Administration of Purwoceng (Pimpinella alpina Molk) Improves Oxidative Stress Biomarker Following UVC Irradiation in Spargue-Dawley Male Rats

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Authors

  • Taufiqurrachman Nasihun
     Department of Biochemistry, Medical Faculty of Sultan Agung Islamic University, Semarang, Central Java ,ID
  • Eni Widayati
     Department of Chemistry, Medical Faculty of Sultan Agung Islamic University, Semarang, Central Java ,ID

DOI:

https://doi.org/10.18311/jnr/2016/7684

Keywords:

MDA, 8-OHdG, Oxidative Stress Biomarker, Pimpinella alpine Molk, UVC
Pharmacognosy

Abstract

Introduction: UVC may induce oxidative stress mediated by ROS. Pimpinella alpina Molk (PaM) have been utilized by aging male as rejuvenation remedy. Objective: To elucidate the PaM effect on oxidative stress biomarker in rats. Methods: 25 of Sprague-Dawley male rats were divided into 5 groups, PaM with a dosage of 50, 100, and 150 mg were administered during 15 days to evaluate the biomarker of oxidative stress following UVC irradiation for 30 minutes beforehand. The oxidative stress biomarkers were measured by TBARS and FRAP assay respectively. Results: Post Hoc analysis demonstrated that MDA and 8-OHdG concentration in PaM group were significantly lower (p < 0.001), otherwise the concentration of TAC in PaM group were significantly higher, p < 0.001. Conclusion: Administration of PaM with 50, 100, and 150 mg dosage capable of improving oxidative stress biomarker in Sprague-Dawley male rats.

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Published

2016-11-16

How to Cite

Nasihun, T., & Widayati, E. (2016). Administration of Purwoceng (<I>Pimpinella alpina</I> Molk) Improves Oxidative Stress Biomarker Following UVC Irradiation in Spargue-Dawley Male Rats. Journal of Natural Remedies, 16(3), 115–124. https://doi.org/10.18311/jnr/2016/7684

Issue

Volume 16, Issue 3, July 2016

Section

Articles
Crossref
Scopus
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Europe PMC
Received 2016-09-13
Accepted 2016-10-21
Published 2016-11-16

 

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