The Effect of Tinospora cordifolia Leaf and Stem Aqueous Extracts on Zidovudine (ZDV) Induced Hematological Changes in Rat Model

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Authors

  • Harinatha Reddy Aswarthagari
     Department of Microbiology, Sri Krishnadevaraya University, Anantapur – 515 003, Andhra Pradesh ,IN
  • Nageswari Gurajala
     Department of Microbiology, Sri Krishnadevaraya University, Anantapur – 515 003, Andhra Pradesh ,IN
  • Srinivasulu Cheemanapalli
     Survey of medicinal plants unit, Regional Ayurveda research institute, Itanagar – 791111, Arunachal Pradesh ,IN
  • Suresh Yarrappagaari
     Division of Ethnopharmacology, Department of Biotechnology, School of Herbal Studies and Naturo Sciences, Dravidian University, Kuppam – 517 426, Andhra Pradesh ,IN
  • Venkatappa Bada
     Department of Microbiology, Sri Krishnadevaraya University, Anantapur – 515 003, Andhra Pradesh, India ,IN

DOI:

https://doi.org/10.18311/ti/2024/v31i3/35516

Keywords:

Immunotoxicity, Spleen and Haematology, Tinospora cordifolia, Zidovudine

Abstract

The present study aims to evaluate the protective role of aqueous extracts of stem and leaves of Tinospora cordifolia (AELTC and AESTC) on the hematologic toxicity effects of ZDV in Rats. A Soxhlet extractor was used to prepare separate aqueous extracts of stem and leaf. Twenty-four albino rats (weighing 200-230 g) were separated into four groups. Group I rats were administered distilled water (negative control). Group II rats were administered 500 mg/kg b.w of ZDV (positive control), Group III rats were administered 500 mg/kg b.w. of AELTC along with ZDV, and Group IV rats were administered 500 mg/kg b.w of AESTC along with ZDV. The hematological parameters of the rats were assayed during the 2nd, 4th, 6th, and 8th weeks of treatment. The animals exposed to Zidovudine showed a significant decrease in Red Blood Cells (RBC), Hemoglobin (Hb), White Blood Count (WBC), and platelet count compared to control (Group I). The results of T. cordifolia leaf and stem administered rats showed a significant elevation in RBC, Hb, WBC, and platelets count. Spleen histology showed immunological and hemorrhagic changes with an accumulation of RBCs and severe depletion of lymphocytes in white pulp were observed in ZDV-treated rats. The intake of AELTC and AESTC showed apparent changes in Spleen tissues. These results suggest that AELTC and AESTC stimulate the hematopoietic system, thereby increasing blood cell levels in ZDV-treated rats.

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Published

2024-05-16

How to Cite

Aswarthagari, H. R., Gurajala, N., Cheemanapalli, S., Yarrappagaari, S., & Bada, V. (2024). The Effect of <i>Tinospora cordifolia</i> Leaf and Stem Aqueous Extracts on Zidovudine (ZDV) Induced Hematological Changes in Rat Model. Toxicology International, 31(3), 371–377. https://doi.org/10.18311/ti/2024/v31i3/35516

Issue

Volume 31, Issue 3, July-September 2024

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Articles

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Copyright (c) 2024 Harinatha Reddy Aswarthagari, Nageswari Gurajala, Srinivasulu Cheemanapalli, Suresh Yarrappagaari, Venkatappa Bada

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

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Received 2023-11-01
Accepted 2024-04-30
Published 2024-05-16

 

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