In Silico Screening of Phytochemicals as an Approach against Tubulin Inhibitor in Prostate Cancer

Abstract

Background: Millions of men worldwide are affected by the complicated disease of prostate cancer, which is most common in areas with high socioeconomic indices. There is growing proof indicating that not all cases of prostate tumors are the same as well as that monitoring techniques and prostate-specific localization therapies are harmless methods of dealing with this mild illness. Plant-based chemicals are believed to be an important reservoir of novel bioactive compounds with a range of different chemical motifs. Aim: The potential of tubulin-targeting medications to target Micro tubulin mechanisms and disrupt important cellular processes which include mitosis, cell signalling, cytoplasmic trafficking and angiogenesis is what makes them such effective cancer therapies. Methods: The current research uses a variety of applications for emphasizing the drug-like properties, toxicology testing, and in silico analysis of numerous phytochemicals in prostate cancer by using the NPACT (Naturally occurring plant-based anti-cancer compound) data bank, Auto dock, Biovia discovery studio for the preparation of target protein and interaction between targeted protein site and Phytocompounds. Result and Conclusion: outcomes of the in silico screening, such as the discovery of possible bioactive substances or interested targets. The nine phytochemicals exhibited the greatest docking results, proving they are potent inhibitors of prostate tumors. To verify the computational results, compare the in silico assumptions with empirical information or previously published literature. To reinforce the conclusions, illustrations such as modifications to conformation, binding ways, or sequences of interactions. This in silico study is a critical first step in realizing the enormous promise of plant-based constituents in the field of drugs.