Pharmaceutical Standardization and Comparative Study of Varunadi Kvatha Churna as Varunadi Ghana Vati/Tablet and Varunadi Pravahi Kvatha

Abstract

Background: In Ayurveda, there are many types of potent dosage forms available with their different specifications, anupan, preparation procedure and shelf life. The preparation of medicines of herbal drug origin is generally included in the Bhaishajya Kalpana section. In Bhaishajya Kalpana there are five basic dosage forms necessary to prepare formulations from herbal origin drugs i.e. Swarasa, Kalka, Kvatha, Hima and Phanta. These five basic formulations are potent dosage forms which can moulded into different finished formulations. Aim: The objectives of this study were to prepare and standardise the Varunadi Kvatha Churna as Varunadi Ghana Vati/Tablet and Varunadi Pravahi Kvatha with a comparative study. Methods: Firstly, kvatha churna was prepared as per the master formula. The kvatha churna was then used in two different ways i.e. firstly it was used to prepare Varunadi Ghana Vati (Tablet) without using any additives as it acts as a self-binder. On the other hand, Pravahi kvatha was prepared which is a self-generated alcohol formulation, in which dhataki pushpa, gudda and babool are added as a fermentation initiator and additives. Results: Physicochemical parameters do not show significant variation. According to the TLC profile, the Ghana Vati has six spots i.e. having much more active constituents than the Pravahi kvatha having two spots. Therefore, according to the parameters, it might be stated that the Pravahi kvatha has much more stability than the Ghana Vati. But as far as palatability and activity are concerned Ghana Vati is comparatively better than Pravahi kvatha Conclusion: Converting Varunadi Kvatha Churna into Varunadi Ghana Vati, Varunadi Pravahi Kvatha provides several benefits related to ease of use, dosage precision, and patient preference. Hence based on observation we stated that the Varunadi Ghana Vati has a better choice of dosage form as compared to Varunadi Pravahi Kvatha, although it has better stability.