Toxicological Investigation of Single Oral Dose Administration of Imidacloprid in Male Wistar Rats

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Authors

  • M. K. Lonare
     ,IN
  • Manoj Kumar
     ,IN
  • A. More
     ,IN
  • A. G. Telang
     ,IN

DOI:

https://doi.org/10.18311/ti/2019/v26i1&2/22966

Keywords:

Analgesic Activity, Imidacloprid, Motor Activity, Sleeping Time
Animal Science

Abstract

The aim of this study was to evaluate the acute toxic effect of Imidacloprid (IM) on adult wistar rats. Rats were divided into four different groups. Animals from Group I and II were received water and corn oil, respectively, while, Group III and IV were received oral dose of IM @ 150mg/kg and 300mg/kg body weight, respectively. Thereafter, animals were subjected to series of neuro-toxicity related parameters (general behavioral changes, motor activity, pentobarbitone induced sleeping time and measurement of pain response through mechanical stimulation, radiant heat and tail clip method). IM administration in rats produced significant behavioral depression which resulted into decrease in alertness, awareness and grip strength, and there was reduction in the response to sound, touch and pinna reflexes as compared control. Further, IM resulted in significant decrease in spontaneous locomotor activity and forced locomotor activity (rota-rod performance). IM administration significantly increased the pentobarbitone-induced sleeping time without altering the onset of sleeping time. Orally administered IM did not produce any significant analgesic or hyperalgesic effect. The present study suggests that IM has pronounced CNS effect without effecting analgesic activity during acute toxicosis in animals.

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Published

2020-01-29

How to Cite

Lonare, M. K., Kumar, M., More, A., & Telang, A. G. (2020). Toxicological Investigation of Single Oral Dose Administration of Imidacloprid in Male Wistar Rats. Toxicology International, 26(1&2), 8–14. https://doi.org/10.18311/ti/2019/v26i1&2/22966

Issue

Volume 26, Issue 1&2, January-June 2019

Section

Articles
Crossref
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Europe PMC
Received 2018-12-10
Accepted 2018-12-13
Published 2020-01-29

 

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