Disposition Kinetics and Tissue Distribution of Titanium Dioxide (TiO2) Nanoparticles Following Single Exposure in Male Wistar Rats

Jump To References Section

Authors

  • G. R. Shivaprasad
     Department of Veterinary Pharmacology and Toxicology, Karnataka Veterinary, Animal and Fisheries Sciences University, Veterinary College, Hebbal, Bengaluru - 560024 ,IN
  • Nadoor Prakash
     Department of Veterinary Pharmacology and Toxicology, Karnataka Veterinary, Animal and Fisheries Sciences University, Veterinary College, Bidar - 585226, Karnataka ,IN
  • Prashant Kumar Waghe
     Department of Veterinary Pharmacology and Toxicology, Karnataka Veterinary, Animal and Fisheries Sciences University, Veterinary College, Bidar - 585226, Karnataka ,IN
  • B. H. Pavithra
     Department of Veterinary Pharmacology and Toxicology, Karnataka Veterinary, Animal and Fisheries Sciences University, Veterinary College, Hebbal, Bengaluru - 560024, Karnataka ,IN
  • C. R. Santhosh
     Department of Veterinary Pharmacology and Toxicology, Karnataka Veterinary, Animal and Fisheries Sciences University, Veterinary College, Gadag - 582102, Karnataka ,IN
  • Rashmi Rajashekaraiah
     Department of Veterinary Pharmacology and Toxicology, Karnataka Veterinary, Animal and Fisheries Sciences University, Veterinary College, Hebbal, Bengaluru - 560024, Karnataka ,IN
  • Y. Muralidhar
     Department of Veterinary Pharmacology and Toxicology, Karnataka Veterinary, Animal and Fisheries Sciences University, Veterinary College, Hebbal, Bengaluru - 560024, Karnataka ,IN
  • T. N. V. K. V. Prasad
     Nanotechnology Laboratory Regional Agricultural Research Station, ANGRAU, Tirupati - 517502, Andhra Pradesh ,IN
  • U. Sunilchandra
     Department of Veterinary Pharmacology and Toxicology, Karnataka Veterinary, Animal and Fisheries Sciences University, Veterinary College, Shivamogga - 577204, Karnataka ,IN
  • M. Vijaykumar
     Department of Veterinary Pharmacology and Toxicology, Karnataka Veterinary, Animal and Fisheries Sciences University, Veterinary College, Bidar - 585226, Karnataka ,IN
  • S. S. Manjunath
     Department of Veterinary Pathology, Karnataka Veterinary, Animal and Fisheries Sciences University, Veterinary College, Shivamogga - 577204, Karnataka ,IN
  • K. Vaibhavi
     Department of Veterinary Pharmacology and Toxicology, Karnataka Veterinary, Animal and Fisheries Sciences University, Veterinary College, Hebbal, Bengaluru - 560024, Karnataka ,IN

DOI:

https://doi.org/10.18311/ti/2024/v31i1/34886

Keywords:

Nanoparticles, Toxicokinetics, Titanium Dioxide (TiO2), Wistar Rats

Abstract

Titanium Dioxide (TiO2) nanoparticles are one among the several environmental contaminants essentially due to their widespread applications in food, medicine, cosmetics, electronics, and several other applications. The current experimental study was undertaken to determine the toxicokinetic variables and tissue distribution profile of titanium (Ti) following single intraperitoneal (i.p) administration of titanium dioxide nanoparticles (TiO2 NPs) in male Wistar rats. The Tmax(obs.), Cmax (obs.), the elimination half-life (t1/2k10), the area under the curve (AUC0-336), and AUC0-∞ of TiO2 following single i.p administration of TiO2 NPs in whole blood was 0.5h, 0.26 ± 0.03 μg.ml-l, 486.31 ± 39.66 h, 48.81 ± 0.54 μg/ml*h and 128.28 ± 7.17 μg/ml*h, respectively. The mean Titanium (Ti) concentration ratio for tissue(s)- to whole blood measured at 336 h as well as the Cmax(obs.) was in the order of liver > spleen > lung > kidney > testis > brain following single i.p administration. The elimination half-life (t1/2k10) was in the order of spleen > kidney > liver > lung. The toxicokinetic and tissue distribution profile TiO2 NPs thus derived would serve as baseline data to execute long-term studies with toxicoepidemiological relevant concentration so as to re-visit safety pharmacology governing TiO2 -nanoparticles exposure from various sources including pharmaceuticals.

Downloads

Download data is not yet available.

Downloads

Published

2024-02-28

How to Cite

Shivaprasad, G. R., Prakash, N., Waghe, P. K., Pavithra, B. H., Santhosh, C. R., Rajashekaraiah, R., Muralidhar, Y., Prasad, T. N. V. K. V., Sunilchandra, U., Vijaykumar, M., Manjunath, S. S., & Vaibhavi, K. (2024). Disposition Kinetics and Tissue Distribution of Titanium Dioxide (TiO<sub>2</Sub>) Nanoparticles Following Single Exposure in Male Wistar Rats. Toxicology International, 31(1), 73–81. https://doi.org/10.18311/ti/2024/v31i1/34886

Issue

Volume 31, Issue 1, January-March 2024

Section

Articles

License

Copyright (c) 2024 G. R. Shivaprasad, Nadoor Prakash, Prashant Kumar Waghe, B. H. Pavithra, C. R. Santhosh, Rashmi Rajashekaraiah, Y. Muralidhar, T. N. V. K. V. Prasad, U. Sunilchandra, M. Vijaykumar, S. S. Manjunath, K. Vaibhavi

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Crossref
Scopus
Google Scholar
Europe PMC
Received 2023-08-28
Accepted 2023-12-26
Published 2024-02-28

 

