Pheniramine Maleate"‘Induced Rhabdomyolysis and Aki: Is it Fatal?

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Authors

  • Venugopal K
     Department of General Medicine, Vijayanagara Institute of Medical Sciences, Bellary, Karnataka ,IN
  • Mallikarjun Reddy M.
     Department of General Medicine, Vijayanagara Institute of Medical Sciences, Bellary, Karnataka ,IN
  • Bharathraj M. Y.
     Department of General Medicine, Vijayanagara Institute of Medical Sciences, Bellary, Karnataka ,IN
  • Kadappa Jaligidad
     Department of General Medicine, Vijayanagara Institute of Medical Sciences, Bellary, Karnataka ,IN

Keywords:

Acute kidney injury, convulsions, drug"‘induced rhabdomyolysis, pheniramine maleate overdose, respiratory depression
Pharmacology

Abstract

Pheniramine maleate is an easily accessible, over"‘the"‘counterantihistaminic, which is frequently involved in overdoses. Pheniramine has antimuscarinic effect causing tachycardia, dilated pupils, urinary retention, and dry flushed skin, and decreased bowel sounds, confusion, mild increase in body temperature, cardiac arrhythmias, and seizures at lethal doses. It has not been implicated as an important cause of rhabdomyolysis and acute kidney injury (AKI). Rhabdomyolysis causing AKI is rarely reported in the literature. This case report emphasizes the occurrence of nontraumatic rhabdomyolysis in pheniramine maleate overdose which required hemodialysis. Since there is a lack of a specific antidote, treatment is mainly symptomatic and supportive. We report a fatal case of a young male with a very high dose of consumption of pheniramine maleate (4.077 g), which was complicated by seizures, respiratory depression, nontraumatic rhabdomyolysis, and AKI. Despite hemodialysis, ventilator support, and other intensive supportive care, patient could not survive and death ensued due to multiorgan dysfunction syndrome.

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Published

2018-06-04

How to Cite

K, V., M., M. R., M. Y., B., & Jaligidad, K. (2018). Pheniramine Maleate"‘Induced Rhabdomyolysis and Aki: Is it Fatal?. Toxicology International, 21(3), 319–321. Retrieved from https://informaticsjournals.co.in/index.php/toxi/article/view/21417

Issue

Volume 21, Issue 3, September - December 2014

Section

Case Report
Received 2018-06-04
Accepted 2018-06-04
Published 2018-06-04

 

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