Potential Remedial Effects of Solanum nigrum Berries on Alopecia: An In Vivo Study

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Authors

  • Arpan Chakraborty
     Department of Pharmaceutical Technology, Maulana Abul Kalam Azad University of Technology, Nadia – 741249, West Bengal ,IN
  • Arka Bhattacharjee
     Department of Pharmaceutical Technology, Maulana Abul Kalam Azad University of Technology, Nadia – 741249, West Bengal ,IN
  • Manas Chakraborty
     Department of Pharmaceutical Technology, Calcutta Institute of Pharmaceutical Technology and Allied Health Sciences, Howrah – 711316, West Bengal ,IN
  • Goutam Mukhopadhyay
     Department of Pharmaceutical Technology, BCDA College of Pharmacy and Technology (Campus – 2), Kolkata – 700129, West Bengal ,IN
  • Baishakhi Mondal
     Department of Pharmaceutical Technology, Maulana Abul Kalam Azad University of Technology, Nadia – 741249, West Bengal ,IN
  • Alpana Majumder
     Department of Kayachikitsa, Institute of Post Graduate Ayurvedic Education and Research, Kolkata – 700009, West Bengal ,IN
  • Mainak Chakraborty
     Department of Pharmaceutical Technology, NSHM Knowledge Campus, Kolkata – 700129, West Bengal ,IN
  • Nilanjan Sarkar
     Department of Pharmaceutical Technology, NSHM Knowledge Campus, Kolkata – 700129, West Bengal ,IN

DOI:

https://doi.org/10.18311/jnr/2024/34626

Keywords:

Alopecia, HPLC, In Vivo, Solanum nigrum, TLC

Abstract

This study aimed to explore the ability of Solanum nigrum (S. nigrum) to stimulate hair growth. In this study, we investigated the effectiveness of two different extracts named methanol and petroleum ether from S. nigrum when applied topically. Hair loss was induced in Swiss albino rats by subcutaneously administering testosterone for 21 days. The extract was applied at the same time to assess its ability to prevent hair loss, and various measures such as follicle density, anagen/telogen (A/T) ratio, and skin section histology were monitored. Finasteride solution was used as a standard for topical application. The group treated with petroleum ether extract of S. nigrum showed noticeable hair regrowth, evidenced by increased (A/T) ratio, follicle density, and positive results in skin sections. The study’s findings suggest that the petroleum ether extract derived from S. nigrum shows potential in treating hair loss induced by testosterone in experimental animals.

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Published

2024-01-01

How to Cite

Chakraborty, A., Bhattacharjee, A., Chakraborty, M., Mukhopadhyay, G., Mondal, B., Majumder, A., Chakraborty, M., & Sarkar, N. (2024). Potential Remedial Effects of <i>Solanum nigrum</i> Berries on Alopecia: An <i>In Vivo</i> Study. Journal of Natural Remedies, 24(1), 117–126. https://doi.org/10.18311/jnr/2024/34626

Issue

Volume 24, Issue 1, January 2024

Section

Research Articles

License

Copyright (c) 2023 Arpan Chakraborty, Arka Bhattacharjee, Manas Chakraborty, Goutam Mukhopadhyay, Baishakhi Mondal, Alpana Majumder, Mainak Chakraborty, Nilanjan Sarkar (Author)

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

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Received 2023-08-02
Accepted 2023-10-12
Published 2024-01-01

 

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