Herbal Solutions for Urinary Tract Infections: A Literature Review

Jump To References Section

Authors

  • Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara – 391760, Gujarat ,IN
  • Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara – 391760, Gujarat ,IN
  • Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara – 391760, Gujarat ,IN
  • Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara – 391760, Gujarat ,IN

DOI:

https://doi.org/10.18311/jnr/2024/36059

Keywords:

Antimicrobial, Herbal Remedies, Hydration, Probiotics

Abstract

If treatment is not received, Urinary Tract Infections (UTIs), which are frequent microbial illnesses affecting the urinary system, can lead to discomfort and problems. Because they have antibacterial qualities and can potentially reduce UTI symptoms, natural treatments have been used. Supplements or juice made from cranberries are one popular natural treatment. Proanthocyanidins, which are found in cranberries, have the potential to inhibit bacteria, especially E. coli, from adhering to the lining of the urinary tract, hence decreasing the risk of infection. Its efficacy is still up for discussion, though, and certain drinks’ high sugar content may make UTI symptoms worse. D-mannose, a kind of sugar included in fruits like peaches and cranberries, is another commonly utilised treatment. D-mannose inhibits germs from sticking to the walls of the urinary system, in a manner akin to that of cranberries. It’s believed to be effective against E. coli, a common UTI-causing bacterium, but it’s ideal dosage and long-term effects require further research. Probiotics are thought to be helpful for UTIs, particularly those that contain lactobacilli strains. They may lessen the chance of infection by assisting in the maintenance of a balanced population of bacteria in the urinary tract and gut. There is, however, little data to support their direct influence on UTI treatment. Herbal treatments with possible antibacterial effects, such as buchu, goldenseal, and bearberry (uva-ursi), have been used historically. These herbs have ingredients that may aid in the battle against germs in the urinary system, but further research is needed to determine how safe and effective they are. Increasing water consumption is a simple yet effective treatment. Drinking enough water dilutes urine, which lowers the quantity of bacteria that could lead to an illness, and aids in the removal of bacteria from the urinary system. Even while these natural treatments seem promising for treating UTIs, it is important to see a doctor before using them, particularly if you think the illness may be serious. Certain medical issues may prevent the use of natural therapies, or they may interact negatively with medicines. When used as the only treatment for acute UTIs, they are frequently less successful than when used as preventative measures or in conjunction with traditional medicines. The main line of treatment for severe or persistent UTIs is still medical intervention with antibiotics to avoid complications and recurrent infections.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Downloads

Published

2024-03-01

How to Cite

Shah, N., Kumari, M., Sadhu, P., & Talele, C. (2024). Herbal Solutions for Urinary Tract Infections: A Literature Review. Journal of Natural Remedies, 24(3), 537–544. https://doi.org/10.18311/jnr/2024/36059

Issue

Section

Short Review

Categories

Received 2024-01-02
Accepted 2024-02-27
Published 2024-03-01

 

References

Oyelami OA, Agbakwuru EA, Adeyemi LA, Adedeji GB. The effectiveness of grapefruit (Citrus paradisi) seeds in treating urinary tract infections. The Journal of Alternative and Complementary Medicine. 2005; 11(2):369-71. https://doi.org/10.1089/acm.2005.11.369

Griebling TL. Urologic diseases in America project: Trends in resource use for urinary tract infections in women. Journal of Urology. 2005; 173(4):1281-7. https://doi.org/10.1097/01.ju.0000155596.98780.82

Foxman B. Epidemiology of urinary tract infections: incidence, morbidity, and economic costs. American Journal of Medicine. 2002; 113(1):5-13. https://doi.org/10.1016/S0002-9343(02)01054-9

Schrier RW. Diseases of the kidney and urinary tract. Lippincott Williams and Wilkins; 2007.

