5α-Reductase Inhibitory Potential of Hibiscus rosa sinensis: Effective for the Management of Alopecia

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Authors

  • Arpan Chakraborty
     Department of Pharmaceutical Technology, Maulana Abul Kalam Azad University of Technology, Nadia, West Bengal - 741249 ,IN
  • Arka Bhattacharjee
     Department of Pharmaceutical Technology, Maulana Abul Kalam Azad University of Technology, Nadia, West Bengal - 741249 ,IN
  • Baishakhi Mondal
     Department of Pharmaceutical Technology, Maulana Abul Kalam Azad University of Technology, Nadia, West Bengal - 741249 ,IN
  • Manas Chakraborty
     Department of Pharmaceutical Technology, Calcutta Institute of Pharmaceutical Technology and Allied Health Sciences, Howrah, West Bengal - 711 316 ,IN
  • Goutam Mukhopadhyay
     Department of Pharmaceutical Technology, BCDA College of Pharmacy and Technology (Campus 2), Kolkata, West Bengal - 700129 ,IN
  • Alpana Majumder
     Department of Kayachikitsa, Institute of Post Graduate Ayurvedic Education and Research, Kolkata, West Bengal - 700009 ,IN

DOI:

https://doi.org/10.18311/jnr/2023/31180

Keywords:

Alopecia, Hair Loss, Hibiscus rosa sinensis, NADPH, Quercetin, 5α-Reductase

Abstract

The condition known as male pattern hair loss and benign prostatic hyperplasia are both treated with a family of drugs known as 5 alpha reductase (5α-reductase) inhibitors. This study shows that the flower of Hibiscus rosa sinensis has 5α-reductase inhibitory action that is helpful in the treatment of androgenic diseases. Phytochemical screening was done using petroleum ether, methanol, and water extracts to identify the phytochemical group present. Then, using quercetin as a reference flavonoid component, the Total Flavonoid Content (TFC) was assessed using a colorimetric technique. The 5α-reductase inhibitory activity was evaluated using several extracts and compared to the well-known 5α-reductase inhibitor finasteride. Finally, the inhibition of different extracts to the enzyme was assessed using a biochemical approach to measure the activity of 5α-reductase. It was determined that the IC<sub>50</sub> value of Hibiscus rosa sinensis methanolic extract, 146.048 ± 0.453 (μg/mL) and quercetin (a chemical biomarker of the plant material) 141.426 ± 1.578 (μg/mL), were promising candidates for future investigation into their antiandrogenic activities.

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Published

2023-06-13

How to Cite

Chakraborty, A., Bhattacharjee, A., Mondal, B., Chakraborty, M., Mukhopadhyay, G., & Majumder, A. (2023). 5α-Reductase Inhibitory Potential of <i>Hibiscus rosa sinensis</i>: Effective for the Management of Alopecia. Journal of Natural Remedies, 23(2), 467–474. https://doi.org/10.18311/jnr/2023/31180

Issue

Volume 23, Issue 2, April 2023

Section

Research Articles

License

Copyright (c) 2023 ARPAN CHAKRABORTY, Arka Bhattacharjee, Baishakhi Mondal, Manas Chakraborty, Goutam Mukhopadhyay

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

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Europe PMC
Received 2022-09-02
Accepted 2023-04-24
Published 2023-06-13

 

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