Therapeutic Role of Mitochondria Targeted Curcumin against Pseudomonas aeruginosa Induced Oxidative Stress in Thyroid Gland of Female Swiss albino Mice

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Authors

  • Narendra Namdev
     Endocrinology Laboratory, Department of Zoology, School of Biological Sciences, Dr Harisingh Gour University, Sagar – 470003, Madhya Pradesh ,IN
  • Arun Kumar
     Endocrinology Laboratory, Department of Zoology, School of Biological Sciences, Dr Harisingh Gour University, Sagar – 470003, Madhya Pradesh ,IN
  • Gayatri Rai
     Endocrinology Laboratory, Department of Zoology, School of Biological Sciences, Dr Harisingh Gour University, Sagar – 470003, Madhya Pradesh ,IN
  • Payal Mahobiya
     Endocrinology Laboratory, Department of Zoology, School of Biological Sciences, Dr Harisingh Gour University, Sagar – 470003, Madhya Pradesh ,IN

DOI:

https://doi.org/10.18311/ti/2020/v27i1&2/24457

Keywords:

Mitochondria Targeted Curcumin, Pseudomonas aeruginosa, Thyroid Gland, T3, T4, TSH
MIcrobial toxicity and Endocrinology

Abstract

Bacteria are found universally and contaminate the soil, air and water. Through contaminated air, water and soil bacteria reach inside the body and causes immense harm. The problem of thyroid is that, it affects the public health worldwide. The main purpose of this investigation is to find out the toxic effects of Pseudomonas aeruginosa on thyroid gland and preventive role of mitochondria targeted curcumin in bacterial induced thyroid toxicity in female Swiss albino mice. The animals are separated in different groups. Group I served as control and Group II administered with effective dose of Pseudomonas aeruginosa. Group III co-treated with mitochondria targeted curcumin for the period of 14 days. With the completion of treatment period blood serum and tissue samples were collected for determining the level of thyroid hormones and oxidative stress. In this investigation shows that mice exposed to bacteria have decreased T3 and T4 concentration as compared to control and co-treated mice have some elevated level of T3 and T4 hormones as compared to bacteria treated mice. In the biochemical study it is found that the increased lactate dehydrogenate, catalase activity, superoxide dismutase and lipid peroxidation and decreased glutathione reductase points towards the induced oxidative stress in thyroid gland. It is concluded that the exposure to Pseudomonas aeruginosa causes thyroid problem and treatment with mitochondria targeted curcumin prevents the induced toxicity.

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Published

2020-10-01

How to Cite

Namdev, N., Kumar, A., Rai, G., & Mahobiya, P. (2020). Therapeutic Role of Mitochondria Targeted Curcumin against <i>Pseudomonas aeruginosa</i> Induced Oxidative Stress in Thyroid Gland of Female <i>Swiss albino</i> Mice. Toxicology International, 27(1&amp;2), 14–22. https://doi.org/10.18311/ti/2020/v27i1&2/24457

Issue

Volume 27, Issue 1&2, January-June 2020

Section

Research Articles
Crossref
Scopus
Google Scholar
Europe PMC
Received 2019-11-23
Accepted 2020-03-18
Published 2020-10-01

 

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