Finnell SM, Carroll AE, Downs SM. Diagnosis and management of an initial UTI in febrile infants and young children. Pediatrics. 2011; 128(3):e749-70. https://doi.org/10.1542/peds.2011-1332

Barnett BJ, Stephens DS. Urinary tract infection: An overview. American Journal of the Medical Sciences. 1997; 314(4):245-9. https://doi.org/10.1016/S0002-9629(15)40208-3

Nicolle L. Best pharmacological practice: Urinary tract infections. Expert Opinion on Pharmacotherapy. 2003; 4(5):693-704. https://doi.org/10.1517/14656566.4.5.693

Nicolle LE. Uncomplicated urinary tract infection in adults including uncomplicated pyelonephritis. Urologic Clinics of North America. 2008; 35(1):1-2. https://doi.org/10.1016/j.ucl.2007.09.004

Lane DR, Takhar SS. Diagnosis and management of urinary tract infection and pyelonephritis. Emergency Medicine Clinics. 2011; 29(3):539-52. https://doi.org/10.1016/j.emc.2011.04.001

Salvatore S, Salvatore S, Cattoni E, Siesto G, Serati M, Sorice P, et al. Urinary tract infections in women. European Journal of Obstetrics and Gynecology and Reproductive Biology. 2011; 156(2):131-6. https://doi.org/10.1016/j.ejogrb.2011.01.028

Soulsby EJ. Resistance to antimicrobials in humans and animals. Bmj. 2005; 331(7527):1219-20. https://doi.org/10.1136/bmj.331.7527.1219

Neu HC. The crisis in antibiotic resistance. Science. 1992; 257(5073):1064-73. https://doi.org/10.1126/science.257.5073.1064

Geneva WH. Traditional medicine-growing needs and potential. WHO Policy Perspectives Med. 2002; 2:1-6.

Cowan MM. Plant products as antimicrobial agents. Clinical Microbiology Reviews. 1999; 12(4):564-82. https://doi.org/10.1128/CMR.12.4.564

Basile A, Sorbo S, Giordano S, Ricciardi L, Ferrara S, Montesano D, et al. Antibacterial and allelophatic activity of Castanea sativa Mill. leaves. Fitoterapia. 2000; 71:110-6. https://doi.org/10.1016/S0367-326X(00)00185-4

Liu YZ, Cao YG, Ye JQ, Wang WG, Song KJ, Wang XL, et al. Immunomodulatory effects of proanthocyanidin A-1 derived in vitro from Rhododendron spiciferum. Fitoterapia. 2010; 81(2):108-14. https://doi.org/10.1016/j.fitote.2009.08.005

Singh I, Gautam LK, Kaur IR. Effect of oral cranberry extract (standardized proanthocyanidin-A) in patients with recurrent UTI by pathogenic E. coli: A randomized placebo-controlled clinical research study. International Urology and Nephrology. 2016; 48:1379-86. https://doi.org/10.1007/s11255-016-1342-8

Bag A, Bhattacharyya S, Chattopadhyay R. Medicinal plants and urinary tract infections: An update. Pharmacognosy Reviews. 2008; 2(4):277-84.

Newall CA, Anderson LA, Phillipson JD. Herbal medicines. A guide for health-care professionals. The Pharmaceutical Press; 1996.

Bazzaz BSF, Fork SD, Ahmadi R, Khameneh B. Deep insights into urinary tract infections and effective natural remedies. African Journal of Urology. 2021; 27(1):1-3. https://doi.org/10.1186/s12301-020-00111-z

Pedersen M. Nutritional herbology. Bountiful (UT): Pedersen Publishing; 1987.

Blumenthal M. The complete German commission E monographs. Therapeutic guide to herbal medicines; 1999.

Kienholz M, Kemkes B. The antibacterial action of ethereal oils from horseradish root (Cochlearia armoracia L.). Arzneimittel-Forschung. 1960; 10:917-18.

Mody L, Juthani-Mehta M. Urinary tract infections in older women: a clinical review. Jama. 2014; 311(8):844-54. https://doi.org/10.1001/jama.2014.303

Wang H, Luo K, Tan LZ, Ren BG, Gu LQ, Michalopoulos G, et al. p53-induced gene 3 mediates cell death induced by glutathione peroxidase 3. Journal of Alternative and Complementary. 2012; 287(20):16890-902. https://doi.org/10.1074/jbc.M111.322636

Mansour A, Hariri E, Shelh S, Irani R, Mroueh M. Efficient and cost-effective alternative treatment for recurrent urinary tract infections and interstitial cystitis in women: A two-case report. Case reports in Medicine. 2014. https://doi.org/10.1155/2014/698758

