Modulation of Oxidative Stress Mediators in Adjuvant Induced Arthritis by Herbal Adaptogen Boswellia serrata
Authors
-
,IN
R. Divisha -
,INM. Usha Rani
-
,INB. Kala Kumar
-
,INA. Gopala Reddy
DOI:
https://doi.org/10.18311/ti/2018/v25i4/23085Keywords:
Adjuvant Arthritis, Antioxidants, Boswellia serrata, Oxidative StressAbstract
A study was carried out to evaluate Boswellia serrata on adjuvant induced oxidative stress in rats. Intradermal administration of Freund's adjuvant to induce rheumatoid arthritis consequently produced oxidative damage as indicated by an increase in thiobarbituric acid reducing substances, myeloperoxidase, protein carbonyls and a reduction in superoxide dismutase, catalase, glutathione peroxidase and reduced glutathione in tissue homogenates. Oral administration of methanolic extracts ofBoswellia serrata at 500 mg/kg body weight re-established the antioxidant profile. Co-treatment with an anti-inflammatory agent, meloxicam showed an enhanced healing effect. Hence, a significant restorative effect was witnessed with the herbal adaptogen Boswellia serrata.
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Accepted 2019-03-28
Published 2019-10-22
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