Preliminary Toxicological Report of Metformin Hydrochloride Loaded Polymeric Nanoparticles

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Authors

  • Unnikrishnan Meenakshi Dhana Lekshmi
     ,IN
  • Pully Neelakanta Reddy
     ,IN

Keywords:

Haemolysis, metformin hydrochloride, polymeric nanoparticles, toxicity

Abstract

Nanosized materials have tremendous application in every field of human activity, with a lot of economic benefit increasing nanoparticle research and use. There are number of nanosized products already available commercially and many others are in queue. Therefore, there is a pressing need for careful consideration of benefits and side effects of the use of nanoparticles in medicine. This research work aims at providing a balanced update of this exciting potentially toxicological effect of manufactured Metformin hydrochloride loaded polymeric nanoparticles. To assess the toxicities systematically on the functions of various tissues and organs in rats, the rats were fed with the manufactured polymeric nanoparticles for a period of 30 days repeated oral administration. Variation in the protein, carbohydrate and fat metabolic profile of the rat exposed to nanoparticles were studied by hematobiochemical and pathology profiles. The haemolytic potential of these nanoparticles were determined by means of an in vitro haemolysis assay. All formulations showed haemolytic effect less than 5%. The study revealed that Metformin loaded PMMA and PLGA polymeric nanoparticle did not produce any toxicity.

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Published

2018-08-14

How to Cite

Lekshmi, U. M. D., & Reddy, P. N. (2018). Preliminary Toxicological Report of Metformin Hydrochloride Loaded Polymeric Nanoparticles. Toxicology International, 19(3), 267–272. Retrieved from https://informaticsjournals.co.in/index.php/toxi/article/view/21759

Issue

Volume 19, Issue 3, September - December 2012

Section

Original Research
Received 2018-08-14
Accepted 2018-08-14
Published 2018-08-14

 

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