Singh A, Purohit B. Tooth brushing, oil pulling and tissue regeneration: A review of holistic approaches to oral health. Journal of Ayurveda and Integrative Medicine. 2011; 2(2):64-8. https://doi.org/10.4103/0975-9476.82525

Chaieb K, Hajlaoui H, Zmantar T, Kahla‐Nakbi AB, Rouabhia M, Mahdouani K, et al. The chemical composition and biological activity of clove essential oil, Eugenia caryophyllata (Syzigium aromaticum L. Myrtaceae): A short review. Journal of Pharmacology and Experimental Therapeutics. 2007; 21(6):501-6. https://doi.org/10.1002/ptr.2124

Bukovská A, Cikoš Š, Juhás Š, Il’ková G, Rehák P, Koppel J. Effects of a combination of thyme and oregano essential oils on TNBS-induced colitis in mice. Mediators of inflammation. 20070; 2007. https://doi.org/10.1155/2007/23296

Blumenthal M, Goldberg A, Brinckmann J. Herbal medicine. Expanded commission E monographs. Integrative Medicine Communications. 2000.

Weiss RF. Herbal Medicine. Gothenburg, Sweden: AB Arcanum. WHO Scientific Group (1967). Principles for pre-clinical testing of drugs safety. Technical Report Series, World Health Organization, Geneva, Switzerland. 1988; 341:9-11.

Weiss RF. Herbal medicine. Gothenburg, Sweden: AB Arcanum. WHO Scientific Group (1967). Principles for Pre-clinical Testing of Drugs Safety. Technical Report Series, World Health Organization, Geneva, Switzerland. 1988; 341:28-34.

Foster S. Tyler’s honest herbal: A sensible guide to the use of herbs and related remedies. Routledge; 1999.

Tyler VE. Herbs of choice: The therapeutic use of phytomedicinals. Pharmaceutical Products Press (imprint of Haworth Press, Inc.); 1994.

Howell AB, Vorsa N, Marderosian AD, Foo LY. Inhibition of the adherence of P-fimbriated Escherichia coli to uroepithelial-cell surfaces by proanthocyanidin extracts from cranberries. New England Journal of Medicine. 1998; 339(15):1085-6. https://doi.org/10.1056/NEJM199810083391516

Krishnaiah D, Devi T, Bono A, Sarbatly R. Studies on phytochemical constituents of six Malaysian medicinal plants. Journal of Medicinal Plants Research. 2009; 3(2):67-72.

Bayne CE, Farah D, Herbst KW, Hsieh MH. Role of urinary tract infection in bladder cancer: a systematic review and meta-analysis. World Journal of Urology. 2018; 36:1181-90. https://doi.org/10.1007/s00345-018-2257-z

Joshi B, Lekhak S, Sharma A. Antibacterial property of different medicinal plants: Ocimum sanctum, Cinnamomum zeylanicum, Xanthoxylum armatum and Origanum majorana. Kathmandu University Journal of Science, Engineering and Technology. 2009.

Shanmugapriya R, Ushadevi T. In vitro antibacterial and antioxidant activities of Apium graveolens L. seed extracts. International Journal of Drug Development. 2014; 6(3):165-70.

Tyler VE. Herbs of choice: The therapeutic use of phytomedicinals. Pharmaceutical Products Press (imprint of Haworth Press, Inc.); 1994.

Bisset NG, Wichtl M. Herbal drugs and phytopharmaceuticals: A handbook for practice on a scientific basis. Medpharm; 1994.

Al-Jiffri O, El-Sayed Z, Al-Sharif FM. Urinary tract infection with Esherichia coli and antibacterial activity of some plants extracts. International Journal of Microbiology. 2011; 2(1):1-7.

Karuppiah P, Rajaram S. Antibacterial effect of Allium sativum cloves and Zingiber officinale rhizomes against multiple-drug resistant clinical pathogens. Asian Pacific Journal of Tropical Biomedicine. 2012; 2(8):597-601. https://doi.org/10.1016/S2221-1691(12)60104-X