Genotoxicity of Beta-Sitosterol, Betulinic Acid, Biochanin A, and Ursolic Acid, Potential Anthelmintic Phyto-Compounds

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Authors

  • Vijaya Mishra
     Department of Zoology, North-Eastern Hill University, Shillong – 793022, Meghalaya ,IN
  • Arun K. Yadav
     Department of Zoology, North-Eastern Hill University, Shillong – 793022, Meghalaya ,IN
  • Amar Deep Soren
     PG and Research Department of Zoology, B. Borooah College, Guwahati – 781007, Assam ,IN

DOI:

https://doi.org/10.18311/ti/2023/v30i2/30946

Keywords:

Beta Sitosterol, Betulinic Acid, Biochanin A, Genotoxicity, Ursolic Acid
Genotoxicity

Abstract

Beta-sitosterol, betulinic acid, biochanin A and ursolic acid are known to possess anthelmintic properties. This study was undertaken to assess the genotoxic potentials of these phytocompounds in albino rats. Animals were orally administered with 1 and 10 mg/ml of the above phyto-compounds for a period of 14 days. All the animals were subjected to mitotic arrest before sacrifice and then bone marrow cells were collected from both the femurs and processed to observe the chromosomal aberrations. The results revealed that ursolic acid induced the maximum number of statistically significant abnormalities (p ≤ 0.05) followed by betulinic acid and biochanin A. Beta-sitosterol was found to be the safest of all the tested phytocompounds as far as chromosomal abnormalities in short term oral studies are concerned as it did not lead to major changes at genomic level. Although these phyto-compounds are considered potential anthelmintics, their long-term use may cause genotoxic effects to the users.

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Published

2023-05-19

How to Cite

Mishra, V., Yadav, A. K., & Soren, A. D. (2023). Genotoxicity of Beta-Sitosterol, Betulinic Acid, Biochanin A, and Ursolic Acid, Potential Anthelmintic Phyto-Compounds. Toxicology International, 30(2), 155–160. https://doi.org/10.18311/ti/2023/v30i2/30946

Issue

Volume 30, Issue 2, April-June 2023

Section

Articles
Crossref
Scopus
Google Scholar
Europe PMC
Received 2022-08-11
Accepted 2023-01-25
Published 2023-05-19

 

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