Effect of Shodhana Treatment on Chronic Toxicity and Recovery of Aconite

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Authors

  • P. K. Sarkar
     ,IN
  • P. K. Prajapati
     ,IN
  • V. J. Shukla
     ,IN
  • B. Ravishankar
     ,IN

Keywords:

Aconitum chasmanthum, cow's urine, cow's milk, recovery, shodhana

Abstract

Aconite is one of the poisonous plants used therapeutically in practice of Ayurveda after proper treatment called as ‘Shodhana'. To determine the effect of Shodhana treatment on chronic toxicity and to assess the effect of recovery period after chronic toxicity of aconite. Raw aconite (RV), urine treated aconite (SM), and milk treated aconite (SD) were administered in 6.25 mg/kg dose in Charles Foster strain albino rats for 90 days for chronic toxicity. Six rats from each were kept for another 30 days without test drugs treatment to observe recovery from chronic toxicity. RV was found to be highly toxic in chronic exposure, SM had no apparent toxicity, but SD had mild toxicity in kidney. The toxicities of RV and SD were reversible, but sudden withdrawal of SM caused adverse effects, suggestive of tapering withdrawal. Shodhana treatments remove toxic effects from raw aconite. Chronic toxicity of aconite is reversible. Confirmed the arrangement of abstract

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Published

2018-08-21

How to Cite

Sarkar, P. K., Prajapati, P. K., Shukla, V. J., & Ravishankar, B. (2018). Effect of Shodhana Treatment on Chronic Toxicity and Recovery of Aconite. Toxicology International, 19(1), 35–41. Retrieved from https://informaticsjournals.co.in/index.php/toxi/article/view/21842

Issue

Volume 19, Issue 1, January- April 2012

Section

Original Research
Received 2018-08-21
Accepted 2018-08-21
Published 2018-08-21

 

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