Toxicological Effects of Cypermethrin on Female Albino Rats

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Authors

  • G. K. Sangha
     Departments of Zoology, Punjab Agricultural University, Ludhiana-141004 ,IN
  • Kamalpreet Kaur
     Departments of Zoology, Punjab Agricultural University, Ludhiana-141004 ,IN
  • K. S. Khera
     Departments of Zoology, Punjab Agricultural University, Ludhiana-141004 ,IN
  • Balwinder Singh
     Departments of Entomology, Punjab Agricultural University, Ludhiana-141004 ,IN

Keywords:

Cypermethrin, endocrine glands, female rats, heart, kidney, liver, lungs, spleen
Toxicology

Abstract

A study was undertaken to evaluate the effects of cypermethrin on reproduction of female albino rats. The experimental rats were fed cypermethrin at 50 mg/kg b. wt. continuously for a period of 2 and 4 weeks. Feed and water intake was also noted daily for control, vehicle treated and cypermethrin-treated rats. It was observed that there was no effect on feed and water intake in treated rats as compared to the control group. Chronic exposure to cypermethrin for 4 weeks resulted in loose fecal pellets and hyperirritability in the treated rats. Treatment related mortality also occurred at the 4th wk of treatment. Significant changes in body weight and various organ weights due to cypermethrin were observed along with disruption of estrous cycle in rats. The body weight gain in treated rats was lower at both 2 and 4 weeks as compared to the control rats. The weight of liver and spleen decreased, while that of kidneys increased as compared to the control rats. Thyroid and adrenal showed increase in weight at both 2 and 4 weeks of treatments.

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Published

2018-05-21

How to Cite

Sangha, G. K., Kaur, K., Khera, K. S., & Singh, B. (2018). Toxicological Effects of Cypermethrin on Female Albino Rats. Toxicology International, 18(1), 5–8. Retrieved from https://informaticsjournals.co.in/index.php/toxi/article/view/21280

Issue

Volume 18, Issue 1, January-June 2011

Section

Original Research
Received 2018-05-18
Accepted 2018-05-18
Published 2018-05-21

 

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