Exploring Stevia: A Natural Sweetener with Multifaceted Health Benefits

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Authors

  • Piyushkumar Sadhu
     Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara - 391760, Gujarat ,IN
  • Falguni Rathod
     Sumandeep Nursing College, Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara-391760, Gujarat ,IN
  • Mamta Kumari
     Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara - 391760, Gujarat ,IN
  • Niyati Shah
     Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara - 391760, Gujarat ,IN
  • Chitrali Talele
     Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara - 391760, Gujarat ,IN
  • Chintan Aundhia
     Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara - 391760, Gujarat ,IN

DOI:

https://doi.org/10.18311/jnr/2024/36196

Keywords:

Anti-diabetic, Artificial Sweeteners, Natural Sweeteners, Stevia, Zero Glycemic Index

Abstract

Natural sweeteners, especially those derived from plants, have become popular as low-calorie options compared to traditional sweeteners. Such discussion explores the world of natural sweeteners, emphasizing the growing demand for alternatives to artificial ones like saccharin and cyclamates. These sweeteners, sourced from plants, fruits, and honey, provide a healthier choice with fewer calories. Stevia, extracted from the Stevia rebaudiana plant, is a notable natural sweetener due to its zero-calorie content and strong sweetness. The review explores the background of Stevia, its glycoside compounds, and how it attains its sweetness. The pharmacological aspects of Stevia are also explored, highlighting its potential benefits in managing Type 2 diabetes, reducing blood pressure, alleviating inflammation, acting as an antioxidant, and showing anticancer properties. Studies suggested that Stevia’s active ingredients, are primarily Stevioside and Rebaudioside A, contribute to its sweetness. The chemical composition of these active ingredients is influenced by factors like geographical location, cultivars, and processing methods. Stevia offers advantages such as low caloric content, suitability for diabetics, and benefits for dental health, making it an appealing sugar substitute for those focused on weight management and a health-conscious lifestyle. However, it is important to note potential drawbacks, including a bitter aftertaste, individual sensitivities, and regulatory considerations. Some commercial Stevia products may contain additives that impact their nutritional profile. Despite these factors, high-purity Stevia extracts have received safety approvals from global food safety authorities. In summary, Stevia emerges as a natural sweetener with the potential to address health-related concerns linked to traditional sugar consumption.

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Published

2024-04-01

How to Cite

Sadhu, P., Rathod, F., Kumari, M., Shah, N., Talele, C., & Aundhia, C. (2024). Exploring Stevia: A Natural Sweetener with Multifaceted Health Benefits. Journal of Natural Remedies, 24(4), 757–764. https://doi.org/10.18311/jnr/2024/36196

Issue

Volume 24, Issue 4, April 2024

Section

Short Review

License

Copyright (c) 2024 Piyushkumar Sadhu, Falguni Rathod, Mamta Kumari, Niyati Shah, Chitrali Talele, Chintan Aundhia (Author)

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

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Europe PMC
Received 2024-01-12
Accepted 2024-02-27
Published 2024-04-01

 

References

Ali A, More TA, Shaikh Z. Artificial sweeteners and their health implications: A review. Biosci Biotechnol Res Asia. 2021 A; 18(2):227-37. https://doi.org/10.13005/bbra/2910

Sudan P, Kaur R, Sharma S, Jain U K. A critical review on natural and artificial sweeteners. Pharm Chem J. 2016; 3(1):21-29.

Sharangi AB, Bhutia PH. Stevia: Medicinal miracles and therapeutic magic. Int J Crop Sci Technol. 2016; 2(2).

Carakostas MC, Curry LL, Boileau AC, Brusick DJ. Overview: The history, technical function and safety of Rebaudioside A, a naturally occurring Steviol glycoside, for use in food and beverages. Food Chem Toxicol. 2008; 46(7):S1-0. https://doi.org/10.1016/j.fct.2008.05.003 PMid:18555576

Mejia E, Pearlman M. Natural alternative sweeteners and diabetes management. Curr Diabetes Rep. 2019; 19:1-0. https://doi.org/10.1007/s11892-019-1273-8 PMid:31754814

Singh DP, Kumari M, Prakash HG, Rao GP, Solomon S. Phytochemical and pharmacological importance of Stevia: A calorie free natural sweetener. Rassa J of Sci For Soc. 2020; 2(3):169-76. https://doi.org/10.1007/s12355-019-00704-1

Mayank, Jaitak V. Interaction model of Steviol glycosides from Stevia rebaudiana (Bertoni) with sweet taste receptors: A computational approach. Phytochem. 2015; 116:12-20. https://doi.org/10.1016/j.phytochem.2015.05.006 PMid:26021732

Khiraoui A, Bakha M, Amchra F, Ourouadi S, Boulli A, Al-Faiz C, Hasib A. Nutritional and biochemical properties of natural sweeteners of six cultivars of Stevia rebaudiana Bertoni leaves grown in Morocco. J Mater Environ Sci. 2017; 8(3):1015-22.

