Mangosteen Peel Extract (Garcinia mangostana L.) and its Constituents to Lower Lipid Content on Adipogenesis Cells Model (3T3-L1)

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Authors

  • Wahyu Widowati
     Faculty of Medicine, Maranatha Christian University, Bandung - 40164 ,ID
  • Lusiana Darsono
     Faculty of Medicine, Maranatha Christian University, Bandung - 40164 ,ID
  • Jo Suherman
     Faculty of Medicine, Maranatha Christian University, Bandung - 40164 ,ID
  • Ervi Afifah
     Biomolecular and Biomedical Research Center, Aretha Medika Utama, Bandung - 40163 ,ID
  • Rizal Rizal
     Biomolecular and Biomedical Research Center, Aretha Medika Utama, Bandung - 40163 ,ID
  • Yukko Arinta
     Biomolecular and Biomedical Research Center, Aretha Medika Utama, Bandung - 40163 ,ID
  • Rismawati Laila Qodariah
     Biomolecular and Biomedical Research Center, Aretha Medika Utama, Bandung - 40163 ,ID
  • Tjandrawati Mozef
     Research Center for Chemistry, Indonesian Institute of Sciences, Bandung, West Java ,ID
  • Tri Suciati
     Faculty of Pharmacy, Bandung Institute of Technology, Bandung, West Java ,ID

DOI:

https://doi.org/10.18311/jnr/2018/18654

Keywords:

Glucose-6-Phosphate Dehydrogenase, Mangosteen, Obesity, Xanthones, 3T3-L1 Cells.
Pharmacotherapy

Abstract

Obesity is one of the risk factor for dyslipidemia incident, cancer, diabetes mellitus, and cardiovascular disease. Treatment of obesity using common commercial drugs shows low rate of success, hence natural products may provide better or more efficient therapeutic approach. Mangosteen (Garcinia mangostana L.) (Clusiaceae) peel extract contains xanthones and it is potentially used as alternative medicine for obesity. This research was done to determine the anti-obesity characteristics of Mangosteen Peel Extract (MPE) and its xanthones α-Mangostin (AM) and γ-Mangostin (GM) on 3T3L1 cell line. Anti-obesity effects of MPE and xanthones were investigated using differentiated-3T3L1 preadipocyte cells. Inhibitory activity of the extract and compounds on the production of Triglyceride (TG), Cholesterol (CHOL), Glucose-6-Phosphate Dehydrogenase (G6PDH) activity, and lipid droplets were examined. MPE and its compound were capable to inhibit the production of TG, CHOL, G6PDH, lipid droplets. MPE 50 μg/mL and GM 75 μM were the most active to lower TG 57.95% and 59.72%, CHOL 33.33% and 31.68%, G6PDH 52.90%, 41.95%, lipid droplets 72.99% and 70.07% respectively. In conclusion mangosteen peel extract and γ-Mangostin are the most active antiobesity compared to α-Mangostin.

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Published

2018-09-10

How to Cite

Widowati, W., Darsono, L., Suherman, J., Afifah, E., Rizal, R., Arinta, Y., Qodariah, R. L., Mozef, T., & Suciati, T. (2018). Mangosteen Peel Extract (<I>Garcinia mangostana</I> L.) and its Constituents to Lower Lipid Content on Adipogenesis Cells Model (3T3-L1). Journal of Natural Remedies, 18(2), 41–48. https://doi.org/10.18311/jnr/2018/18654

Issue

Volume 18, Issue 2, April 2018

Section

Articles
Crossref
Scopus
Google Scholar
Europe PMC
Received 2017-12-22
Accepted 2018-05-14
Published 2018-09-10

 

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