Archaeobotanical Elucidation of Moringa oleifera: It’s Biological, Ethnopharmacological and Phytochemical Activities
Authors
-
School of Pharmacy, The Neotia University, Sarisa, Diamond Harbour Road, South 24 Parganas, Jhinga – 743368, West Bengal ,IN
Sujayita Mazumder -
School of Pharmacy, The Neotia University, Sarisa, Diamond Harbour Road, South 24 Parganas, Jhinga – 743368, West Bengal ,INSomsubhra Ghosh
-
School of Pharmacy, The Neotia University, Sarisa, Diamond Harbour Road, South 24 Parganas, Jhinga – 743368, West Bengal ,INSankhadip Bose
-
SRM College of Pharmacy, SRM Institute of Science and Technology, Intra College Rd, Potheri, SRM Nagar, Kattankulathur - 603203, Tamil Nadu ,INAtyurmila Chakraborty
-
School of Pharmacy, The Neotia University, Sarisa, Diamond Harbour Road, South 24 Parganas, Jhinga – 743368, West Bengal ,INSubas Chandra Dinda
DOI:
https://doi.org/10.18311/jnr/2024/35299Keywords:
Architecture of Plant, Biogas Production, Ethnopharmacology, Phytochemical Compounds, Superfood SupplementAbstract
Moringa oleifera (family Moringaceae) was originally first found in India now it has been cultivated in various regions of the world. The architecture of a plant is an endogenous morphological growth pattern through which the plant develops its shape. Analysing plant architecture is important for the understanding of plant growth, and branching patterns. A high source of natural phytochemical compounds is present in Moringa, and plant parts have high nutritional value. Moringa is used in animal feeding systems to fight malnutrition in India and Africa. The potency of Moringa is evaluated for its effectiveness on rats and humans, among other animals. It is a safe, affordable, and effective pharmacological and dietary option. M. oleifera is a fantastic food crop with clear economic, medicinal, and nutritional advantages. Moringa contains Alkaloids, vincristine, vinblastine, kaempferitrin, isoquercitrin, kaempherol, polyphenols and flavonoids that may be present in Moringa. Moringa leaves contain vitamin C and beta-carotene which act against free radicals. Quercetin acts as an antioxidant property and chlorogenic acid, polyphenol act as an antioxidant and anticancer activity. The presence of 4-L-rhamnosyloxybenzyl isothiocyanate is responsible for showing the antibacterial activity of the root. Moringa is used as a superfood supplement and has immune booster properties. Ethnopharmacological activity of Moringa includes antibacterial, anti-inflammatory, antioxidant, antidiabetic, analgesic, chronic periodontitis, antipyretic, cardio protecting, anti-asthmatic, antispasmodic, promoting breast milk production, biogas production and water filtration properties. Numerous studies have shown that it can control physiological processes, as well as both prevent and treat illnesses. Nowadays researchers developed Moringa oleifera leaf nanoparticles that show antidiabetic and antiproliferative activity against human cancer lines and others. In clinical or human studies, lower doses of Moringa were not associated with any negative effects or toxicities.
Downloads
Metrics
Published
How to Cite
Issue
Section
Categories
License
Copyright (c) 2024 Sujayita Mazumder, Somsubhra Ghosh, Sankhadip Bose, Atyurmila Chakraborty, Subas Chandra Dinda (Author)
This work is licensed under a Creative Commons Attribution 4.0 International License.
Accepted 2024-02-06
Published 2024-04-01
References
Gopalakrishnan L, et al. Moringa oleifera: A review on nutritive importance and its medicinal application. Food Sci Hum Wellness. 2016; 5:49–56. https://doi.org/10.1016/j.fshw.2016.04.001
Fahey JW. Moringa oleifera: A review of the medical evidence for its nutritional, therapeutic and prophylactic properties. Trees Life J. 2005; 1(5).
Fugli LJ. The Moringa Tree: A local solution to malnutrition church world service in Senegal. 2005.
Anwar F, Latif S, Ashraf M, Gilani AH. Moringa oleifera: A food plant with multiple medicinal uses. Phyther Res. 2007; 21(1):17–25. https://doi.org/10.1002/ptr.2023
Koul B, Chase N. Moringa oleifera Lam: Panacea to several maladies. J Chem Pharm Res. 2015; 7(6):687–707.
