Hematobiochemical Evaluation of Dermal Subacute Cypermethrin Toxicity in Buffalo Calves

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Authors

  • Shabir Ahmad Dar
     Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, Punjab ,IN
  • Rajdeep Kaur
     Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, Punjab ,IN
  • Rajdeep Kaur
     Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, Punjab ,IN

Keywords:

Biochemical, buffalo calves, cypermethrin, dermal, hematology, toxicity
Endodontics

Abstract

Dermal exposure of cypermethrin, a type II synthetic pyrethroid insecticide, at dose rate of 0.25% for 14 consecutive days produced mild signs of toxicity in buffalo calves. It produced significant elevation in the levels of alanine aminotransferase (ALT; 39.5%), aspartate aminotransferase (AST; 32.0%), blood urea nitrogen (BUN; 57.7%), and plasma creatinine (30.0%). Cypermethrin also produced significant decrease in the hemoglobin (Hb) concentration (5.4%), packed cell volume (PCV; 3.4%), and total erythrocytic count (4.0%). Additionally, there was a significant increase in erythrocytic sedimentation rate (ESR; 3.1%). On the basis of the present study, it can be concluded that cypermethrin induces significant biochemical and hematological alterations in buffalo calves when exposed dermally.

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Published

2018-06-04

How to Cite

Dar, S. A., Kaur, R., & Kaur, R. (2018). Hematobiochemical Evaluation of Dermal Subacute Cypermethrin Toxicity in Buffalo Calves. Toxicology International, 21(3), 283–287. Retrieved from https://informaticsjournals.co.in/index.php/toxi/article/view/21409

Issue

Volume 21, Issue 3, September - December 2014

Section

Original Research
Received 2018-06-01
Accepted 2018-06-01
Published 2018-06-04

 

References

Leahey JP. Metabolism and environmental degradation, in The Pyrethroid Insecticides. In: Leahey JP, editor. London: Taylor and Francis; 1985. p. 263-342.

El"‘Tawil OS, Abdel"‘Rahman MS. The role of enzyme induction and inhibition on cypermethrin hepatotoxicity. Pharmacol Res 2001;44:33"‘40.

Nagarjuna A, Prasad S, Mohyuddin S, Sekhar P, Doss P. Alteration in protein metabolic profiles in gastrocnemius muscle tissue of rats during cypermethrin toxicosis. J Indian Soc Toxicol 2008;4:17"‘21.

Manna S, Bhattacharyya D, Basak D, Mandal T. Single oral dose toxicity study of α"‘cypermethrin in rats. Indian J Pharmacol 2004;36:25"‘8.

Patel S, Pandey AK, Bajpayee M, Parmar D, Dhawan A. Cypermethrin"‘induced DNA damage in organs and tissues of the mouse: Evidence from the comet assay. Mutat Res 2006;607:176"‘83.

Saxena PN, Chauhan LK, Gupta SK. Cytogenetic effects of formulation of cypermethrin in root meristem cells of Allium sativum: Spectroscopic basis of chromosome damage. Toxicology 2005;216:244"‘52.

Rosita G, Nasuti C, Falcioni G, Cantalamessa F. Lymphocyte DNA damage in rats exposed to pyrethroids: Effect of supplementation with vitamins E and C. Toxicol 2003;203:17"‘26.

Vassault A, Maire I, Sebille L, Bozon D. Recommendations for determining the concentration catalytically of the lactate dehdrogenase in human serum at + 30°C. Annales De Biologic Clinigue 1982;40:123"‘28.

Talke H, Schubert GE. Enzymatic urea determination in the blood and serum in the warburg optical test. Klin Wochenschr 1965;43:174"‘5.

Henry RJ, Cannon DC, Winkelman JW, eds. Clinical chemistry. Principles and techniques, 2nd ed. Hagerstown, MD: Harper and Row; 1974. p. 1003-109.

Expert panel of the International Federation of Clinical Chemistry (IFCC). Clin Chem Acta 1976;70:F19336.

Benjamin MM. Outline of veterinary clinical pathology. 3rd ed. Ludhiana: Kalyani Publisher; 1985. p. 25, 48, 60.

Aslam F, Khan A, Khan MZ, Sharaf S, Gul ST, Saleemi MK. Toxico"‘pathological changes induced by cypermethrin in broiler chicks: Their attenuation with Vitamin E and selenium. Exp Toxicol Pathol 2010;62:441"‘50.

Nair RR, Abraham MJ, Lalithakunjamma CR, Nair ND, Aravindakshan CM. Haemtological and biochemical profile in sub lethal toxicity of cypermethrin in rats. Int J Biol Med Res 2010;1:211"‘4.

Padma S, Ashok KS. Cypermethrin induced biochemical alterations in the blood of albino rats. Jordan J Biol Sci 2010;3:111"‘4.

Yousef MI, El"‘Demerdash FM, Al"‘Salhen KS. Protective role of isoflavones against the toxic effect of cypermethrin on semen quality and testosterone levels of rabbits. J Environ Sci Health 2003;38:463"‘78.

Braun JP, Siest G, Rico AG. Uses of gamma"‘glutamyltransferase in experimental toxicology. Adv Vet Sci Comp Med 1987;31:151"‘72.

Brar RS , Sandhu HS, Singh A. Veterinary clinical diagnosis by laboratory methods. Vol. 1. Ludhiana-New Delhi: Kalyani Publishers; 2000; p. 98-102.

Tennant BC. Hepatic function. In: Kaneko JJ, Harvey JW, Bruss ML, editors. Clinical Biochemistry of Domestic Animals. 5th ed. San Diego: Academic Press; 1997. p. 327"‘52.

Dial SM. Clinicopathologic evaluation of liver. Vet Clin North Am Small Anim Pract 1995;25:257"‘73.

Murray RK, Granner DK, Mayes PA, Rodwell VW. Harpers Biochemistry. 22nd ed. Los Altos: Lange Medical publication; 1990.

Khan A, Faridi HA, Ali M, Khan MZ, Siddique M, Hussain I, et al. Effects of cypermethrin on some clinico"‘hemato"‘biochemical and pathological parameters in male dwarf goats (Capra hircus). Exp Toxicol Pathol 2009;61:151"‘60.