirm EP. Patients are at greater risk of EP due to inefficient early detection methods. An early detection of the EP based on cellular markers would possibly improve the diagnosis and clinical management. Therefore, an attempt was made to study the histoarchitecture of, and to identify the biomarkers in, the fallopian tube during rupture of ectopic pregnancy. Histological analysis revealed the formation of hematosalpinx and hydrosalpinx in the fallopian tube. Further, immunohistochemical study of the fallopian tissue of EP patients showed remarkable evidence of protein markers such as Bcl2 and desmin which may be considered as potential cellular markers for the detection of EP.

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Published

2024-01-04

How to Cite

Archunan, P. A., Monga, A., Sen, S., Moorthy, B. N., Velliyangiri, S., Govindarajan, D., Abdulkader, A. M., & Govindaraju, A. (2024). Histopathological and Immunohistochemical Analysis of Ruptured Tubal Ectopic Pregnancy. Journal of Endocrinology and Reproduction, 27(4), 253–260. https://doi.org/10.18311/jer/2023/33678

Issue

Volume 27, Issue 4, December 2023

Section

Research Article
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Europe PMC

 

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