Safety Evaluation of Arsenicum album in Acute and Sub-Acute Toxicity Studies in Rats

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Authors

  • Roshan Lal
     Department of Pharmacology, Dr. D. P. Rastogi, Central Council for Research in Homoeopathy, Noida - 201301, Uttar Pradesh ,IN
  • Mahima Sharma
     Department of Pharmacology, Dr. D. P. Rastogi, Central Council for Research in Homoeopathy, Noida - 201301, Uttar Pradesh ,IN
  • Sangita Behera
     Department of Pharmacology, Dr. D. P. Rastogi, Central Council for Research in Homoeopathy, Noida - 201301, Uttar Pradesh ,IN
  • Raj Kumar Regar
     Department of Pharmacology, Dr. D. P. Rastogi, Central Council for Research in Homoeopathy, Noida - 201301, Uttar Pradesh ,IN
  • Deepika Tripathi
     Department of Pharmacology, Dr. D. P. Rastogi, Central Council for Research in Homoeopathy, Noida - 201301, Uttar Pradesh ,IN
  • G. V. Narasimha Kumar
     Dr Anjali Chatterji Regional Research Institute for Homoeopathy, Kolkata - 700035, West Bengal ,IN
  • Satvinder Singh
     Department of Pharmacology, Dr. D. P. Rastogi, Central Council for Research in Homoeopathy, Noida - 201301, Uttar Pradesh ,IN
  • Digvijay Verma
     Central Council for Research in Homoeopathy, New Delhi - 110023 ,IN
  • Pankaj Gupta
     Department of Pharmacology, Dr. D. P. Rastogi, Central Council for Research in Homoeopathy, Noida - 201301, Uttar Pradesh ,IN
  • Subhash Kaushik
     Central Council for Research in Homoeopathy, New Delhi - 110023 ,IN
  • Anil Khurana
     Central Council for Research in Homoeopathy, New Delhi - 110023 ,IN

DOI:

https://doi.org/10.18311/ti/2023/v30i2/32299

Keywords:

Complementary and Alternative Medicines, Homoeopathy, Safety, Toxicity

Abstract

Arsenic album is frequently prescribed in homoeopathy for many diseases. However, its safety data is not available. Thus, the study’s purpose is to evaluate the oral toxicity of Arsenic album 6C, 30C, and 200C in rats. Arsenic album (6C, 30C, and 200C) was given at 2000 μl/kg for acute toxicity and observed for up to 14 days. For subacute toxicity, it was given for 28 days and observed for clinical signs, change in body weight and Mortality. Hematological, biochemical, organ weight and histopathological analyses were assessed. Results indicate no mortality of arsenic album in acute toxicity and LD50 is >2000 μl/kg. In the subacute toxicity study, arsenic album (200 μl/kg) did not show any significant changes in above parameters. It may be concluded that the arsenic album (6C, 30C, and 200C) is safe and produces no toxicity when administered orally for a prolonged duration at 200 μl/kg in rats.

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Published

2023-05-23

How to Cite

Lal, R., Sharma, M., Behera, S., Regar, R. K., Tripathi, D., Kumar, G. V. N., Singh, S., Verma, D., Gupta, P., Kaushik, S., & Khurana, A. (2023). Safety Evaluation of Arsenicum album in Acute and Sub-Acute Toxicity Studies in Rats. Toxicology International, 30(2), 233–247. https://doi.org/10.18311/ti/2023/v30i2/32299

Issue

Volume 30, Issue 2, April-June 2023

Section

Articles
Crossref
Scopus
Google Scholar
Europe PMC
Received 2023-01-04
Accepted 2023-02-16
Published 2023-05-23

 

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