Reversal of Hepato-renal Impairment Induced by Meloxicam Paracetamol Toxicity in a Labrador Dog

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Authors

  • M. Saravanan
     Veterinary Clinical Complex, Veterinary College and Research Institute, TANUVAS, Orathanadu, Thanjavur – 614 625, Tamil Nadu ,IN
  • N. Premalatha
     Department of Veterinary Medicine, Veterinary College and Research Institute, TANUVAS, Orathanadu, Thanjavur – 614 625, Tamil Nadu ,IN
  • P. K. Ramkumar
     Veterinary Clinical Complex, Veterinary College and Research Institute, TANUVAS, Orathanadu, Thanjavur – 614 625, Tamil Nadu ,IN
  • K. Kannan
     Veterinary Clinical Complex, Veterinary College and Research Institute, TANUVAS, Orathanadu, Thanjavur – 614 625, Tamil Nadu ,IN
  • R. Apoorva
     Department of Veterinary Medicine, Veterinary College and Research Institute, TANUVAS, Orathanadu, Thanjavur – 614 625, Tamil Nadu ,IN
  • M. Venkatesan
     Department of Veterinary Medicine, Veterinary College and Research Institute, TANUVAS, Orathanadu, Thanjavur – 614 625, Tamil Nadu ,IN
  • K. Jayalshmi
     Department of Veterinary Medicine, Veterinary College and Research Institute, TANUVAS, Orathanadu, Thanjavur – 614 625, Tamil Nadu ,IN
  • S. Yogeshpriya
     Department of Veterinary Medicine, Veterinary College and Research Institute, TANUVAS, Orathanadu, Thanjavur – 614 625, Tamil Nadu ,IN
  • S. Senthilkumar
     Department of Veterinary Medicine, Veterinary College and Research Institute, TANUVAS, Orathanadu, Thanjavur – 614 625, Tamil Nadu ,IN

DOI:

https://doi.org/10.18311/ti/2021/v28i1/26394

Keywords:

Dog, Hepatotoxicity, Hyperbilirubinemia, Meloxicam, Paracetamol
Small animals drug toxicity

Abstract

An 8 years old male Labrador dog was referred to Small animal Medicine Referral Clinic, Veterinary Clinical complex, Veterinary College and Research Institute, Orathanadu for fever, anorexia, hematemesis and melenic stools. The dog on treatment with 2 ml of Meloxicam Paracetamol combination IM, along with Injection Oxytetracycline and fluid therapy for 3 days by locally and did not respond to treatment thus was referred. Clinical dullness, lethargy, respiratory distress, visible mucosal jaundice, ecchymosis on ventral abdomen was noticed. Physical examination revealed, halitosis, ulceration in the tip of the tongue, dehydration, pre scapular LN enlargement, distended abdomen, fluid thrill and splenomegaly. Hematology revealed anemia and thrombocytopenia. Biochemical analysis revealed Hyperbilirubinemia, Elevated BUN, Creatinine, AST, ALT, ALP and hypoalbuminemia. Abdominal ultrasound reveled splenomegaly, focal hyperechoic liver parenchyma, cortex echogenicity of right kidney and perirenal fluid accumulation. ECG revealed peaked T wave. Radiography revealed hepatosplenomegaly. Hemato-biochemical alteration was monitored before and after therapy. Animal was managed with fluid therapy, Acetylcysteine, Amino acid and supportives and the dog had an uneventful recovery.

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Published

2021-03-24

How to Cite

Saravanan, M., Premalatha, N., Ramkumar, P. K., Kannan, K., Apoorva, R., Venkatesan, M., Jayalshmi, K., Yogeshpriya, S., & Senthilkumar, S. (2021). Reversal of Hepato-renal Impairment Induced by Meloxicam Paracetamol Toxicity in a Labrador Dog. Toxicology International, 28(1), 81–89. https://doi.org/10.18311/ti/2021/v28i1/26394

Issue

Volume 28, Issue 1, January-March 2021

Section

Original Research
Crossref
Scopus
Google Scholar
Europe PMC
Received 2020-11-17
Accepted 2021-01-06
Published 2021-03-24

 

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