Paliwal R, Sharma VP. A review on horse radish tree (Moringa oleifera): A multipurpose tree with high economic and commercial importance. Asian J Biotechnol. 2011; 3(4):317–28. https://doi.org/10.3923/ajbkr.2011.317.328
Moyo B, Masika P, Hugo A, Muchenje V. Nutritional characterization of Moringa (Moringa oleifera Lam.) leaves, African J Biotechnol. 2011; 10:12925–33. https://doi.org/10.5897/AJB10.1599
Gopalakrishnan L, Doriya K, Kumar DS. Moringa oleifera: A review on nutritive importance and its medicinal application. Food Sci Hum Wellness. 2016; 5:49–56. https://doi.org/10.1016/j.fshw.2016.04.001
Ijarotimi OS, Adeoti OA, Ariyo O. Comparative study on nutrient composition, phytochemical, and functional characteristics of raw, germinated, and fermented Moringa oleifera seed flour. Food Sci Nutr. 2013; 1:452–63. https://doi.org/10.1002/fsn3.70
Sallau B, Mada, SB, Ibrahim S, Ibrahim U. Effect of boiling, simmering and blanching on the antinutritional content of Moringa oleifera leaves. Int J Food Nutr Saf. 2012; 2:1–6.
Yang R, Chang L, Hsu J, Weng B, Palada C, Chadha ML, Levassuer V. Nutritional and functional properties of Moringa leaves–From germplasm, to plant, to food, to health. Am Chem Soc. 2006; p. 1–17.
Kiranawati TM, Nurjanah N. Improvement of noodles recipe for increasing breastmilk: design of the Moringa noodles. Am J Food Sci Technol. 2014; 2(3):88–92. https://doi.org/10.12691/ajfst-2-3-2
Mishra, SP, SinghP, Singh S. Processing of Moringa oleifera leaves for human consumption. Bull Env Pharmacol Life Sci. 2012; 2(1):28–31.
Asiedu-Gyekye IJ, Frimpong-Manso S, Awortwe C, Antwi DA, NAK. Micro- and macroelemental composition and safety evaluation of the nutraceutical Moringa oleifera leaves. J Toxicol. 2014; 2014. https://doi.org/10.1155/2014/786979
Bennett RN, Mellon FA, Foidl N, Pratt JH, Dupont MS, Lionel Perkins, et al. Profiling glucosinolates and phenolics in vegetative and reproductive tissues of the multi-purpose trees Moringa oleifera L. (Horseradish Tree) and Moringa stenopetala L. J Agric Food Chem. 2003; 51(12):3546–53. https://doi.org/10.1021/jf0211480
Bhattacharya SB, Das AK, Banerji N. Chemical investigations on the gum exudate from Sajna (Moringa oleifera). Carbohydr Res. 1982; 102(1):253–62. https://doi.org/10.1016/S0008-6215(00)88067-2
Faizi S, Siddiqui BS, Saleem R, Siddiqui S, Aftab K, Gilani AH. Isolation and structure elucidation of new nitrile and mustard oil glycosides from Moringa oleifera and their effect on blood pressure. J Nat Prod. 2004; 57(9):1256–61. https://doi.org/10.1021/np50111a011
Ruckmani K, Kavimani S, Anandan R JB. Effect of Moringa oleifera Lam on paracetamol-induced hepatotoxicity. Indian J Pharm Sci. 1968; 60(1):33–5.
Aney JS, Tamble R, Kulkarni M, Bhise K. Pharmacological and pharmaceutical potential of Moringa oleifera: A review. J Pharm Res. 2009; 2(9):1424–6.
Dutta DAK. Moringa oleifera: A review on its importance and medicinal application in recent age. World J Pharm Pharm Sci. 2017; 6:1830–9.
Dahot MU. Vitamin contents of the flowers and seeds of Moringa oleifera. Pak J Biochem. 1988; 21:1–24.
