Appraisal of Trace Elements and Heavy Metals Levels in Breast Cancer Patients of Basrah Province

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Authors

  • Eman Abdulhaleem Khalaf
     Department of Biology, Faculty of Science, University of Basrah, Basrah ,IQ
  • Salwa A. Abduljaleel
     Department of Biology, Faculty of Science, University of Basrah, Basrah ,IQ
  • Hadeel Majid Al-Jassani
     Al-Sader Hospital, Center of Oncology, Basrah ,IQ

DOI:

https://doi.org/10.18311/ti/2021/v28i2/26484

Keywords:

Breast Cancer, Levels, Patient, Toxic Metals
toxicology

Abstract

We know that metals are linked to a number of health problems such as constipation, abdominal pain, according to previous reports and lack of appetite, sickness, wakefulness, annoyance, irascibility, giddiness and encephalopathy. However, recent studies have found correlation between cancer and some toxic metals concentration in patients body. Most carcinogegenic metals are Cd, Pb and Hg. Objective: Current study was aimed to determine the concentrations of some metals(Cd, Pb, Hg, Cr, Cu and Zn) in whole blood, serum and hair of breast cancer patients in Basrah city, South of Iraq. Methods: Sample of whole blood, serum and hair were obtained from 60 breast cancer patients, the same samples were collected from 25 people without cancer as control group. Concentrations of heavy metals were carried out using ICP MS (an inductively coupled plasma atomic absorption spectrophotometer). Results: Concentrations of toxic metal such as Cd and Hg occurred at low level in three tissues while Zn occurred at higher concentrations. Pb concentration in the whole blood sample was 22.36 ug/l, Cr: 6.63, cu: 42.35.ug/g, serum of patients accumulating higher concentrations of Hg, Cr, Cu and Cd than in the whole blood sample. Even as Pb and Zn concentrations were high in whole blood. Conversely, hair sample of breast cancer patient accumulated significantly higher concentrations of Hg. Cr, Cu, Cd, Pb and Zn compared to other tissues. Positive correlations were recorded between Cd and Pb (r = 0.46), Zn with Cr, Cu and Hg (r = 0.78, 0.56, 0.88) respectively. Conclusion: High concentrations of Hg, Cr, Cu, Cd and Pb were detected in whole blood, serum and hair of breast cancer patients relative with other control group. Hair samples accumulated the high levels of Cd, Cu, Cr, Hg, Pb and Zn in comparison with whole blood and serum of breast cancer patients.

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Published

2021-05-31

How to Cite

Abdulhaleem Khalaf, E., Abduljaleel, S. A., & Majid Al-Jassani, H. (2021). Appraisal of Trace Elements and Heavy Metals Levels in Breast Cancer Patients of Basrah Province. Toxicology International, 28(2), 127–134. https://doi.org/10.18311/ti/2021/v28i2/26484

Issue

Volume 28, Issue 2, April-June 2021

Section

Original Research
Crossref
Scopus
Google Scholar
Europe PMC
Received 2020-12-02
Accepted 2021-02-01
Published 2021-05-31

 

References

Jan AT, Azam M, Siddiqui K, et al. Heavy metals and human health: Mechanistic insight into toxicity and counter defense system of antioxidants. Interna J of Molec Scie. 2015; 16(12):29592–630. PMid: 26690422 PMCid: PMC4691126. https://doi.org/10.3390/ijms16 1226183 DOI: https://doi.org/10.3390/ijms161226183

Peplow D. Environmental impacts of Hardrock Mining in Eastern Washington. University of Washington Fact Sheet. 2000; 8.

Jose A, Cherian G, Ray JG. Amalgam practicing style and other related variables on blood mercury levels of dentists in Kerala. India KDJ. 2017; 40(3):201–4.

Islam MS, Ahmed MK, Raknuzzaman M, Habibullahal- Mamun M, Islam MK. Heavy metal pollution in surface water and sediment: A preliminary assessment of an urban river in a developing country. Ecolo Indicat. 2015; 48:282–91. https://doi.org/10.1016/j. ecolind.2014.08.016 DOI: https://doi.org/10.1016/j.ecolind.2014.08.016

Fukuda H, Masaaki E, Hiroyuki Y, Manaka A, Shinichiro O, Masamichi O, Masaharu Y, Nobuyuki S, Hiromitsu S. Trace elements and cancer. J Japan Medi Asso. 2003; 129(5):646–8.

