Toxic Impacts of Cypermethrin on Behavior and Histology of Certain Tissues of Albino Rats

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Authors

  • K. K. Grewal
     Department of Zoology, S.G.N. Khalsa College, Sri Ganganagar, Rajasthan ,IN
  • G. S. Sandhu
     Department of Zoology, S.G.N. Khalsa College, Sri Ganganagar, Rajasthan ,IN
  • Ranjit Kaur
     Department of Zoology, S.G.N. Khalsa College, Sri Ganganagar, Rajasthan ,IN
  • R. S. Brar
     Departments of Veterinary Pathology, GADVASU, Ludhiana ,IN
  • H. S. Sandhu
     Veterinary Pharmacology and Toxicology, GADVASU, Ludhiana ,IN

Keywords:

Albino rats, cypermethrin, histopathology, insecticides, pyrethroids
Molecular Biology

Abstract

In the present investigation, the behavioral, morphological, and histopathological effects of cypermethrin, a widely used synthetic pyrethroid insecticide, was ascertained in male and female albino rats (Rattus norvegicus). Cypermethrin administered at repeated oral doses of 5 and 20 mg/kg/day for 30 days produced varying degree of mild to moderate toxic symptoms and behavioral changes in both male and female rats. The lower dose produced very mild toxicosis characterized by intermittent diarrhea, decreased feed intake, and thick eye discharge, whereas higher dose displayed mild to moderate toxicosis with diarrhea, decreased feed intake, loss of body weight, dyspnoea, ataxia, eye discharge, and salivation. Two female and one male albino rats died between 23 to 28 days after displaying signs of incoordination and tremors. Repeated oral doses of cypermethrin for 30 days enhanced the relative weight of liver and heart, but significantly decreased that of brain, kidneys, and testes. Microscopically, cypermethrin produced neuronal degeneration and increase in glial cells in brain, and disorganization of hepatic laminae, increase in sinusoid, and necrosis of hepatocytes in liver. Section of kidney displayed hemorrhage and sloughing off renal epithelial cell in the convoluted tubules, shrinkage of glomeruli, and necrosis of renal tubules. Repeated administration of cypermethrin also produced hemorrhages within myocardium, disruption of branching structure, and loss of striation of cardiac tissue; thickening of alveolar septa in lungs, partial to extensive loss of various stages of spermatogenesis in testes, and loss of follicular cells and oocytes in ovaries. The study suggested that repeated oral exposure of cypermethrin has considerable harmful effects on body organs in R. norvegicus.

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Published

2018-05-16

How to Cite

Grewal, K. K., Sandhu, G. S., Kaur, R., Brar, R. S., & Sandhu, H. S. (2018). Toxic Impacts of Cypermethrin on Behavior and Histology of Certain Tissues of Albino Rats. Toxicology International, 17(2), 94–98. Retrieved from https://informaticsjournals.co.in/index.php/toxi/article/view/21186

Issue

Volume 17, Issue 2, July-December 2010

Section

Original Research
Received 2018-05-15
Accepted 2018-05-15
Published 2018-05-16

 

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