References

Zhao J, Castranova V. Toxicology of nanomaterials used in nanomedicine. J Toxicol Environ Health B Crit Rev. 2011; 14(8):593-632. PMID: 22008094. https://doi.org/10.1080/1 0937404.2011.615113 DOI: https://doi.org/10.1080/10937404.2011.615113

Iavicoli I, Leso V, Bergamaschi. A toxicological effects of titanium dioxide nanoparticles: A review of in-vivo studies. J Nanomater. 2012. PMiD 964381. https://doi. org/10.1155/2012/964381 DOI: https://doi.org/10.1155/2012/964381

Shi H, Magaye R, Castranova V, Zhao J. Titanium dioxide nanoparticles: A review of current toxicological data. Part Fibre Toxicol. 2013; 10:15. PMID: 23587290. https://doi. org/10.1186/1743-8977-10-15 DOI: https://doi.org/10.1186/1743-8977-10-15

Baan R, Straif K, Grosse Y, Secretan B, El Ghissassi F, Cogliano V. Carcinogenicity of carbon black, titanium dioxide, and talc. Lancet Oncol. 2006; 7(4):295-6. PMID: 16598890. https://doi.org/10.1016/S1470-2045(06)70651-9 DOI: https://doi.org/10.1016/S1470-2045(06)70651-9

Weir A, Westerhoff P, Fabricius L, Hristovski K, Von Goetz N. Titanium dioxide nanoparticles in food and personal care products. Environ Sci Technol. 2012; 46(4):2242-50. PMID: 22260395. https://doi.org/10.1021/es204168d DOI: https://doi.org/10.1021/es204168d

Winkler HC, Notter T, Meyer U, Naegeli H. Critical review of the safety assessment of titanium dioxide additives in food. J Nanobiotechnology. 2018; 16(1):51. PMID: 29859103. https://doi.org/10.1186/s12951-018-0376-8 DOI: https://doi.org/10.1186/s12951-018-0376-8

Song Y, Li X, Du X. Exposure to nanoparticles is related to pleural effusion, pulmonary fibrosis, and granuloma. Eur Respir J. 2009; 34(3):559-67. PMID: 19696157. https://doi. org/10.1183/09031936.00178308 DOI: https://doi.org/10.1183/09031936.00178308

Shabbir S, Kulyar MF, Bhutta ZA, Boruah P, Asif M. Toxicological consequences of titanium dioxide nanoparticles (TiO2NPs) and their Jeopardy to the human population. Bionanoscience. 2021; 11(2):621-32. PMID: 33520589. https://doi.org/10.1007/s12668-021-00836-3 DOI: https://doi.org/10.1007/s12668-021-00836-3

Rashid MM, Forte Tavcer P, Tomsic B. Influence of titanium dioxide nanoparticles on human health and the environment. Nanomater (Basel). 2021; 11(9):2354. PMID: 34578667. https://doi.org/10.3390/nano11092354 DOI: https://doi.org/10.3390/nano11092354

Zhang X, Yin L, Tang M, Pu Y. Optimized method for preparation of TiO2 nanoparticles dispersion for biological study. J Nanosci Nanotechnol. 2010; 10(8):5213-9. PMID: 21125873. https://doi.org/10.1166/jnn.2010.2397 DOI: https://doi.org/10.1166/jnn.2010.2397

Golasik M, Herman M, Olbert M, Librowski T, Szklarzewicz J, Piekoszewski W. Toxicokinetics and tissue distribution of titanium in ionic form after intravenous and oral administration. Toxicol Lett. 2016; 247:56-61. PMID: 26892718. https://doi.org/10.1016/j.toxlet.2016.02.009 DOI: https://doi.org/10.1016/j.toxlet.2016.02.009

Elgrabli D, Beaudouin R, Jbilou N, Floriani M, Pery A, Rogerieux F, Lacroix G. Biodistribution and clearance of TiO2 nanoparticles in Rats after intravenous injection. PLoS One. 2015; 10(4):e0124490. PMID: 25909957. https:// doi.org/10.1371/journal.pone.0124490 DOI: https://doi.org/10.1371/journal.pone.0124490

Greenblatt DJ, Abernethy DR, Divoll M. Is the volume of distribution at steady state a meaningful kinetic variable? J Clin Pharmacol. 1983; 23(8-9):391-400. PMID: 6355205. https://doi.org/10.1002/j.1552-4604.1983.tb02753.x DOI: https://doi.org/10.1002/j.1552-4604.1983.tb02753.x

Xie G, Wang C, Sun J, Zhong G. Tissue distribution and excretion of intravenously administered titanium dioxide nanoparticles. Toxicol Lett. 2011; 205(1):55-61. PMID: 21600967. https://doi.org/10.1016/j.toxlet.2011.04.034 DOI: https://doi.org/10.1016/j.toxlet.2011.04.034

Geraets L, Oomen AG, Krystek P, Jacobsen NR, Wallin H, Laurentie M, Verharen HW, Brandon EF, de Jong WH. Tissue distribution and elimination after oral and intravenous administration of different titanium dioxide nanoparticles in rats. Part Fibre Toxicol. 2014; 11:30. PMID: 24993397. https://doi.org/10.1186/1743-8977- 11-30 DOI: https://doi.org/10.1186/1743-8977-11-30

Disdier C, Devoy J, Cosnefroy A, Chalansonnet M, Herlin-Boime N, Brun E, Lund A, Mabondzo A. Tissue biodistribution of intravenously administrated titanium dioxide nanoparticles revealed blood-brain barrier clearance and brain inflammation in the rat. Part Fibre Toxicol. 2015; 12:27. PMID: 26337446. https://doi. org/10.1186/s12989-015-0102-8 DOI: https://doi.org/10.1186/s12989-015-0102-8

Most read articles by the same author(s)