Acute Oral Toxicity and Histopathological Study of Combination of Endosulfan and Cypermethrin in Wistar Rats

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Authors

  • Jaya Raj
     ,IN
  • Mohineesh .
     ,IN
  • Ruma Ray
     ,IN
  • T. D. Dogra
     ,IN
  • Anupuma Raina
     ,IN

Keywords:

Behavioral, cypermethrin, endosulfan, histopathological studies, LD50, rat

Abstract

Background: Endosulfan, a neurotoxic organochlorine insecticide and cypermethrin, a synthetic pyrethroid insecticide used to control pests in domestic, industrial, and agricultural situations. Materials and Methods: The present study was carried out to investigate the acute oral toxicity, behavioral and histopathological changes of combination of endosulfan and cypermethrin in albino rats. According to Miller and Tainter analysis method, at 48 h, LD50 value of combination of endosulfan and cypermethrin (ratio 1:1) in rats was found to be 691.83 mg/kg bw by oral gavage. Results: When combination of both these pesticides was administered orally at concentration of 103.72 mg/kg bw, 172.95 mg/kg bw and 207.50 mg/kg bw, respectively, as a single dose, no significant changes in behavior of rats was observed, neither in dosed nor in control group of rats. Combination of endosulfan"‘ and cypermethrin"‘treated rats showed mild histopathological changes in liver and kidney in group IV (207.50 mg/kg BW) as compared to the control. However, no significant changes were observed in brain and small intestine at either dose of combination of endosulfan and cypermethrin with respect to control. Conclusion: Thus, the present study, first of its kind in India, demonstrated the oral toxicity, behavioral, and histo"‘architectual alterations after induction of combination of endosulfan and cypermethrin at acute doses in Wistar rats.

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Published

2018-08-09

How to Cite

Raj, J., ., M., Ray, R., Dogra, T. D., & Raina, A. (2018). Acute Oral Toxicity and Histopathological Study of Combination of Endosulfan and Cypermethrin in Wistar Rats. Toxicology International, 20(1), 61–67. Retrieved from https://informaticsjournals.co.in/index.php/toxi/article/view/21710

Issue

Volume 20, Issue 1, January - April 2013

Section

Original Research
Received 2018-08-09
Accepted 2018-08-09
Published 2018-08-09

 

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