Cobanoglu U, Demir H, Sayir F, et al. Some mineral, trace element and heavy metal concentrations in lung cancer. Asi Pacific J Cancer Prev. 2010; 11(5):1383–8.

Cavusoglu K, Cakir AS, Kurtman C, et al. The determination of alteration in plasma trace element levels of patients with lung cancer received radiotherapy. Firat University Medical. J Health Sci. 2008; 22(4):211–22.

Zhang R, Ma A, Urbanski SJ, McCafferty D. Induction of inducible nitric oxide synthase: A protective mechanism in colitis-induced adenocarcinoma. Carcinogenesis. 2007; 28:1122–30. PMid: 17116728. https://doi.org/10.1093/carcin/bgl224 DOI: https://doi.org/10.1093/carcin/bgl224

Huff J, Lunn RM, Waalkes MP, Tomatis L, Infante PF. Cadmium-induced cancers in animals and in humans. Int J Occup Environ Health. 2007; 13:202–12. PMid: 17718178 PMCid: PMC3399253. https://doi. org/10.1179/oeh.2007.13.2.202 DOI: https://doi.org/10.1179/oeh.2007.13.2.202

Jawad Al-Ali. Epidemiological study on increase of cancer in Basrah region, dr. director of the Cancer Center, Sadr teaching hospital, Basrah, Iraq. 2003.

Khudhair AY. Determination of trace metals in hair samples of Iraqis people living in suburban and urban in Basrah governate, Southern of Iraq.Thi-Qar J Sci. 2014; 4(3):58–67.

Weiam A, Sawsan K, Al atrakchi A. Study on trace element concentration in hair, blood and urine of roadways cleaners workers in Kerbala city. Kerbala J Pharma Sci. 2012; 3:77–85.

Momodu MA, Anyakora CA. Heavy metal contamination of ground water. The Surulere case study. Res J of Environ Earth Sci. 2010; 2:39–43.

Lappano R, Malaguarnera R, Belfiore A, Maggiolini M. Recent advances on the stimulatory effects of metals in breast cancer. Mol Cell Endocrinol. 2017; 457:49–56. PMid: 27765682. https://doi.org/10.1016/j. mce.2016.10.017 DOI: https://doi.org/10.1016/j.mce.2016.10.017

Melchior M, Goldberg M, Krieger N, Kawachi I, Menvielle G, Zins M, et al. Occupational class, occupational mobility and cancer incidence among middle-aged men and women: A prospective study of the French GAZEL Cohort. Can Caus Contr. 200516:515–24. PMid: 15986106. https://doi.org/10.1 007/s10552-004-7116-0

Carlsen K, Hoybye MT, Dalton SO, Tjonnel and A. Social inequality and incidence of and survival from breast cancer in a population-based study in Denmark, 1994-2003. Eur J Cancer. 2008; 44:1996–2002. PMid: 18701275. https://doi.org/10.1016/j.ejca.2008.06.027 DOI: https://doi.org/10.1016/j.ejca.2008.06.027

Kvikstad A, Vatten LJ, Tretli S, Kvinnsl and S. Death of a husband or marital divorce related to risk of breast cancer in middle-aged women. A nested case-control study among Norwegian women born 1935-1954. Eur J Cancer. 1994; 30:473–7. https://doi.org/10.1016/0959- 8049(94)90422-7 DOI: https://doi.org/10.1016/0959-8049(94)90422-7

Antila E, Mussalo-Rauhamaa H, Kantola M, Atroshi F, Westermarck T. Association of cadmium with human breast cancer. Sci Total Environ. 1996; 186:251–6. https://doi.org/10.1016/0048-9697(96)05119-4 DOI: https://doi.org/10.1016/0048-9697(96)05119-4

Menglin et al. Does marital status correlate with the female breast cancer risk? A systematic review and meta-analysis of observational studies. PLoS One. 2020; 15(3):e0229899. PMid: 32134997 PMCid: PMC7058335. https://doi.org/10.1371/journal.pone.0 229899 DOI: https://doi.org/10.1371/journal.pone.0229899

Freeland-Graves JH, Sanjeevi N, Lee JJ. Global perspectives on trace element requirements. J Trace Elem Medi Biol. 2015; 31:135–41. PMid: 24912973. https://doi.org/10.1016/j.jtemb.2014.04.006 DOI: https://doi.org/10.1016/j.jtemb.2014.04.006

