Formulation and Evaluation of Herbal Excipients-Based Ketoconazole Cream for Fungal Infection

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Authors

  • Janki B. Patel
     Faculty of Pharmacy, Department of Pharmaceutics, Parul Institute of Pharmacy and Research, Parul University, Vadodara – 391760, Gujarat ,IN
  • Mansi Gajera
     Faculty of Pharmacy, Department of Pharmaceutics, Parul Institute of Pharmacy and Research, Parul University, Vadodara – 391760, Gujarat ,IN
  • Zalak Shah
     Faculty of Pharmacy, Department of Pharmaceutics, Parul Institute of Pharmacy and Research, Parul University, Vadodara – 391760, Gujarat ,IN
  • Pinkal Patel
     Faculty of Pharmacy, Department of Pharmaceutics, Parul Institute of Pharmacy and Research, Parul University, Vadodara – 391760, Gujarat ,IN
  • Kinjal Parmar
     Faculty of Pharmacy, Department of Pharmaceutics, Parul Institute of Pharmacy and Research, Parul University, Vadodara – 391760, Gujarat ,IN
  • Vaishali Patel
     Faculty of Pharmacy, Department of Pharmaceutics, Parul Institute of Pharmacy and Research, Parul University, Vadodara – 391760, Gujarat ,IN
  • Hetvi Patel
     Faculty of Pharmacy, Department of Pharmaceutics, Parul Institute of Pharmacy and Research, Parul University, Vadodara – 391760, Gujarat ,IN
  • Disha Patel
     Faculty of Pharmacy, Department of Pharmaceutics, Parul Institute of Pharmacy and Research, Parul University, Vadodara – 391760, Gujarat ,IN
  • Kanupriya Rathore
     Faculty of Pharmacy, Department of Pharmaceutics, Parul Institute of Pharmacy and Research, Parul University, Vadodara – 391760, Gujarat ,IN

DOI:

https://doi.org/10.18311/jnr/2023/32329

Keywords:

Anti-Fungal Activity, Cream Formulation, Coconut Oil, Herbal Excipients, Ketoconazole, Shea Butter

Abstract

The goals of the current studies were to create herbal excipients-based ketoconazole cream to enhance the efficacy against chronic mucocutaneous candidiasis. Ketoconazole, coconut oil and other herbal excipients namely shea butter, bees wax, Lanolin and Rose oil were used for the formulation. Each formulation was prepared with various concentrations of coconut oil. Every prepared formulations were evaluated successfully. Among all the formulations F4 was the best that exhibiting a higher in vitro diffusion rate 59.6 ± 0.10 % CDR within 480 min with maximum antifungal efficacy, compared with the marketed formulation. We might therefore say that herbal excipients-based cream improved patient compliance and is a superior alternative to oral preparation, easier administration, local bioavailability, and better results for individuals with persistent mucocutaneous candidiasis who are afflicted with fungi.

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Published

2023-06-13

How to Cite

Patel, J. B., Gajera, M., Shah, Z., Patel, P., Parmar, K., Patel, V., Patel, H., Patel, D., & Rathore, K. (2023). Formulation and Evaluation of Herbal Excipients-Based Ketoconazole Cream for Fungal Infection. Journal of Natural Remedies, 23(2), 583–592. https://doi.org/10.18311/jnr/2023/32329

Issue

Volume 23, Issue 2, April 2023

Section

Research Articles

License

Copyright (c) 2023 Janki B. Patel, Mansi Gajera, Zalak Shah, Pinkal Patel, Kinjal Parmar, Vaishali Patel, Hetvi Patel, Disha Patel, Kanupriya Rathore (Author)

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

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Europe PMC
Received 2023-01-07
Accepted 2023-04-20
Published 2023-06-13

 

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