Development and Evaluation of a Polyherbal Tablet for Polycystic Ovarian Syndrome (PCOS)

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Authors

  • Disha Prajapati
     Parul Institute of Pharmacy and Research, Parul University, Vadodara - 391110, Gujarat ,IN
  • Madhavi Patel
     Parul Institute of Pharmacy, Parul University, Vadodara - 391110, Gujarat ,IN
  • Abhay Dharamsi
     Parul Institute of Pharmacy, Parul University, Vadodara - 391110, Gujarat ,IN

DOI:

https://doi.org/10.18311/jnr/2022/28557

Keywords:

Micromeritics, Polyherbal Formulation, Polycystic Ovarian Syndrome, Physicochemical Evaluation
Pharmacognosy

Abstract

The main objective of the present study was to develop and evaluate polyherbal tablet for the treatment of Polycystic Ovarian Syndrome (PCOS). For the formulation of tablet, the herbs were selected based on the concepts of pathophysiology and Ayurvedic perspective of the disease. The extracts of T. foenum graceum, C. longa, B. aristata, S. asoka, B. variegata and Guggul purified in cow’s urine was used for the preparation of polyherbal tablet. The physicochemical, phytochemical evaluation and quantification of markers by HPTLC of crude drugs and extracts were performed. The guggul was used as binder in different proportion for the preparation of tablet. Pre-formulation study of the powder blend and post compression evaluation of tablet was done by various parameters like weight variation, friability, hardness, thickness, diameter, disintegration time, in-vitro dissolution and accelerated stability study. The physicochemical evaluations of crude drugs yielded results which were in accordance with the monograph’s standard values. The phytochemical analysis of the extracts revealed the presence of variety of phytoconstituents. From the results of HPTLC quantification the amount of curcumin (7.14%) in C. longa, diosgenin (40.6%) in T. foenum graceum ,T. foenum graceum, berberine hydrochloride (4.83%) in B. aristata, catechin (3.48%) in S. asoka, lupeol (0.11%) in B. variegata and Z-guggulsterone (0.140%) and E-guggulsterone (0.146%) in purified guggul was found. The micrometrics of the powder blend of all the formulations showed good flow properties. Formulation F3 showed better results compared to other formulations in post compression evaluation. Accelerated stability study showed that the formulation F3 was stable during the course of study.

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Published

2022-04-19

How to Cite

Prajapati, D., Patel, M., & Dharamsi, A. (2022). Development and Evaluation of a Polyherbal Tablet for Polycystic Ovarian Syndrome (PCOS). Journal of Natural Remedies, 22(2), 161–174. https://doi.org/10.18311/jnr/2022/28557

Issue

Volume 22, Issue 2, April 2022

Section

Research Articles
Crossref
Scopus
Google Scholar
Europe PMC
Received 2021-09-03
Accepted 2021-10-19
Published 2022-04-19

 

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