Rutin a Citrus Flavonoid Attenuates Sodium Arsenate Induced Cytotoxicity in CHO Cells

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Authors

  • S. A. Salmataj
     Department of Biotechnology, MIT, MAHE, Manipal – 576104, Karnataka ,IN
  • Pushpanjali Bhat
     Department of Chemistry, MIT, MAHE, Manipal – 576104, Karnataka ,IN
  • Shobha Kamath
     Department of Biochemistry, KMC, MAHE, Manipal – 576104, Karnataka ,IN

DOI:

https://doi.org/10.18311/ti/2020/v27i3&4/26077

Keywords:

CHO, GSH, GST, SOD, Sodium Arsenate
Toxicology

Abstract

The potential role of oxidative stress in the pathogenesis induced by arsenic proposes that antioxidants can be deliberated as an alternative approach in alleviating arsenic-induced toxicity. The aim of this work was to assay in vitro the potential advantageous effects of plant flavonoid rutin against arsenate exposure, by studying lipid peroxidation and the stress-related markers. Rutin, a flavanol, has been exhibiting anti-cancer property, mitigating, hostile to diabetic and anti-inflammatory properties. CHO cells were selected to study the effect of sodiumarsenate and its amelioration by rutin a citrus flavonoid glycoside. Sodium arsenate at low concentration induced cytotoxicity and genotoxicity. MTT assay, Catalase, Superoxide dismutase, GSH, GST and lipid peroxidation was measured in CHO cell. Pre-treatment of CHO cells with rutin attenuated arsenate induced toxicity. DNA damage was also measured.

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Published

2022-08-12

How to Cite

Salmataj, S. A., Bhat, P., & Kamath, S. (2022). Rutin a Citrus Flavonoid Attenuates Sodium Arsenate Induced Cytotoxicity in CHO Cells. Toxicology International, 27(3&4), 188–192. https://doi.org/10.18311/ti/2020/v27i3&4/26077

Issue

Volume 27, Issue 3&4, July-December 2020

Section

Research Articles
Crossref
Scopus
Google Scholar
Europe PMC
Received 2020-09-16
Accepted 2020-11-29
Published 2022-08-12

 

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