Hepatoprotective Effect of Curcumin on Lindane-induced Oxidative Stress in Male Wistar Rats

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Authors

  • Rambir Singh
     Departments of Biomedical Sciences and Zoology, Bundelkhand University, Jhansi, Uttar Pradesh ,IN
  • Poonam Sharma
     Departments of Biomedical Sciences and Zoology, Bundelkhand University, Jhansi, Uttar Pradesh ,IN

Keywords:

Curcumin, hepatotoxicity, lindane, Wistar rat
Virology

Abstract

Lindane, an organochlorine pesticide, is recognized as a major public health concern because of its potential toxic effects on human health. Its persistence in the body fluids may lead to continuous blood circulation, liver exposure and hepatotoxicity. The present study was undertaken to evaluate the possible protective role of curcumin on lindane-induced hepatotoxicity. Forty-two healthy adult male Wistar rats were divided into seven groups of six rats each. Group I was given dimethylsulfoxide. A single dose of lindane (60 mg/kg bw) was given to group II. Lindane (30 mg/kg bw) was given daily to group III for 14 days. Treatment with curcumin (100 and 200 mg/kg) was given to groups IV and V before (pretreatment) and to groups VI and VII after (post-treatment) 14 days exposure of lindane. Oxidative stress parameters and antioxidative enzymes were investigated in the liver of exposed and treated rats. A significant increase in lipid peroxidation, and decrease in glutathione level, Superoxide dismutase catalase, glutathione-S-transferase, glutathione peroxidase, glutathione reductase and NADPH quinine reductase activities was observed in liver of rats exposed to lindane. Curcumin (Pre- and post-treatment) nearly normalized all these parameters. Histological alterations were also observed in the liver tissue after lindane exposure. Treatment with curcumin significantly prevented the lindane-induced histological alterations. In conclusion, curcumin has protective effect over lindane-induced oxidative damage in rat liver.

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Published

2018-05-18

How to Cite

Singh, R., & Sharma, P. (2018). Hepatoprotective Effect of Curcumin on Lindane-induced Oxidative Stress in Male Wistar Rats. Toxicology International, 18(2), 124–129. Retrieved from https://informaticsjournals.co.in/index.php/toxi/article/view/21257

Issue

Volume 18, Issue 2, July-December 2011

Section

Articles
Received 2018-05-17
Accepted 2018-05-17
Published 2018-05-18

 

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