Gasmalla MA, Yang R, Amadou I, Hua X. Nutritional composition of Stevia rebaudiana Bertoni leaf: Effect of drying method. Trop J Pharm Res. 2014; 13(1):61-5. https://doi.org/10.4314/tjpr.v13i1.9

Kobus-Moryson M, Grazma-Michałowska A, Kobus-Cisowska J, Korczak J. Zawartośćwybranychpierwiastków w ekstraktachstewii (Stevia rebaudiana Bertoni). Probl Hig Epidemiol. 2014; 95(2):445-8.

Abudula R, Jeppesen PB, Rolfsen SE, Xiao J, Hermansen K. Rebaudioside A potently stimulates insulin secretion from isolated mouse islets: Studies on the dose-, glucose-, and calcium-dependency. Metabolism. 2004; 53(10):1378-81. https://doi.org/10.1016/j.metabol.2004.04.014 PMid:15375798

Chen TH, Chen SC, Chan P, Chu YL, Yang HY, Cheng JT. Mechanism of the hypoglycemic effect of Stevioside, a glycoside of Stevia rebaudiana. Planta Medica. 2005; 71(02):108-13. https://doi.org/10.1055/s-2005-837775 PMid:15729617

Anton SD, Martin CK, Han H, Coulon S, Cefalu WT, Geiselman P, Williamson DA. Effects of Stevia, aspartame, and sucrose on food intake, satiety, and postprandial glucose and insulin levels. Appetite. 2010; 55(1):37-43. https://doi.org/10.1016/j.appet.2010.03.009 PMid:20303371 PMCid:PMC2900484

Chan P, Tomlinson B, Chen YJ, Liu JC, Hsieh MH, Cheng JT. A double‐blind placebo‐controlled study of the effectiveness and tolerability of oral Stevioside in human hypertension. Br J Clin Pharmacol. 2000; 50(3):215-20. https://doi.org/10.1046/j.1365-2125.2000.00260.x PMid:10971305 PMCid:PMC2014988

Lee CN, Wong KL, Liu JC, Chen YJ, Cheng JT, Chan P. Inhibitory effect of Stevioside on calcium influx to produce antihypertension. Planta Medica. 2001; 67(09):796-9. https://doi.org/10.1055/s-2001-18841 PMid:11745013

Boonkaewwan C, Toskulkao C, Vongsakul M. Anti-inflammatory and immunomodulatory activities of Stevioside and its metabolite Steviol on THP-1 cells. J Agric Food Chem. 2006; 54(3):785-9. https://doi. org/10.1021/jf0523465 PMid:16448183

Mizushina Y, Akihisa T, Ukiya M, Hamasaki Y, Murakami-Nakai C, Kuriyama I, Takeuchi T, Sugawara F, Yoshida H. Structural analysis of isoSteviol and related compounds as DNA polymerase and DNA topoisomerase inhibitors. Life Sci. 2005; 77(17):2127-40. https://doi.org/10.1016/j.lfs.2005.03.022 PMid:15935396

Sánchez-Aceves LM, Dublán-García O, López-Martínez LX, Novoa-Luna KA, Islas-Flores H, Galar-Martínez M, García-Medina S, Hernández-Navarro MD, Gómez-Oliván LM. Reduction of the oxidative stress status using Steviol glycosides in a fish model (Cyprinus carpio). BioMed Res Int. 2017; 2017. https://doi.org/10.1155/2017/2352594 PMid:28691017 PMCid:PMC5485310

Rotimi SO, Rotimi OA, Adelani IB, Onuzulu C, Obi P, Okungbaye R. Stevioside modulates oxidative damage in the liver and kidney of high fat/low streptozocin diabetic rats. Heliyon. 2018; 4(5). https://doi.org/10.1016/j.heliyon.2018.e00640 PMid:29872771 PMCid:PMC5986550

Shiozaki K, Fujii A, Nakano T, Yamaguchi T, Sato M. Inhibitory effects of hot water extract of the Stevia stem on the contractile response of the smooth muscle of the guinea pig ileum. Biosci Biotechnol Biochem. 2006; 70(2):489-94. https://doi.org/10.1271/bbb.70.489 PMid:16495667

Takahashi K, Matsuda M, Ohashi K, Taniguchi K, Nakagomi O, Abe Y, Mori S, Sato N, Okutani K, Shigeta S. Analysis of anti-rotavirus activity of extract from Stevia rebaudiana. Antivir Res. 2001; 49(1):15-24. https://doi.org/10.1016/S0166-3542(00)00134-0 PMid:11166857