Faizi S, Siddiqui B, Saleem R, Siddiqui S, Phytochemistry KA. Fully acetylated carbamate and hypotensive thiocarbamate glycosides from Moringa oleifera. Phytochemistry. 1995; 38(4):957–63. https://doi.org/10.1016/0031-9422(94)00729-D
Mehta LK, Balaraman R, Amin AH, Bafna PA GO. Effect of fruits of Moringa oleifera on the lipid profile of normal and hypercholesterolaemic rabbits. J Ethnopharmacol. 2003; 86:191–5. https://doi.org/10.1016/S0378-8741(03)00075-8
Cerf ME. Beta cell dysfunction and insulin resistance. Front Endocrinol (Lausanne). 2013; 4:1–12. https://doi.org/10.3389/fendo.2013.00037
Wright JR, Scism-bacon JL. Oxidative stress in type 2 diabetes: the role of fasting and postprandial glycaemia. Int J Clin Pract. 2006; 60(3):308–14. https://doi.org/10.1111/j.1368-5031.2006.00825.x
Prentki M, Nolan CJ. Islet beta cell failure in type 2 diabetes. J Clin Invest. 2006; 116(7):1802–12. https://doi.org/10.1172/JCI29103
Kamalakkannan, N, Prince PSM. Antihyperglycaemic and antioxidant effect of rutin, a polyphenolic flavonoid, in streptozotocin-induced diabetic wistar rats. Basic Clin Pharmacol Toxicol. 2006; 98(1):97–103. https://doi.org/10.1111/j.1742-7843.2006.pto_241.x
Nair M, Varghese C, Papers RS. Cancer: Current scenario, intervention strategies and projections for 2015. Burd Dis India. 2005. p. 219–25.
Das BR, Kurup PA, Narasimha Rao PL. Antibiotic principle from Moringa pterygosperma. VII. Antibacterial activity and chemical structure of compounds related to pterygospermin. Indian J Med Res. 1957; 45(2):191–6.
Eilert U, Wolters B, Nahrstedt A. The antibiotic principle of seeds of Moringa oleifera and Moringa Stenopetala. Planta Med. 1981; 42(1):55–61. https://doi.org/10.1055/s-2007-971546
Nikkon F, Saud ZA, Rehman MH HM.In vitro antimicrobial activity of the compound isolated from chloroform extract of Moringa oleifera Lam. Pak J Biol Sci. 2003; 22:1888–90. https://doi.org/10.3923/pjbs.2003.1888.1890
Tiloke C, Phulukdaree A, Chuturgoon AA. The antiproliferative effect of Moringa oleifera crude aqueous leaf extract on cancerous human alveolar epithelial cells. BMC Complement Altern Med. 2013; 13:226–33. https://doi.org/10.1186/1472-6882-13-226
Jung IL. Soluble extract from Moringa oleifera leaves with a new anticancer activity. PLoS One. 2014; 9(4):1–10. https://doi.org/10.1371/journal.pone.0095492
Leelawat S, Leelawat K. Moringa oleifera extracts induce cholangiocarcinoma cell apoptosis by induction of reactive oxygen species production. Int J Pharmacogn Phytochem Res. 2014; 6:183–9.
Rao A, Devi P, Kamath R. In vivo radioprotective effect of Moringa oleifera leaves. Indian J Exp Biol. 2001; 39:858–63.
Makonnen E, Hunde A. Hypoglycaemic effect of Moringa stenopetala aqueous extract in rabbits. Phytother Res. 1997; 11:147–8. https://doi.org/10.1002/(SICI)1099-1573(199703)11:2<147::AID-PTR41>3.0.CO;2-V
Guevara AP, Vargas C, Fujiwara SH. An antitumor promoter from Moringa oleifera Lam. Mutat Res. 1999; 440:181–8. https://doi.org/10.1016/S1383-5718(99)00025-X
Murakami A, Kitazono Y, Jiwajinda S, Koshimizu K. Niaziminin, a thiocarbamate from the leaves of Moringa oleifera, holds a strict structural requirement for inhibition of tumor-promoter-induced Epstein-Barr virus. Planta Med. 1998; 64:319–23. https://doi.org/10.1055/s-2006-957442
Ndabigengesere A, Narasiah KS. Quality of water treated by coagulation using Moringa oleifera seeds. Water Res. 1998; 32:781–91. https://doi.org/10.1016/S0043-1354(97)00295-9
Sharma V, Paliwal R. Isolation and characterization of saponins from Moringa oleifera (Moringaceae) pods. Int J PharmPharm Sci. 2013; 5(1):179-83.
