Assessment of Serum Cholinesterase in Rural Punjabi Sprayers Exposed to a Mixture of Pesticides

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Authors

  • ,IN
  • ,IN

Keywords:

Cholinesterase, pesticides, spray workers

Abstract

Serum cholinesterase (SChE) activity is considered as a biomarker and is also taken as an exposure index to assess the low level, chronic residue exposures among sprayers. Thus, cholinesterase activity was studied in the professional rural Punjabi sprayers of Bathinda district in Punjab. This study was made to estimate the irregularities in the level of cholinesterase according to multiple pesticides used by sprayers, exposure periods, age, and body mass index (BMI) of the sprayers. The data generated was statistically analyzed by applying Student's ‘t' test and one"‘way analysis of variance. A positive correlation was found between SChE activity and years of exposure and a significant reduction in SChE activity was observed in younger population. Again, a positive correlation was seen between BMI and SChE inhibition.

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Published

2018-08-09

How to Cite

Dhalla, A. S., & Sharma, S. (2018). Assessment of Serum Cholinesterase in Rural Punjabi Sprayers Exposed to a Mixture of Pesticides. Toxicology International, 20(2), 154–159. Retrieved from https://informaticsjournals.co.in/index.php/toxi/article/view/21722

Issue

Section

Original Research
Received 2018-08-09
Accepted 2018-08-09
Published 2018-08-09

 

References

Bhalli JA, Khan QM, Haq MA, Khalid AM, Nasim A. Cytogenetic analysis of Pakistani individuals occupationally exposed to pesticides in a pesticide production industry. Mutagenesis 2006;21:143"‘8.

Khan KH. Impact of endosulfan on living beings. Int J Biosci 2012;2:9"‘17.

Mathur HB, Agarwal HC, Johnson S, Saikia N. Analysis of pesticide residues in blood samples from villages of Punjab. 2005 Center for science and environment Available from: http://www.downtoearth.org.in. [Last accessed on 2008 Sep 24].

Abdollahi M, Ranjbar A, Shadnia S, Nikfar S, Rezaie A. Pesticides and oxidative stress. Med Sci Monit 2004;10:141"‘7.

Otitoju O, Onwura IN, Otitoju GT, Ugwu CE. Oxidative stress and superoxide dismutase activity in brain of rats fed with diet containing permethrin. Biokemistri 2008;20:93"‘8.

Kumar M, Lakshmi CV, Khanna S. Biodegradation and bioremediation of endosulfan contaminated soil. Bioresour Technol 2008;99:3116"‘22.

Altuntas I, Delibas N, Demirci M, Kilinc I, Tamer N. The effects of methidathion on lipid peroxidation and some liver enzymes: Role of vitamin E and C. Arch Toxicol 2002;76:470"‘3.

Jokanovic M, Prostran M. Pyridinium oximes as cholinesterase reactivators. Structure"‘activity relationship and efficacy in the treatment of poisoning with organophosphorus compounds.Curr Med Chem 2009;16:2177"‘88.

Misra UK, Prasad M, Pandey CM. A study of cognitive function and event related potentials following organophosphate exposure.Electromyogr Clin Neurophysiol 1994;34:197"‘03.

Mekonnen Y, Ejigu D. Plasma cholinesterase level of Ethiopian farm workers exposed to chemical pesticide. Occup Med (Lond) 2005;55:504"‘5.

Zilva JF, Pannall PR. Plasma Enzymes in Diagnosis in Clinical Chemistry in Diagnosis and Treatment. London: Lloyd"‘Luke; 1979. p. 347.

Ecobichon D. Toxic Effects of Pesticides. In: Klaassen CD, Doull J, editors Casarett and Doull's Toxicology: The Basic Science of Poisons. 6th ed. New York: MacMillan 2001. p. 763"‘810.

Jintana S, Smig K, Krongtong Y, Thanyachai S. Cholinesterase activity, pesticide exposure and health impact in a population exposed to organophosphates. Int Arch Occup Environ Health 2009;82:833"‘42.

Das GP, Jamil K, Rahman MF. Effect of four organophosphorus compounds on human blood acetylcholinestrase: In vitro studies.Toxicol Mech Methods 2006;16:455"‘9.

Simoniello MF, Kleinsorge EC, Scagnetti JA, Grigolato RA, Poletta GL, Carballo MA. DNA damage in workers occupationally exposed to pesticide mixtures. J Appl Toxicol 2008;28:957"‘65.

Mandour RA. Environmental risks of insecticides cholinesterase inhibitors. Toxicol Int 2013;20:30"‘4.

Plianbangchang P, Jetiyanon K, Wittaya"‘Areekul S. Pesticide use patterns among small"‘scale farmers: A case study from Phitsanulok, Thailand. Southeast Asian J Trop Med Public Health 2009;40:401"‘10.

White BJ, Legako JA, Harmon HJ. Extended lifetime of reagentless detector for multiple inhibitor on AChE. Biosens Bioelectron 2003;18:729"‘34.

Kashyap SK, Jani JP, Saiyed HN, Gupta SK. Clinical effects and cholinesterase activity changes in workers exposed to phorate (Thimet). J Environ Sci Health B 1984;19:479"‘89.

Naqvi SN, Azmi MA, Moinuddin, Azmi MA, Aslam M, Perveen R.Effect of pesticide residues on health and enzymes in the blood of farmer workers around Karachi, Pakistan. J Exp Zool India 2007;10:43"‘54.

Ctano HC, Carranza E, Huamani C, Hernandez AF. Plasma cholinesterase levels and health symptoms in Peruvian farm workers exposed to organophosphate pesticides. Arch Environ Contam Toxicol 2008;55:153"‘9.

Kachaiyaphum P, Howteerakul N, Sujirarat D, Siri S, Suwannapong N. Serum cholinesterase levels of thai chilli"‘farm workers exposed to chemical pesticides: Prevalence estimates and associated factors. J Occup Health 2010;52:89"‘98.

Pornpanuwit C. Blood cholinesterase enzyme levels of the farmers using agricultural pesticide in Muang District, Phrae Province. 2009 Available from: http://www.phraehospital.go.th/"‘occmed/PowerPoint/cholinesterate.doc.

Singhaseni P. Pesticides. In: Bovornkitti S, Loftus JP, Srisamran K, editors. Environ Med. Bangkok: Ruean Kaew 1999. p. 505"‘31.

Joshaghani HR, Mansourian AR, Kalavi K, Salimi S. Haematologic indices in pesticide factory workers. J Biol Sci 2007;7:566"‘9.

Cucuianu M, Nistor T, Hancu N, Orbai P, Muscurel C, Stoian I.Serum cholinesterase activity correlates with serum insulin, C"‘peptide and free fatty acids levels in patients with type 2 diabetes. Rom J Intern Med 2002;40:43"‘51.