Chranioti C, Chanioti S, Tzia C. Comparison of spray, freeze and oven drying as a means of reducing bitter aftertaste of Steviol glycosides (derived from Stevia rebaudiana Bertoni plant)–Evaluation of the final products. Food Chem. 2016; 190:1151-8. https://doi.org/10.1016/j.foodchem.2015.06.083 PMid:26213089

Boonkaewwan C, Burodom A. Anti-inflammatory and immunomodulatory activities of Stevioside and Steviol on colonic epithelial cells. J Sci Food Agric. 2013; 93(15):3820-5. https://doi.org/10.1002/jsfa.6287 PMid:23794454

Chen J, Xia Y, Sui X, Peng Q, Zhang T, Li J, Zhang J. Steviol, a natural product inhibits proliferation of the gastrointestinal cancer cells intensively. Oncotarget. 2018; 9(41):26299. https://doi.org/10.18632/oncotarget.25233 PMid:29899860 PMCid:PMC5995179

Mathur S, Bulchandani N, Parihar S, Shekhawat GS. Critical review on Steviol glycosides: Pharmacological, toxicological and therapeutic aspects of high potency zero caloric sweetener. Int J Pharmacol. 2017; 13(7):916-28. https://doi.org/10.3923/ijp.2017.916.928

Tirapelli CR, Ambrosio SR, de Oliveira AM, Tostes RC. Hypotensive action of naturally occurring diterpenes: A therapeutic promise for the treatment of hypertension. Fitoterapia. 2010; 81(7):690-702. https://doi.org/10.1016/j.fitote.2010.05.018 PMid:20685303

de Slavutzky SM. Stevia and sucrose effect on plaque formation. J Verbrauch Lebensm. 2010; 5:213-6. https://doi.org/10.1007/s00003-010-0555-5

Purohit V, Mishra S. The truth about artificial sweeteners–Are they good for diabetics? Indian Heart J. 2018; 70(1):197-9. https://doi.org/10.1016/j.ihj.2018.01.020 PMid:29455781 PMCid:PMC5903011

Curry LL, Roberts A. Subchronic toxicity of Rebaudioside A. Food Chem Toxicol. 2008; 46(7):S11-20. https://doi.org/10.1016/j.fct.2008.04.042 PMid:18562069

Anton SD, Martin CK, Han H, Coulon S, Cefalu WT, Geiselman P, Williamson DA. Effects of Stevia, aspartame, and sucrose on food intake, satiety, and postprandial glucose and insulin levels. Appetite. 2010; 55(1):37-43. https://doi.org/10.1016/j.appet.2010.03.009 PMid:20303371 PMCid:PMC2900484

Prakash I, DuBois GE, Clos JF, Wilkens KL, Fosdick LE. Development of rebiana, a natural, non-caloric sweetener. Food Chem Toxicol. 2008; 46(7):S75-82. https://doi.org/10.1016/j.fct.2008.05.004 PMid:18554769

Konoshima T, Takasaki M. Cancer-chemopreventive effects of natural sweeteners and related compounds. Pure Appl Chem. 2002; 74(7):1309-16. https://doi.org/10.1351/pac200274071309

Wang M, Li H, Xu F, Gao X, Li J, Xu S, Zhang D, Wu X, Xu J, Hua H, Li D. Diterpenoid lead Stevioside and its hydrolysis products Steviol and isoSteviol: Biological activity and structural modification. Eur J Med Chem. 2018; 156:885-906. https://doi.org/10.1016/j.ejmech.2018.07.052 PMid:30059803

Urban JD, Carakostas MC, Taylor SL. Steviol glycoside safety: Are highly purified Steviol glycoside sweeteners food allergens? Food Chem Toxicol. 2015; 75:71-8. https://doi.org/10.1016/j.fct.2014.11.011 PMid:25449199

Silva FV, Bergamasco R, Andrade CM, Pinheiro N, Machado NR, Reis MH, de Araújo ÁA, Rezende SL. Purification process of Stevioside using zeolites and membranes. Int J Chem React Eng. 2007; 5(1). https://doi.org/10.2202/1542-6580.1443

Uçar A, Yılmaz S, Yılmaz Ş, Kılıç MS. A research on the genotoxicity of Stevia in human lymphocytes. Drug Chem Toxicol. 2018; 41(2):221-4. https://doi.org/10.1080/01480545.2017.1349135 PMid:28738695

Mayasari NR, Susetyowati, Wahyuningsih MS, Probosuseno. Antidiabetic effect of rosella-Stevia tea on prediabetic women in Yogyakarta, Indonesia. J Am Coll Nutr. 2018; 37(5):373-9. https://doi.org/10.1080/07315724.2017.1400927 PMid:29425471