Ameliorative Potential of Psidium guajava on Hemato-biochemical Alterations in Arsenic-exposed Wistar Rats

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Authors

  • Neeraj Tandan
     Departments of Veterinary BiocheCollege of Veterinary Science and Animal Husbandry, Anjora, Durg, Chhattisgarh ,IN
  • Manju Roy
     Departments of Veterinary Biochemistry, College of Veterinary Science and Animal Husbandry, Anjora, Durg, Chhattisgarh ,IN
  • Sushovan Roy
     Departments of Veterinary Biochemistry, College of Veterinary Science and Animal Husbandry, Anjora, Durg, Chhattisgarh ,IN

Keywords:

Hemato-biochemical, rats, sodium arsenite, toxicity Original Article products
Pathology

Abstract

The present study attempts to investigate the effects of Psidium guajava (P. guajava) when administered in combination with sodium arsenite @ 20 ppm in drinking water with the aim of achieving normalization of altered biochemical, hematological parameters suggestive of hepatic damage and depletion of inorganic arsenic following chronic arsenic exposure. Thirty adult Wistar rats were given 20 ppm arsenic for eight weeks along with hydro alcoholic leaf extract of P. guajava at a dose of 100 mg/kg body weight wt. (orally) (once daily for eight weeks). Arsenic exposure led to significant depletion of hemoglobin, red blood cells (RBC) and packed cell volume (PCV) but elevated leucocyte count (TLC). There was a significant increase (P<0.01/P<0.05) in serum aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphotase (ALP), acid phosphotase (ACP) and blood glucose whereas decrease in total protein level in arsenic-exposed untreated animals. The changes were accompanied by a significant elevation in blood and soft-tissue arsenic concentration. Co-administration of P. guajava was most effective not only in reducing arsenic-induced hematological and biochemical alterations but also in depleting arsenic from blood and soft tissues following arsenic exposure. We thus recommend combined leaf extract of P. guajava for achieving optimum effects of chelation therapy.

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Published

2018-05-25

How to Cite

Tandan, N., Roy, M., & Roy, S. (2018). Ameliorative Potential of <i>Psidium guajava<i> on Hemato-biochemical Alterations in Arsenic-exposed Wistar Rats. Toxicology International, 19(2), 121–124. Retrieved from https://informaticsjournals.co.in/index.php/toxi/article/view/21352

Issue

Volume 19, Issue 2, May-August 2012

Section

Original Research

 

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