Wound Healing Activity of the Seed Kernels of Caesalpinia crista Linn.

Abstract

Objective: To screen the wound healing activity of different extracts of seed kernels of Caesalpinia crista Linn in excision, incision and dead space wound models in albino rats. Materials and methods : Seed kernels of Caesalpinia crista Linn was defatted completely with petroleum ether (60-80°C) and then marc was subjected to continuous extraction using alcohol. The concentrated alcoholic extract was subjected to fractionation by solvent ether, ethyl acetate butanone and butanol in succession. Petroleum ether extract, alcoholic extract and four fractions were tested for various preliminary phytoconstituents and screened for wound healing activity in excision, incision and dead space wound models in albino rats. Results: Ethyl acetate fraction of seed kernel of Caesalpinia crista Linn has shown better wound healing activity in incision, excision and dead space wound models as compared to alcoholic extract and solvent ether fraction. While petroleum ether extract, butanol fraction and butanone fraction has shown the least effective wound healing activity. Conclusion: From the result obtained it can be concluded that ethyl acetate fraction of seed kernel of Caesalpinia crista Linn has significant wound healing property.