Muyibi S, Evison LM. Moringa oleifera seeds for softening hardwater. Water Res. 1995; 29(4):1099–105. https://doi.org/10.1016/0043-1354(94)00250-B
Ndabigengesere A, Narasiah, KS, Talbot BG. Active agents and mechanism of coagulation of turbid waters using Moringa oleifera. Water Res. 1995; 29:703–10. https://doi.org/10.1016/0043-1354(94)00161-Y
Okuda T, Baes A, Nishijima, W, Okada M. Improvement of extraction method of coagulation active components from Moringa oleifera seed. Water Res. 1999; 33(15):3373–8. https://doi.org/10.1016/S0043-1354(99)00046-9
Broin M, Santaella C, Cuine S, Kokou K, Peltier G, Joet T. Flocculent activity of a recombinant protein from Moringa oleifera Lam. seeds. Appl Microbiol Biotechnol. 2002; 60(1–2):114–9. https://doi.org/10.1007/s00253-002-1106-5
Casey TJ. Unit treatment processes in water and wastewater engineering. John Wiley and Sons: London. 1997; 280.
Sutherland J, Folkard G, Grant WD. Natural coagulants for appropriate water treatment: a novel approach. John Wiley Sons London. 1990; 8(4):30–2. https://doi.org/10.3362/0262-8104.1990.020
Mazumder S, Biswas GR, Saha A. Effect of nanomaterials in catheter related nosocomial infection. Journal of Medical Pharmaceutical and Allied Sciences. 2023; 12–14:5971-5. https://doi.org/10.55522/jmpas.V12I4.5142
Sharma P, Kumari, P, Srivastava, MM, Srivastava S. Removal of cadmium from aqueous system by shelled Moringa oleifera Lam. seed powder. Bioresour Technol. 2006; 97:299–305. https://doi.org/10.1016/j.biortech.2005.02.034
Lalas, S, Tsaknis J. Extraction and identification of natural antioxidant from the seeds of the Moringa oleifera tree variety of Malawi. Jam Oil Chem Soc. 2002; 79(7):677–83. https://doi.org/10.1007/s11746-002-0542-2
Siddhuraja, P, Becker K. Antioxidant properties of various solvent extracts of total phenolic constituents from three different agroclimatic origins of drumstick tree (Moringa oleifera Lam.) leaves. J Agric Food Chem. 2003; 51(8):2144–55. https://doi.org/10.1021/jf020444
Shukla S, Mathur R, Prakash AO. Antifertility profile of the aqueous extract of Moringa oleifera roots. J Ethnopharmacol. 1988; 22(1):51–62. https://doi.org/10.1016/0378-8741(88)90230-9
Hukkeri VI, Nagathan CV, Karadi RV, Patil BS. Antipyretic and wound healing activities of Moringa. Indian J Pharm Sci. 2006; 68(1):124–6. https://doi.org/10.4103/0250-474X.22985
Selvakumar, D, Natarajan P. Hepato-protective activity of Moringa oleifera Lam leaves in carbon tetrachloride induced hepato-toxicity in albino rats. Phcog Mag. 2008; 4(13):97–8.
Zheng Y, Zhang Y, Wu J. Yield and quality of Moringa oleifera under different planting densities and cutting heights in southwest China. Ind Crops Prod. 2016; 30(91):88–96. https://doi.org/10.1016/j.indcrop.2016.06.032
Borstlap AC, Schuurmans J. Kinetics of L-valine uptake in tobacco leaf discs. Comparison of wild-type, the digenic mutant Valr-2, and its monogenic derivatives. Planta. 1988; 176(1):42–50. https://doi.org/10.1007/BF00392478
Nambiar VS, Parnami S. Standardization and organoleptic evaluation of drumstick (Moringa oleifera) leaves incorporated into traditional Indian recipes. Trees. 2008; 3:1–7.
Pareek A, Pant M, Gupta MM, Kashania P, Ratan Y, Jain V, Pareek A, Chuturgoon AA. Moringa oleifera: An updated comprehensive review of its pharmacological activities, ethnomedicinal, phytopharmaceutical formulation, clinical, phytochemical, and toxicological aspects. Int J Mol Sci. 2023; 24(3):2098. https://doi.org/10.3390/ijms24032098
Kashyap P, Kumar S, Riar CS, Jindal N, Baniwal P, Guine RPF, Correia PMR, Mehra R, Kumar H. Recent advances in drumstick (Moringa oleifera) leaves bioactive compounds: composition, health benefits, bioaccessibility, and dietary applications. Antioxidants (Basel). 2022; 11(2):402. https://doi.org/10.3390/antiox11020402
0.35
24
0.161