Choi R, Min-Ji Kim, Insuk Sohn, Serim Kim, Isaac Kim, Jai Min Ryu, Hee Jun Choi Jae-Myung Kim, Se Kyung Lee, Jonghan Yu, Seok Won Kim, Seok Jin Nam, Jeong Eon Lee, Soo-Youn Lee. Serum trace elements and their associations with breast cancer subgroups in Korean breast cancer patients. Nutrients. 2019; 11: 37. PMid: 30586919 PMCid: PMC6357144. https://doi. org/10.3390/nu11010037 DOI: https://doi.org/10.3390/nu11010037

Wu X, Tang J, Xie M. Serum and hair zinc levels in breast cancer: A meta-analysis. Sci Rep 2015; 5:12249. PMid: 26179508 PMCid: PMC4503961. https://doi. org/10.1038/srep12249 DOI: https://doi.org/10.1038/srep12249

Ding X, Jiang M, Jing H, Sheng W, Wang X, Han J, Wang L. Analysis of serum levels of 15 trace elements in breast cancer patients in Shandong, China. Environ Sci Pollu Rese. 2015; 22:7930–5. PMid: 25520207. https://doi.org/10.1007/s11356-014-3970-9 DOI: https://doi.org/10.1007/s11356-014-3970-9

Wu HD, Chou SY, Chen DR, Kuo HW. Differentiation of serum levels of trace elements in normal and malignant breast patients. Biolo Trace Elem Resea. 2006; 113:9–18. https://doi.org/10.1385/BTER:113:1:9 DOI: https://doi.org/10.1385/BTER:113:1:9

Alatise OI, Schrauzer GN. Lead exposure: A contributing cause of the current breast cancer epidemic in Nigerian women. Biolo Trace Elem Resea. 2010; 136:127–39. PMid: 20195925 PMCid: PMC2883097. https://doi.org/10.1007/s12011-010-86 08-2 DOI: https://doi.org/10.1007/s12011-010-8608-2

Kotsopoulos J, Sukiennicki G, Muszynska M, Gackowski D, Kaklewski K, Durda K, Jaworska K, Huzarski T, Gronwald J, Byrski T, et al. Plasma micronutrients, trace elements and breast cancer in brca1 mutation carriers: An exploratory study. Can Caus Cont. 2012; 23:1065–74. PMid: 22576580. https://doi.org/10.1007/s10552-012-9975-0 DOI: https://doi.org/10.1007/s10552-012-9975-0

Feng JF, Lu L, Zeng P, Yang YH, Luo J, Yang YW, Wang D. Serum total oxidant/antioxidant status and trace element levels in breast cancer patients. Interna J Clini Oncol. 2012; 17:575–83. PMid: 21968912. https://doi. org/10.1007/s10147-011-0327-y DOI: https://doi.org/10.1007/s10147-011-0327-y

Pavithra V, Sathisha TG, Kasturi K, Mallika DS, Amos SJ, Ragunatha S. Serum levels of metal ions in female patients with breast cancer. J Clin Diagn Resea. 2015; 9:BC25–7. PMid: 25737978 PMCid: PMC4347069. https://doi.org/10.7860/JCDR/2015/11627.5476 DOI: https://doi.org/10.7860/JCDR/2015/11627.5476

Adeoti ML, Oguntola AS, Akanni EO, Agodirin OS, Oyeyemi GM. Trace elements; copper, zinc and selenium in breast cancer afflicted female patients in LAUTECHO sogbo, Nigeria. Indi J Cancer. 2015; 52:106–9. PMid: 26837992. https://doi. org/10.4103/0019-509X.175573 DOI: https://doi.org/10.4103/0019-509X.175573

Saleh F, Behbehani A, Asfar S, Khan I, Ibrahim G. Abnormal blood levels of trace elements and metals, DNA damage and breast cancer in the state of Kuwait. Biolo Trace Elem Res. 2011; 141:96–109. PMid: 20495889. https://doi.org/10.1007/s12011-010-8724-z DOI: https://doi.org/10.1007/s12011-010-8724-z

El-Harouny MA, Doaa A, Basel RA, Hend M. Chronic toxicity of some heavy metals and breast cancer in Egyptian Females. J of Clin Toxico. 2011; 1(2):2–4.

Jouybari L, Marzieh SG, Akram S, Faezeh K, Fatemeh S, Kourosh S, Ali HD. Toxic elements as biomarkers for breast cancer. A meta-analy study. 2018; 10:69–79. PMid: 29391828 PMCid: PMC5768192. https://doi. org/10.2147/CMAR.S151324 DOI: https://doi.org/10.2147/CMAR.S151324